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Research Article

Co-assembly of FeTPP@Fe3O4 nanoparticles with photo-enhanced catalytic activity for synergistic tumor therapy

Tian Tian1,§, Jianshuai Bao1,§, Jinghan Wang1, Jiefei Wang2, Yan Ge1, Zengyin Li1, Shanqing Gao1, Zhongqi You1, Xiaoyan Yang1, Yong Zhong1( ), Feng Bai1 ( )
Key Laboratory for Special Functional Materials of Ministry of Education, National & Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology, School of Materials Science and Engineering, Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng 475004, China
Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng 475004, China

§ Tian Tian and Jianshuai Bao contributed equally to this work.

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Graphical Abstract

Iron(III) tetraphenylporphyrin (FeTPP) and magnetic (Fe3O4) composite nanoparticles (FeTPP@Fe3O4 NPs) possess magnetic resonance imaging (MRI) functions were prepared through a one-step microemulsion-assisted co-assembly method. The introduction of Fe3O4 nanocrystals (NCs) enhances disorganized the amorphous aggregation of FeTPP monomers, then increases the aggregation-caused quenching (ACQ) of porphyrins, which endowed FeTPP@Fe3O4 NPs high photothermal performance and photo-enhanced the Fenton reaction for amplified chemodynamic therapy (CDT).

Abstract

Chemodynamic therapy (CDT) offers a promising alternative to conventional cancer treatment. However, the limited acidity and H2O2 concentration in tumor microenvironment (TME) severely impair the anticancer effects of CDT. In this study, we report a microemulsion-assisted coassembly method to prepare iron(III) tetraphenylporphyrin (FeTPP) and magnetic (Fe3O4) nanocomposite material (FeTPP@Fe3O4), using photoactive FeTPP and Fe3O4 nanocrystals as building blocks. The self-assembling nature of FeTPP results in disordered aggregation and fluorescence quenching, leading to a high light-to-heat conversion efficiency. Continuously, the photo-thermal effect enhances the catalytic decomposition of hydrogen peroxide (H2O2) in the Fenton reaction on Fe3O4 nanocrystals to generate highly toxic hydroxyl radicals (·OH) to destroy cancer cells. This cascade reaction produces a synergistic therapeutic effect between CDT and photothermal therapy (PTT), which significantly amplifies the therapeutic effect and enhances the treatment outcome of cancer patients. The highly efficient tumor catalytic therapy in vivo results confirmed that this nanomedicine treatment is an excellent biocompatible catalytic nanomedicine therapy achieved through a photo-enhanced Fenton reaction activity approach.

Keywords

porphyrinphoto-enhancednanocatalystsynergistic therapy

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Nano Research
Volume 15 Issue 10,
October 2022
Pages 9114-9124
DOI: 10.1007/s12274-022-4548-3
Cite this article:
Tian T, Bao J, Wang J, et al. Co-assembly of FeTPP@Fe3O4 nanoparticles with photo-enhanced catalytic activity for synergistic tumor therapy. Nano Research, 2022, 15(10): 9114-9124. https://doi.org/10.1007/s12274-022-4548-3
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Received: 26 March 2022
Revised: 16 May 2022
Accepted: 16 May 2022
Published: 23 July 2022
© Tsinghua University Press 2022
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