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Nano Research 2022, 15(9): 8156-8184 https://doi.org/10.1007/s12274-022-4430-3
Review Article | Issue | Published: 28 May 2022

Innovations and challenges of polyphenol-based smart drug delivery systems

Show Author's Information Yanan Wang1,§,  Jingwen Zhang1,§,  Yi Zhao2,  Minju Pu1,  Xinyu Song1,  Liangmin Yu1( ),  Xuefeng Yan1,  Jun Wu2( ),  Zhiyu He1( )
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China

§ Yanan Wang and Jingwen Zhang contributed equally to this work.

Keywords:
metal-phenolic network, polymer-phenolic nanoparticles, metal-phenolic coatings, metal-phenolic hollow capsules, polyphenol–protein interactions
Topics:
Drug delivery
Cite this article:
Wang Y, Zhang J, Zhao Y, et al. Innovations and challenges of polyphenol-based smart drug delivery systems. Nano Research, 2022, 15(9): 8156-8184. https://doi.org/10.1007/s12274-022-4430-3
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Abstract Full text About this article

Polyphenols, as widely existing natural bioactive products, provide a vast array of advanced biomedical applications attributing to their potential health benefits that linked to antioxidant, anti-inflammatory, immunoregulatory, neuroprotective, cardioprotective function, etc. The polyphenol compounds could dynamically interact and bind with diverse species (such as polymers, metal ions, biomacromolecules, etc.) via multiple interactions, including hydrogen bond, hydrophobic, π–π, and cation–π interactions due to their unique chemical polyphenolic structures, providing far-ranging strategies for designing of polyphenol-based vehicles. Natural polyphenols emerged as multifaceted players, acting either as inherent therapeutics delivered to combat diverse diseases or as pivotal assemblies of drug delivery vehicles. In this review, we focused on the rational design and application of metal-phenolic network (MPN) based delivery systems, polyphenol-based coating films, polyphenol hollow capsules, polyphenol-incorporated hydrogels, and polymer-polyphenol-based nanoparticles (NPs) in various diseases therapeutic, including cancer, infection, cardiovascular disease, neurodegenerative disease, etc. Additionally. the versatility and mechanisms of polyphenols in the field of biomacromolecules (e.g., protein, peptide, nucleic acid, etc.) delivery and cell therapy have been comprehensively summarized. Going through the literature review, the remaining challenges of polyphenol-containing nanosystems need to be addressed are involved, including long-term stability, biosafety in vivo, feasibility of scale-up, etc., which may enlighten the further developments of this field. This review provides perspectives in utilizing natural polyphenol-based biomaterials to rationally design next generation versatile drug delivery system in the field of biomedicine, which eventually benefits public health.


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About this article

Innovations and challenges of polyphenol-based smart drug delivery systems

Show Author's information Yanan Wang1,§, Jingwen Zhang1,§, Yi Zhao2, Minju Pu1, Xinyu Song1, Liangmin Yu1( ), Xuefeng Yan1, Jun Wu2( ), Zhiyu He1( )
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China

§ Yanan Wang and Jingwen Zhang contributed equally to this work.

Abstract

Polyphenols, as widely existing natural bioactive products, provide a vast array of advanced biomedical applications attributing to their potential health benefits that linked to antioxidant, anti-inflammatory, immunoregulatory, neuroprotective, cardioprotective function, etc. The polyphenol compounds could dynamically interact and bind with diverse species (such as polymers, metal ions, biomacromolecules, etc.) via multiple interactions, including hydrogen bond, hydrophobic, π–π, and cation–π interactions due to their unique chemical polyphenolic structures, providing far-ranging strategies for designing of polyphenol-based vehicles. Natural polyphenols emerged as multifaceted players, acting either as inherent therapeutics delivered to combat diverse diseases or as pivotal assemblies of drug delivery vehicles. In this review, we focused on the rational design and application of metal-phenolic network (MPN) based delivery systems, polyphenol-based coating films, polyphenol hollow capsules, polyphenol-incorporated hydrogels, and polymer-polyphenol-based nanoparticles (NPs) in various diseases therapeutic, including cancer, infection, cardiovascular disease, neurodegenerative disease, etc. Additionally. the versatility and mechanisms of polyphenols in the field of biomacromolecules (e.g., protein, peptide, nucleic acid, etc.) delivery and cell therapy have been comprehensively summarized. Going through the literature review, the remaining challenges of polyphenol-containing nanosystems need to be addressed are involved, including long-term stability, biosafety in vivo, feasibility of scale-up, etc., which may enlighten the further developments of this field. This review provides perspectives in utilizing natural polyphenol-based biomaterials to rationally design next generation versatile drug delivery system in the field of biomedicine, which eventually benefits public health.

Keywords: metal-phenolic network, polymer-phenolic nanoparticles, metal-phenolic coatings, metal-phenolic hollow capsules, polyphenol–protein interactions

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Publication history
Copyright
Acknowledgements

Publication history

Received: 23 March 2022
Revised: 10 April 2022
Accepted: 12 April 2022
Published: 28 May 2022
Issue date: September 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 82003673) and the National Key R&D Program of China (Nos. 2019YFC0312101 and 2019YFC0312102).

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