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Chemodynamic therapy (CDT) offers a promising alternative to conventional cancer treatment. However, the limited acidity and H2O2 concentration in tumor microenvironment (TME) severely impair the anticancer effects of CDT. In this study, we report a microemulsion-assisted coassembly method to prepare iron(III) tetraphenylporphyrin (FeTPP) and magnetic (Fe3O4) nanocomposite material (FeTPP@Fe3O4), using photoactive FeTPP and Fe3O4 nanocrystals as building blocks. The self-assembling nature of FeTPP results in disordered aggregation and fluorescence quenching, leading to a high light-to-heat conversion efficiency. Continuously, the photo-thermal effect enhances the catalytic decomposition of hydrogen peroxide (H2O2) in the Fenton reaction on Fe3O4 nanocrystals to generate highly toxic hydroxyl radicals (·OH) to destroy cancer cells. This cascade reaction produces a synergistic therapeutic effect between CDT and photothermal therapy (PTT), which significantly amplifies the therapeutic effect and enhances the treatment outcome of cancer patients. The highly efficient tumor catalytic therapy in vivo results confirmed that this nanomedicine treatment is an excellent biocompatible catalytic nanomedicine therapy achieved through a photo-enhanced Fenton reaction activity approach.

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Publication history

Received: 26 March 2022
Revised: 16 May 2022
Accepted: 16 May 2022
Published: 23 July 2022
Issue date: October 2022

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© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 21802032, U21A2085, and 52102345), China Postdoctoral Science Foundation (No. 2019TQ0081), Zhongyuan High Level Talents Special Support Plan (No. 204200510009), and Scientific and Technological Innovation Team in University of Henan Province (No. 20IRTSTHN001).

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Reprints and Permission requests may be sought directly from editorial office.
Email: nanores@tup.tsinghua.edu.cn

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