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Research Article

Insight on metal ions inducing chiral self-assembly of DNA in silica mineralization

Arepati Azhati1, Lu Han2, Zhibei Qu3( ), Zhouhong Ren4, Xi Liu4 ( ), Liwei Chen4, Shunai Che1,2 ( )
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai 200240, China
School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China
School of Chemical Science and Engineering, In-situ Center for Physical Sciences, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, China
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Abstract

The self-assembly of DNA provides an attractive approach to understanding structural formation mechanism in living organisms and to assisting applications in materials chemistry. Herein, we investigated the effect of metal ions on chiral self-assembly of DNA through the synthesis of chiral mesostructured silica via self-assembly of metal ions, DNA, and silica source. 31 types of multivalent cationic metal ions were found to induce formation of chiral impeller-like DNA-silica complexes due to the chiral stacking of DNA. The strength of the interaction between the metal ion and phosphate group of DNA was speculated for the chiral stacking of DNA due to close distance of adjacent DNA to assure mutual recognition. Theoretical calculations indicated that chiral packing of DNA depends on the stability of the bridging phosphate-metal ion-phosphate bonds of DNA based on electron delocalization in d-orbital conjugation of metal ions.

Graphical Abstract

There are 31 types of multivalent cationic metal ions were found to induce formation of chiral impeller-like DNA-silica complexes in the periodic table due to the chiral stacking of DNA. Based on this directing concept, 31 types of ultra-small metal nanoparticles (UMNPs) were easily confined in chiral mesostructured silica supports leading to widespread applications.

Keywords

chiralityDNADNA-metal ions interactionsilicaultra-small metal-nanoparticle

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Nano Research
Volume 16 Issue 3,
March 2023
Pages 3998-4003
DOI: 10.1007/s12274-022-4460-x

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Cite this article:
Azhati A, Han L, Qu Z, et al. Insight on metal ions inducing chiral self-assembly of DNA in silica mineralization. Nano Research, 2023, 16(3): 3998-4003. https://doi.org/10.1007/s12274-022-4460-x
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Received: 15 March 2022
Revised: 16 April 2022
Accepted: 20 April 2022
Published: 17 June 2022
© Tsinghua University Press 2022