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Nano Research 2022, 15(9): 8336-8344 https://doi.org/10.1007/s12274-022-4508-y
Research Article | Issue | Published: 08 July 2022

Rapidly separable bubble microneedle patch for effective local anesthesia

Show Author's Information Yuan Yang1,2,§,  Huaqing Chu3,§,  Yan Zhang4,§,  Lingling Xu5,  Ruizeng Luo1,  Hui Zheng3( ),  Tailang Yin6( ),  Zhou Li1,2,7,8( )
CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, Guangxi University, Nanning 530004, China
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

§ Yuan Yang, Huaqing Chu, and Yan Zhang contributed equally to this work.

Keywords:
hyaluronic acid, separable bubble microneedle patch, rapid drug delivery, local anesthesia, cutaneous cosmetology surgery
Topics:
Biological systems
Cite this article:
Yang Y, Chu H, Zhang Y, et al. Rapidly separable bubble microneedle patch for effective local anesthesia. Nano Research, 2022, 15(9): 8336-8344. https://doi.org/10.1007/s12274-022-4508-y
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Abstract Full text About this article

In cutaneous cosmetology surgery, local injection or coated anesthetics are generally used to provide analgesia at the treatment site to achieve painless operation. Due to the barrier of corneum, topical cream may cause uncertain dosage and delayed analgesia. Local injection has problems such as pain, infection, and misoperation. Therefore, it is necessary to develop a painless and rapid administration method for local anesthesia. Here, a lidocaine/hyaluronic acid bubble microneedle patch (Lido/HA bMNP) was prepared for rapid drug delivery and efficient analgesia. The bubble structure between microneedles (MNs) and the backing layer allowed the MNs to efficiently penetrate into the skin and remove from the backing layer under shear force to rapidly complete the administration. Drugs were quickly released with the dissolution of HA within 15 s, which immediately played an analgesic effect and lasted for 1 h. Lido/HA bMNP could deliver precise doses to the skin in an extremely short time, which had the advantages of convenient operation, high biosafety, rapid onset of analgesia, and reasonable pain relief time. This patch provided an alternative way for local anesthesia and it was a promising transdermal drug delivery method for the realization of high quality and efficiency “painless medical beauty”.


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About this article

Rapidly separable bubble microneedle patch for effective local anesthesia

Show Author's information Yuan Yang1,2,§, Huaqing Chu3,§, Yan Zhang4,§, Lingling Xu5, Ruizeng Luo1, Hui Zheng3( ), Tailang Yin6( ), Zhou Li1,2,7,8( )
CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, Guangxi University, Nanning 530004, China
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

§ Yuan Yang, Huaqing Chu, and Yan Zhang contributed equally to this work.

Abstract

In cutaneous cosmetology surgery, local injection or coated anesthetics are generally used to provide analgesia at the treatment site to achieve painless operation. Due to the barrier of corneum, topical cream may cause uncertain dosage and delayed analgesia. Local injection has problems such as pain, infection, and misoperation. Therefore, it is necessary to develop a painless and rapid administration method for local anesthesia. Here, a lidocaine/hyaluronic acid bubble microneedle patch (Lido/HA bMNP) was prepared for rapid drug delivery and efficient analgesia. The bubble structure between microneedles (MNs) and the backing layer allowed the MNs to efficiently penetrate into the skin and remove from the backing layer under shear force to rapidly complete the administration. Drugs were quickly released with the dissolution of HA within 15 s, which immediately played an analgesic effect and lasted for 1 h. Lido/HA bMNP could deliver precise doses to the skin in an extremely short time, which had the advantages of convenient operation, high biosafety, rapid onset of analgesia, and reasonable pain relief time. This patch provided an alternative way for local anesthesia and it was a promising transdermal drug delivery method for the realization of high quality and efficiency “painless medical beauty”.

Keywords: hyaluronic acid, separable bubble microneedle patch, rapid drug delivery, local anesthesia, cutaneous cosmetology surgery

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Publication history
Copyright
Acknowledgements

Publication history

Received: 15 April 2022
Revised: 04 May 2022
Accepted: 06 May 2022
Published: 08 July 2022
Issue date: September 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 61875015 and T2125003), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDA16021101), and Beijing Natural Science Foundation (Nos. JQ20038, L212010, and L212046).

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