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Nano Research 2023, 16(2): 2672-2681 https://doi.org/10.1007/s12274-022-4439-7
Research Article | Issue | Published: 24 May 2022

Nanomechanical vibration profiling of oocytes

Show Author's Information Yongpei Peng1,§,  Junhui Zhang2,3,4,§,  Weiwei Xue1,  Wenjie Wu1,  Yu Wang1,  Kainan Mei1,  Ye Chen1,  Depeng Rao1,  Tianhao Yan1,  Jianye Wang1,  Yunxia Cao2,3,4( ),  Shangquan Wu1( ),  Qingchuan Zhang1( )
CAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027, China
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230027, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei 230027, China
Key Laboratory of Population Health Across Life Cycle, Ministry of Education of the People’s Republic of China, Anhui Medical University, Hefei 230027, China

§ Yongpei Peng and Junhui Zhang contributed equally to this work.

Keywords:
metabolism, oocytes, nanomechanical sensors, nanomechaincal vibration, microfilaments
Topics:
Cells
Cite this article:
Peng Y, Zhang J, Xue W, et al. Nanomechanical vibration profiling of oocytes. Nano Research, 2023, 16(2): 2672-2681. https://doi.org/10.1007/s12274-022-4439-7
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Abstract Electronic supplementary material About this article

The beginning of a mammalian life commences with a fertilized oocyte. The study of oocytes is certainly one of the most intriguing scientific questions of our time. Herein, we studied oocytes from a mechanical perspective and characterized the typical life activities of oocytes by nanomechanical vibrations. During the development of oocytes from the germinal vesicle (GV) stage to the zygotes, the GV stage oocytes induced a significant nanomechanical vibration, compared with the oocytes in meiosis I (MI) and meiosis II (MII) stages and zygotes. We analyzed the characteristics of mechanical vibrations of oocytes, including the amplitude as well as the frequency. It showed that the amplitude and frequency of nanomechanical vibrations induced by oocytes were caused by the cytoskeleton (microfilaments) and the distribution of metabolic characteristics (mitochondria) within oocytes. This work provides a new perspective for clinical quality assessment and basic research of oocytes, and can open new doors for development of life science.

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Acknowledgements

Publication history

Received: 16 February 2022
Revised: 14 April 2022
Accepted: 17 April 2022
Published: 24 May 2022
Issue date: February 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

Y. P. P. and J. H. Z. performed research; Y. P. P. analyzed data and wrote the paper; Y. C., S. Q. W., and Q. C. Z. gave constructive guidance; W. W. X., W. J. W., Y. W., K. N. M., Y. C., D. P. R., T. H. Y., and J. Y. W. participated in the design of this article.All authors read and approved the final manuscript. The authors gratefully acknowledge financial support from the National Natural Science Foundation of China (Nos. 11627803, 32061160475, and 11872355).

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