Journal Home > Volume 15 , Issue 10

The use of antibiotic could cause severe drug-resistance and the increasing spread of pathogenic drug-resistant bacteria has brought a big threat to human health, hence, some innovative methods inspired, such as sonodynamic therapy, have become increasingly attractive for realizing the antibiotic-free methods against bacterial infection. However, many pathogens can invade normal healthy cells to establish intracellular replicative niches, which makes it more difficult to kill and remove these bacteria. Herein, inspired by respiratory mucus trapping bacteria to kill them, we developed a novel gel of amorphous TiOx nanofibers dotted with Ti2C(OH)2 nanosheets, which could capture and trap bacteria into the gel via a strong binding ability toward bacteria by forming a Ti–O–P bond between phosphate in the bacterial wall and Ti-OH in the gel, thereby, efficiently blocking the invasions of bacteria. Also, the gel has excellent ability for generating reactive oxygen species (ROS) under ultrasound irradiation, therefore, the bacteria in the gel could be effectively killed by the ROS produced under ultrasound irradiation. Moreover, Ti2C(OH)2 in the gel was able to scavenge H2O2, and transfer it into O2 in the infection environment, providing enough O2 for sonodynamic therapy. The experimental results have demonstrated that the functional gel obviously accelerated the healing of multidrug-resistant microorganisms-infected wounds.

File
12274_2022_4547_MOESM1_ESM.pdf (697.5 KB)
Publication history
Copyright
Acknowledgements

Publication history

Received: 18 March 2022
Revised: 10 May 2022
Accepted: 16 May 2022
Published: 18 July 2022
Issue date: October 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was financially supported by the National Key Research and Development Program of China (No. 2020YFA0710700), the National Natural Science Funds for Distinguished Young Scholars (No. 51625305), the National Natural Science Foundation of China (Nos. 52131305, 52073269, 51873202, 22131010, 22101275, 81603339, 81602344, and 31870993), and the Fundamental Research Funds for the Central Universities (Nos. YD2060002016 and WK9110000005).

Return