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Nano Research 2022, 15(10): 8783-8790 https://doi.org/10.1007/s12274-022-4541-x
Research Article | Issue | Published: 15 June 2022

Ultrathin covalent organic framework nanosheet-based photoregulated metal-free oxidase-like nanozyme

Show Author's Information Yongwu Peng1,4,  Minchu Huang1,  Liangjun Chen1,  Chengtao Gong1,  Nanjun Li1,  Ying Huang2( ),  Changming Cheng3( )
College of Materials Science and Engineering and College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
State Key Laboratory of Environment-friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010, China
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics (CAEP), Mianyang 612900, China
Jiangsu Province Engineering Research Center of Agricultural Breeding Pollution Control and Resource, Yancheng Teachers University, Yancheng 224007, China
Keywords:
ultrathin, oxidase mimics, metal-free, covalent organic framework nanosheets, photoregulated
Topics:
Catalysis
Cite this article:
Peng Y, Huang M, Chen L, et al. Ultrathin covalent organic framework nanosheet-based photoregulated metal-free oxidase-like nanozyme. Nano Research, 2022, 15(10): 8783-8790. https://doi.org/10.1007/s12274-022-4541-x
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Abstract Full text Electronic supplementary material About this article

The exploration of low-cost and metal-free nanozymes with oxidase-mimicking activity is highly desired due to their attractive properties and potential applications. However, it is still challenging and remains unexploited to fully realize oxidase-like nanozyme in the emerging covalent organic frameworks (COFs) due to their polymeric nature and weak photoelectric activity. We herein report the first example of the preparation and oxidase-mimicking activity of novel ultrathin two-dimensional (2D) COF (termed as TTPA-COF) nanosheets. The ultrathin TTPA-COF nanosheets with hexagonal layered structure are constructed from two flexible photoactive (diarylamino)benzene-based linkers, and exhibit remarkable catalytic activity toward the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of O2 due to their large specific surface areas and abundant active sites. Moreover, it is worth noting that the nanozyme activity could be regulated by external light irradiation. Based on the oxidase-mimicking activity of TTPA-COF nanosheets, a green colorimetric sensor is proposed for the sensitive and selective determination of glutathione (GSH) in a wide linear range of 0.5–40 µM with a detection limit of 0.5 µM. This work reported here would open new avenues for the exploration of low-cost and high-efficiency nanozymes, as well as extend the application of 2D COF nanosheets in the fields of catalysis and sensing.


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About this article

Ultrathin covalent organic framework nanosheet-based photoregulated metal-free oxidase-like nanozyme

Show Author's information Yongwu Peng1,4, Minchu Huang1, Liangjun Chen1, Chengtao Gong1, Nanjun Li1, Ying Huang2( ), Changming Cheng3( )
College of Materials Science and Engineering and College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
State Key Laboratory of Environment-friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010, China
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics (CAEP), Mianyang 612900, China
Jiangsu Province Engineering Research Center of Agricultural Breeding Pollution Control and Resource, Yancheng Teachers University, Yancheng 224007, China

Abstract

The exploration of low-cost and metal-free nanozymes with oxidase-mimicking activity is highly desired due to their attractive properties and potential applications. However, it is still challenging and remains unexploited to fully realize oxidase-like nanozyme in the emerging covalent organic frameworks (COFs) due to their polymeric nature and weak photoelectric activity. We herein report the first example of the preparation and oxidase-mimicking activity of novel ultrathin two-dimensional (2D) COF (termed as TTPA-COF) nanosheets. The ultrathin TTPA-COF nanosheets with hexagonal layered structure are constructed from two flexible photoactive (diarylamino)benzene-based linkers, and exhibit remarkable catalytic activity toward the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of O2 due to their large specific surface areas and abundant active sites. Moreover, it is worth noting that the nanozyme activity could be regulated by external light irradiation. Based on the oxidase-mimicking activity of TTPA-COF nanosheets, a green colorimetric sensor is proposed for the sensitive and selective determination of glutathione (GSH) in a wide linear range of 0.5–40 µM with a detection limit of 0.5 µM. This work reported here would open new avenues for the exploration of low-cost and high-efficiency nanozymes, as well as extend the application of 2D COF nanosheets in the fields of catalysis and sensing.

Keywords: ultrathin, oxidase mimics, metal-free, covalent organic framework nanosheets, photoregulated

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Publication history
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Acknowledgements

Publication history

Received: 11 February 2022
Revised: 05 April 2022
Accepted: 16 May 2022
Published: 15 June 2022
Issue date: October 2022

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© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the financial support from the National Natural Science Foundation of China (NSFC) (Nos. 21976166, 22006122, and 21405144), the research funding of “Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang” (No. 2020R01002) and the Class D of Qianjiang Talent Program (No. ZD20011250001), the Science Challenge Project (No. TZ2016004), the Project of State Key Laboratory of Environment-friendly Energy Materials (No. 18zd320303), and the Scientific Research Starting Foundation for Returned Overseas Chinese Scholars of Sichuan Province (No. 19zd3200). Y. W. P. thanks the financial support from the Opening Project of Jiangsu Province Engineering Research Center of Agricultural Breeding Pollution Control and Resource (No. 2021ABPCR004).

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