Metformin capped Cu₂(OH)₃Cl nanosheets for chemodynamic wound disinfection

Recently, the development of chemodynamic therapy (CDT) offers a potential approach for fighting bacteria and treating infectious diseases, in which those CDT nanoagents can catalyze the generation of hydroxyl radicals (•OH) to destroy bacteria. In this work, to improve the efficiency of CDT, we have designed a new kind of metformin (Met)-capped two-dimensional Cu₂(OH)₃Cl nanosheets (CuOHCl-Met NSs) with good monodispersity, highly positive charge, and good biocompatibility for improving antibacterial effect and accelerating wound healing. With the capped Met, CuOHCl-Met NSs can effectively kill bacteria under a low concentration (6 μg·mL⁻¹) and a short treatment time (in 15 min), showing great advantages over the counterpart without Met. In vivo results demonstrated that CuOHCl-Met NSs accelerated the tissue regeneration of staphylococcus aureus-infected dermal wounds. This study provides a new pathway for improving efficiency of CDT nanoagent through using old drug.