Seh, Z. W.; Kibsgaard, J.; Dickens, C. F.; Chorkendorff, I.; Nørskov, J. K.; Jaramillo, T. F. Combining theory and experiment in electrocatalysis: Insights into materials design. Science 2017, 355, eaad4998.

Chu, S.; Majumdar, A. Opportunities and challenges for a sustainable energy future. Nature 2012, 488, 294–303.

Zhong, M.; Tran, K.; Min, Y. M.; Wang, C. H.; Wang, Z. Y.; Dinh, C. T.; De Luna, P.; Yu, Z. Q.; Rasouli, A. S.; Brodersen, P. et al. Accelerated discovery of CO₂ electrocatalysts using active machine learning. Nature 2020, 581, 178–183.

García de Arquer, F. P.; Dinh, C. T.; Ozden, A.; Wicks, J.; McCallum, C.; Kirmani, A. R.; Nam, D. H.; Gabardo, C.; Seifitokaldani, A.; Wang, X. et al. CO₂ electrolysis to multicarbon products at activities greater than 1 A·cm⁻². Science 2020, 367, 661–666.

Mistry, H.; Varela, A. S.; Kühl, S.; Strasser, P.; Cuenya, B. R. Nanostructured electrocatalysts with tunable activity and selectivity. Nat. Rev. Mater. 2016, 1, 16009.

Anson, C. W.; Stahl, S. S. Mediated fuel cells: Soluble redox mediators and their applications to electrochemical reduction of O₂ and oxidation of H₂, alcohols, biomass, and complex fuels. Chem. Rev. 2020, 120, 3749–3786.

Shao, M. H.; Chang, Q. W.; Dodelet, J. P.; Chenitz, R. Recent advances in electrocatalysts for oxygen reduction reaction. Chem. Rev. 2016, 116, 3594–3657.

Maurer, F.; Jelic, J.; Wang, J. J.; Gänzler, A.; Dolcet, P.; Wöll, C.; Wang, Y. M.; Studt, F.; Casapu, M.; Grunwaldt, J. D. Tracking the formation, fate and consequence for catalytic activity of Pt single sites on CeO₂. Nat. Catal. 2020, 3, 824–833.

Zhang, J. Q.; Zhao, Y. F.; Guo, X.; Chen, C.; Dong, C. L.; Liu, R. S.; Han, C. P.; Li, Y. D.; Gogotsi, Y.; Wang, G. X. Single platinum atoms immobilized on an MXene as an efficient catalyst for the hydrogen evolution reaction. Nat. Catal. 2018, 1, 985–992.

Xie, X. H.; He, C.; Li, B. Y.; He, Y. H.; Cullen, D. A.; Wegener, E. C.; Kropf, A. J.; Martinez, U.; Cheng, Y. W.; Engelhard, M. H. et al. Performance enhancement and degradation mechanism identification of a single-atom Co-N-C catalyst for proton exchange membrane fuel cells. Nat. Catal. 2020, 3, 1044–1054.

Wang, J.; Kim, S. J.; Liu, J. P.; Gao, Y.; Choi, S.; Han, J.; Shin, H.; Jo, S.; Kim, J.; Ciucci, F. et al. Redirecting dynamic surface restructuring of a layered transition metal oxide catalyst for superior water oxidation. Nat. Catal. 2021, 4, 212–222.

Liu, C.; Qian, J.; Ye, Y. F.; Zhou, H.; Sun, C. J.; Sheehan, C.; Zhang, Z. Y.; Wan, G.; Liu, Y. S.; Guo, J. H. et al. Oxygen evolution reaction over catalytic single-site Co in a well-defined brookite TiO₂ nanorod surface. Nat. Catal. 2021, 4, 36–45.

Adabi, H.; Shakouri, A.; Ul Hassan, N.; Varcoe, J. R.; Zulevi, B.; Serov, A.; Regalbuto, J. R.; Mustain, W. E. High-performing commercial Fe-N-C cathode electrocatalyst for anion-exchange membrane fuel cells. Nat. Energy 2021, 6, 834–843.

Wang, Y.; Zheng, X. B.; Wang, D. S. Design concept for electrocatalysts. Nano Res. 2022, 15, 1730–1752.

Zhang, T. J.; Walsh, A. G.; Yu, J. H.; Zhang, P. Single-atom alloy catalysts: Structural analysis, electronic properties and catalytic activities. Chem. Soc. Rev. 2021, 50, 569–588.

Zhao, D.; Zhuang, Z. W.; Cao, X.; Zhang, C.; Peng, Q.; Chen, C.; Li, Y. D. Atomic site electrocatalysts for water splitting, oxygen reduction and selective oxidation. Chem. Soc. Rev. 2020, 49, 2215–2264.

Zhuo, H. Y.; Zhang, X.; Liang, J. X.; Yu, Q.; Xiao, H.; Li, J. Theoretical understandings of graphene-based metal single-atom catalysts: Stability and catalytic performance. Chem. Rev. 2020, 120, 12315–12341.

Qin, R. X.; Liu, K. L.; Wu, Q. Y.; Zheng, N. F. Surface coordination chemistry of atomically dispersed metal catalysts. Chem. Rev. 2020, 120, 11810–11899.

Wang, Y. X.; Su, H. Y.; He, Y. H.; Li, L. G.; Zhu, S. Q.; Shen, H.; Xie, P. F.; Fu, X. B.; Zhou, G. Y.; Feng, C. et al. Advanced electrocatalysts with single-metal-atom active sites. Chem. Rev. 2020, 120, 12217–12314.

Zhang, L. L.; Zhou, M. X.; Wang, A. Q.; Zhang, T. Selective hydrogenation over supported metal catalysts: From nanoparticles to single atoms. Chem. Rev. 2020, 120, 683–733.

Zhang, J.; Wang, Z. J.; Chen, W. X.; Xiong, Y.; Cheong, W. C.; Zheng, L. R.; Yan, W. S.; Gu, L.; Chen, C.; Peng, Q. et al. Tuning polarity of Cu–O bond in heterogeneous Cu catalyst to promote additive-free hydroboration of alkynes. Chem 2020, 6, 725–737.

Li, W. H.; Yang, J. R.; Wang, D. S.; Li, Y. D. Striding the threshold of an atom era of organic synthesis by single-atom catalysis. Chem 2022, 8, 119–140.

Xu, Q.; Guo, C. X.; Li, B. B.; Zhang, Z. D.; Qiu, Y. J.; Tian, S. B.; Zheng, L. R.; Gu, L.; Yan, W. S.; Wang, D. S. et al. Al³⁺ dopants induced Mg²⁺ vacancies stabilizing single-atom Cu catalyst for efficient free-radical hydrophosphinylation of alkenes. J. Am. Chem. Soc. 2022, 144, 4321–4326.

Chen, S. H.; Li, W. H.; Jiang, W. J.; Yang, J. R.; Zhu, J. X.; Wang, L. Q.; Ou, H. H.; Zhuang, Z. C.; Chen, M. Z.; Sun, X. H. et al. MOF encapsulating N-heterocyclic carbene-ligated copper single-atom site catalyst towards efficient methane electrosynthesis. Angew. Chem., Int. Ed. 2022, 61, e202114450.

Yang, J. R.; Li, W. H.; Tan, S. D.; Xu, K. N.; Wang, Y.; Wang, D. S.; Li, Y. D. The electronic metal–support interaction directing the design of single atomic site catalysts: Achieving high efficiency towards hydrogen evolution. Angew. Chem., Int. Ed. 2021, 60, 19085–19091.

Xiong, Y.; Sun, W. M.; Han, Y. H.; Xin, P. Y.; Zheng, X. S.; Yan, W. S.; Dong, J. C.; Zhang, J.; Wang, D. S.; Li, Y. D. Cobalt single atom site catalysts with ultrahigh metal loading for enhanced aerobic oxidation of ethylbenzene. Nano Res. 2021, 14, 2418–2423.

Zhang, Z. D.; Zhou, M.; Chen, Y. J.; Liu, S. J.; Wang, H. F.; Zhang, J.; Ji, S. F.; Wang, D. S.; Li, Y. D. Pd single-atom monolithic catalyst: Functional 3D structure and unique chemical selectivity in hydrogenation reaction. Sci. China Mater. 2021, 64, 1919–1929.

Yang, J. R.; Li, W. H.; Wang, D. S.; Li, Y. D. Electronic metal–support interaction of single-atom catalysts and applications in electrocatalysis. Adv. Mater. 2020, 32, 2003300.

Zhang, J.; Zheng, C. Y.; Zhang, M. L.; Qiu, Y. J.; Xu, Q.; Cheong, W. C.; Chen, W. X.; Zheng, L. R.; Gu, L.; Hu, Z. P. et al. Controlling N-doping type in carbon to boost single-atom site Cu catalyzed transfer hydrogenation of quinoline. Nano Res. 2020, 13, 3082–3087.

Liu, Y. W.; Wu, X.; Li, Z.; Zhang, J.; Liu, S. X.; Liu, S. J.; Gu, L.; Zheng, L. R.; Li, J.; Wang, D. S. et al. Fabricating polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration. Nat. Commun. 2021, 12, 4205.

Jing, H. Y.; Liu, W.; Zhao, Z. Y.; Zhang, J. W.; Zhu, C.; Shi, Y. T.; Wang, D. S.; Li, Y. D. Electronics and coordination engineering of atomic cobalt trapped by oxygen-driven defects for efficient cathode in solar cells. Nano Energy 2021, 89, 106365.

Li, W. H.; Yang, J. R.; Jing, H. Y.; Zhang, J.; Wang, Y.; Li, J.; Zhao, J.; Wang, D. S.; Li, Y. D. Creating high regioselectivity by electronic metal–support interaction of a single-atomic-site catalyst. J. Am. Chem. Soc. 2021, 143, 15453–15461.

Zhao, C. M.; Dai, X. Y.; Yao, T.; Chen, W. X.; Wang, X. Q.; Wang, J.; Yang, J.; Wei, S. Q.; Wu, Y. E.; Li, Y. D. Ionic Exchange of metal-organic frameworks to access single nickel sites for efficient electroreduction of CO₂. J. Am. Chem. Soc. 2017, 139, 8078–8081.

Zhang, L. Z.; Fischer, J. M. T. A.; Jia, Y.; Yan, X. C.; Xu, W.; Wang, X. Y.; Chen, J.; Yang, D. J.; Liu, H. W.; Zhuang, L. Z. et al. Coordination of atomic Co–Pt coupling species at carbon defects as active sites for oxygen reduction reaction. J. Am. Chem. Soc. 2018, 140, 10757–10763.

Wang, J.; Huang, Z. Q.; Liu, W.; Chang, C. R.; Tang, H. L.; Li, Z. J.; Chen, W. X.; Jia, C. J.; Yao, T.; Wei, S. Q. et al. Design of N-coordinated dual-metal sites: A stable and active Pt-free catalyst for acidic oxygen reduction reaction. J. Am. Chem. Soc. 2017, 139, 17281–17284.

Wan, J. W.; Zhao, Z. H.; Shang, H. S.; Peng, B.; Chen, W. X.; Pei, J. J.; Zheng, L. R.; Dong, J. C.; Cao, R.; Sarangi, R. et al. In situ phosphatizing of triphenylphosphine encapsulated within metal-organic frameworks to design atomic Co₁–P₁N₃ interfacial structure for promoting catalytic performance. J. Am. Chem. Soc. 2020, 142, 8431–8439.

Jiang, W. J.; Gu, L.; Li, L.; Zhang, Y.; Zhang, X.; Zhang, L. J.; Wang, J. Q.; Hu, J. S.; Wei, Z. D.; Wan, L. J. Understanding the high activity of Fe-N-C electrocatalysts in oxygen reduction: Fe/Fe₃C nanoparticles boost the activity of Fe-N_x. J. Am. Chem. Soc. 2016, 138, 3570–3578.

Zhang, E. H.; Tao, L.; An, J. K.; Zhang, J. W.; Meng, L. Z.; Zheng, X. B.; Wang, Y.; Li, N.; Du, S. X.; Zhang, J. T. et al. Engineering the local atomic environments of indium single-atom catalysts for efficient electrochemical production of hydrogen peroxide. Angew. Chem., Int. Ed. 2022, 61, e202117347.

Yang, J. R.; Li, W. H.; Xu, K. N.; Tan, S. D.; Wang, D. S.; Li, Y. D. Regulating the tip effect on single-atom and cluster catalysts: Forming reversible oxygen species with high efficiency in chlorine evolution reaction. Angew. Chem., Int. Ed. 2022, 134, e202200366.

Wang, Y.; Zheng, M.; Li, Y. R.; Ye, C. L.; Chen, J.; Ye, J. Y.; Zhang, Q. H.; Li, J.; Zhou, Z. Y.; Fu, X. Z. et al. p-d orbital hybridization induced by a monodispersed Ga site on a Pt₃Mn nanocatalyst boosts ethanol electrooxidation. Angew. Chem., Int. Ed. 2022, 61, e202115735.

Zhao, Q.; Sun, J.; Li, S. C.; Huang, C. P.; Yao, W. F.; Chen, W.; Zeng, T.; Wu, Q.; Xu, Q. J. Single nickel atoms anchored on nitrogen-doped graphene as a highly active cocatalyst for photocatalytic H₂ evolution. ACS Catal. 2018, 8, 11863–11874.

Shi, R.; Tian, C. C.; Zhu, X.; Peng, C. Y.; Mei, B. B.; He, L.; Du, X. L.; Jiang, Z.; Chen, Y.; Dai, S. Achieving an exceptionally high loading of isolated cobalt single atoms on a porous carbon matrix for efficient visible-light-driven photocatalytic hydrogen production. Chem. Sci. 2019, 10, 2585–2591.

Liang, Z. B.; Qu, C.; Xia, D. G.; Zou, R. Q.; Xu, Q. Atomically dispersed metal sites in MOF-based materials for electrocatalytic and photocatalytic energy conversion. Angew. Chem., Int. Ed. 2018, 57, 9604–9633.

Ji, S. F.; Qu, Y.; Wang, T.; Chen, Y. J.; Wang, G. F.; Li, X.; Dong, J. C.; Chen, Q. Y.; Zhang, W. Y.; Zhang, Z. D. et al. Rare-earth single erbium atoms for enhanced photocatalytic CO₂ reduction. Angew. Chem., Int. Ed. 2020, 59, 10651–10657.

Wang, G.; He, C. T.; Huang, R.; Mao, J. J.; Wang, D. S.; Li, Y. D. Photoinduction of Cu single atoms decorated on UiO-66-NH₂ for enhanced photocatalytic reduction of CO₂ to liquid fuels. J. Am. Chem. Soc. 2020, 142, 19339–19345.

Lu, C.; Fang, R. Y.; Chen, X. Single-atom catalytic materials for advanced battery systems. Adv. Mater. 2020, 32, 1906548.

Zhuang, Z. C.; Kang, Q.; Wang, D. S.; Li, Y. D. Single-atom catalysis enables long-life, high-energy lithium-sulfur batteries. Nano Res. 2020, 13, 1856–1866.

Lai, W. H.; Wang, H.; Zheng, L. R.; Jiang, Q.; Yan, Z. C.; Wang, L.; Yoshikawa, H.; Matsumura, D.; Sun, Q.; Wang, Y. X. et al. General synthesis of single-atom catalysts for hydrogen evolution reactions and room-temperature Na-S batteries. Angew. Chem., Int. Ed. 2020, 59, 22171–22178.

Zhang, B. W.; Sheng, T.; Liu, Y. D.; Wang, Y. X.; Zhang, L.; Lai, W. H.; Wang, L.; Yang, J. P.; Gu, Q. F.; Chou, S. L. et al. Atomic cobalt as an efficient electrocatalyst in sulfur cathodes for superior room-temperature sodium-sulfur batteries. Nat. Commun. 2018, 9, 4082.

Cui, T. T.; Wang, Y. P.; Ye, T.; Wu, J.; Chen, Z. Q.; Li, J.; Lei, Y. P.; Wang, D. S.; Li, Y. D. Engineering dual single-atom sites on 2D ultrathin N-doped carbon nanosheets attaining ultra-low-temperature zinc-air battery. Angew. Chem., Int. Ed. 2022, 61, e202115219.

Jiao, L.; Yan, H. Y.; Wu, Y.; Gu, W. L.; Zhu, C. Z.; Du, D.; Lin, Y. H. When nanozymes meet single-atom catalysis. Angew. Chem., Int. Ed. 2020, 59, 2565–2576.

Xiang, H. J.; Feng, W.; Chen, Y. Single-atom catalysts in catalytic biomedicine. Adv. Mater. 2020, 32, 1905994.

Ji, S.; Jiang, B.; Hao, H.; Chen, Y.; Dong, J.; Mao, Y.; Zhang, Z.; Gao, R.; Chen, W.; Zhang, R. et al. Matching the kinetics of natural enzymes with a single-atom iron nanozyme. Nat. Catal. 2021, 4, 407–417.

Zhang, N. Q.; Ye, C. L.; Yan, H.; Li, L. C.; He, H.; Wang, D. S.; Li, Y. D. Single-atom site catalysts for environmental catalysis. Nano Res. 2020, 13, 3165–3182.

Shang, Y. N.; Xu, X.; Gao, B. Y.; Wang, S. B.; Duan, X. G. Single-atom catalysis in advanced oxidation processes for environmental remediation. Chem. Soc. Rev. 2021, 50, 5281–5322.

Wan, J. W.; Chen, W. X.; Jia, C. Y.; Zheng, L. R.; Dong, J. C.; Zheng, X. S.; Wang, Y.; Yan, W. S.; Chen, C.; Peng, Q. et al. Defect effects on TiO₂ nanosheets: Stabilizing single atomic site Au and promoting catalytic properties. Adv. Mater. 2018, 30, 1705369.

Zhang, J.; Huang, Q. A.; Wang, J.; Wang, J.; Zhang, J. J.; Zhao, Y. F. Supported dual-atom catalysts: Preparation, characterization, and potential applications. Chin. J. Catal. 2020, 41, 783–798.

Zhang, W. Y.; Chao, Y. G.; Zhang, W. S.; Zhou, J. H.; Lv, F.; Wang, K.; Lin, F. X.; Luo, H.; Li, J.; Tong, M. P. et al. Emerging dual-atomic-site catalysts for efficient energy catalysis. Adv. Mater. 2021, 33, 2102576.

Pan, Y.; Zhang, C.; Liu, Z.; Chen, C.; Li, Y. D. Structural regulation with atomic-level precision: From single-atomic site to diatomic and atomic interface catalysis. Matter 2020, 2, 78–110.

Rong, H. P.; Ji, S. F.; Zhang, J. T.; Wang, D. D.; Li, Y. D. Synthetic strategies of supported atomic clusters for heterogeneous catalysis. Nat. Commun. 2020, 11, 5884.

Wang, J.; You, R.; Zhao, C.; Zhang, W.; Liu, W.; Fu, X. P.; Li, Y. Y.; Zhou, F. Y.; Zheng, X. S.; Xu, Q. et al. N-coordinated dual-metal single-site catalyst for low-temperature CO oxidation. ACS Catal. 2020, 10, 2754–2761.

Chen, J. Y.; Li, H.; Fan, C.; Meng, Q. W.; Tang, Y. W.; Qiu, X. Y.; Fu, G. T.; Ma, T. Y. Dual single-atomic Ni-N₄ and Fe-N₄ sites constructing janus hollow graphene for selective oxygen electrocatalysis. Adv. Mater. 2020, 32, 2003134.

Han, X. P.; Ling, X. F.; Yu, D. S.; Xie, D. Y.; Li, L. L.; Peng, S. J.; Zhong, C.; Zhao, N. Q.; Deng, Y. D.; Hu, W. B. Atomically dispersed binary Co-Ni sites in nitrogen-doped hollow carbon nanocubes for reversible oxygen reduction and evolution. Adv. Mater. 2019, 31, 1905622.

Lin, L.; Li, H. B.; Yan, C. C.; Li, H. F.; Si, R.; Li, M. R.; Xiao, J. P.; Wang, G. X.; Bao, X. H. Synergistic catalysis over iron-nitrogen sites anchored with cobalt phthalocyanine for efficient CO₂ electroreduction. Adv. Mater. 2019, 31, 1903470.

Zhou, Y.; Song, E. H.; Chen, W.; Segre, C. U.; Zhou, J. D.; Lin, Y. C.; Zhu, C.; Ma, R. G.; Liu, P.; Chu, S. F. et al. Dual-metal interbonding as the chemical facilitator for single-atom dispersions. Adv. Mater. 2020, 32, 2003484.

Tian, S. B.; Fu, Q.; Chen, W. X.; Feng, Q. C.; Chen, Z.; Zhang, J.; Cheong, W. C.; Yu, R.; Gu, L.; Dong, J. C. et al. Carbon nitride supported Fe₂ cluster catalysts with superior performance for alkene epoxidation. Nat. Commun. 2018, 9, 2353.

Li, H. L.; Wang, L. B.; Dai, Y. Z.; Pu, Z. T.; Lao, Z. H.; Chen, Y. W.; Wang, M. L.; Zheng, X. S.; Zhu, J. F.; Zhang, W. H. et al. Synergetic interaction between neighbouring platinum monomers in CO₂ hydrogenation. Nat. Nanotechnol. 2018, 13, 411–417.

Yang, Y.; Qian, Y. M.; Li, H. J.; Zhang, Z. H.; Mu, Y. W.; Do, D.; Zhou, B.; Dong, J.; Yan, W. J.; Qin, Y. et al. O-coordinated W-Mo dual-atom catalyst for pH-universal electrocatalytic hydrogen evolution. Sci. Adv. 2020, 6, eaba6586.

Hou, C. C.; Wang, H. F.; Li, C. X.; Xu, Q. From metal-organic frameworks to single/dual-atom and cluster metal catalysts for energy applications. Energy Environ. Sci. 2020, 13, 1658–1693.

Qi, K.; Chhowalla, M.; Voiry, D. Single atom is not alone: Metal–support interactions in single-atom catalysis. Mater. Today 2020, 40, 173–192.

Fang, X. Z.; Jiao, L.; Yu, S. H.; Jiang, H. L. Metal-organic framework-derived FeCo-N-doped hollow porous carbon nanocubes for electrocatalysis in acidic and alkaline media. ChemSusChem 2017, 10, 3019–3024.

Ji, S. F.; Chen, Y. J.; Fu, Q.; Chen, Y. F.; Dong, J. C.; Chen, W. X.; Li, Z.; Wang, Y.; Gu, L.; He, W. et al. Confined pyrolysis within metal-organic frameworks to form uniform Ru₃ clusters for efficient oxidation of alcohols. J. Am. Chem. Soc. 2017, 139, 9795–9798.

Zhu, Z. J.; Yin, H. J.; Wang, Y.; Chuang, C. H.; Xing, L.; Dong, M. Y.; Lu, Y. R.; Casillas-Garcia, G.; Zheng, Y. L.; Chen, S. et al. Coexisting single-atomic Fe and Ni sites on hierarchically ordered porous carbon as a highly efficient ORR electrocatalyst. Adv. Mater. 2020, 32, 2004670.

Ji, S. F.; Chen, Y. J.; Wang, X. L.; Zhang, Z. D.; Wang, D. S.; Li, Y. D. Chemical synthesis of single atomic site catalysts. Chem. Rev. 2020, 120, 11900–11955.

Xiong, Y.; Dong, J. C.; Huang, Z. Q.; Xin, P. Y.; Chen, W. X.; Wang, Y.; Li, Z.; Jin, Z.; Xing, W.; Zhuang, Z. B. et al. Single-atom Rh/N-doped carbon electrocatalyst for formic acid oxidation. Nat. Nanotechnol. 2020, 15, 390–397.

Li, Z.; Chen, Y. J.; Ji, S. F.; Tang, Y.; Chen, W. X.; Li, A.; Zhao, J.; Xiong, Y.; Wu, Y. E.; Gong, Y. et al. Iridium single-atom catalyst on nitrogen-doped carbon for formic acid oxidation synthesized using a general host–guest strategy. Nat. Chem. 2020, 12, 764–772.

Wang, J.; Liu, W.; Luo, G.; Li, Z. J.; Zhao, C.; Zhang, H. R.; Zhu, M. Z.; Xu, Q.; Wang, X. Q.; Zhao, C. M. et al. Synergistic effect of well-defined dual sites boosting the oxygen reduction reaction. Energy Environ. Sci. 2018, 11, 3375–3379.

Wei, Y. S.; Sun, L. M.; Wang, M.; Hong, J. H.; Zou, L. L.; Liu, H. W.; Wang, Y.; Zhang, M.; Liu, Z.; Li, Y. W. et al. Fabricating dual-atom iron catalysts for efficient oxygen evolution reaction: A heteroatom modulator approach. Angew. Chem., Int. Ed. 2020, 59, 16013–16022.

Qiao, B. T.; Wang, A. Q.; Yang, X. F.; Allard, L. F.; Jiang, Z.; Cui, Y. T.; Liu, J. Y.; Li, J.; Zhang, T. Single-atom catalysis of CO oxidation using Pt1/FeO_x. Nat. Chem. 2011, 3, 634–641.

Lu, J. L.; Elam, J. W.; Stair, P. C. Synthesis and stabilization of supported metal catalysts by atomic layer deposition. Acc. Chem. Res. 2013, 46, 1806–1815.

Lu, J. L. A perspective on new opportunities in atom-by-atom synthesis of heterogeneous catalysts using atomic layer deposition. Catal. Lett. 2021, 151, 1535–1545.

Zhang, L.; Banis, M. N.; Sun, X. L. Single-atom catalysts by the atomic layer deposition technique. Natl. Sci. Rev. 2018, 5, 628–630.

Cheng, N. C.; Stambula, S.; Wang, D.; Banis, M. N.; Liu, J.; Riese, A.; Xiao, B. W.; Li, R. Y.; Sham, T. K.; Liu, L. M. et al. Platinum single-atom and cluster catalysis of the hydrogen evolution reaction. Nat. Commun. 2016, 7, 13638.

Sun, S. H.; Zhang, G. X.; Gauquelin, N.; Chen, N.; Zhou, J. G.; Yang, S. L.; Chen, W. F.; Meng, X. B.; Geng, D. S.; Banis, M. N. et al. Single-atom catalysis using Pt/graphene achieved through atomic layer deposition. Sci. Rep. 2013, 3, 1775.

Cao, Y. J.; Chen, S.; Luo, Q. Q.; Yan, H.; Lin, Y.; Liu, W.; Cao, L. L.; Lu, J. L.; Yang, J. L.; Yao, T. et al. Atomic-level insight into optimizing the hydrogen evolution pathway over a Co₁-N₄ single-site photocatalyst. Angew. Chem., Int. Ed. 2017, 56, 12191–12196.

Yan, H.; Lin, Y.; Wu, H.; Zhang, W. H.; Sun, Z. H.; Cheng, H.; Liu, W.; Wang, C. L.; Li, J. J.; Huang, X. H. et al. Bottom-up precise synthesis of stable platinum dimers on graphene. Nat. Commun. 2017, 8, 1070.

Zhang, L.; Si, R. T.; Liu, H. S.; Chen, N.; Wang, Q.; Adair, K.; Wang, Z. Q.; Chen, J. T.; Song, Z. X.; Li, J. J. et al. Atomic layer deposited Pt-Ru dual-metal dimers and identifying their active sites for hydrogen evolution reaction. Nat. Commun. 2019, 10, 4936.

Zhang, Z. R.; Feng, C.; Liu, C. X.; Zuo, M.; Qin, L.; Yan, X. P.; Xing, Y. L.; Li, H. L.; Si, R.; Zhou, S. M. et al. Electrochemical deposition as a universal route for fabricating single-atom catalysts. Nat. Commun. 2020, 11, 1215.

Shi, Y.; Huang, W. M.; Li, J.; Zhou, Y.; Li, Z. Q.; Yin, Y. C.; Xia, X. H. Site-specific electrodeposition enables self-terminating growth of atomically dispersed metal catalysts. Nat. Commun. 2020, 11, 4558.

Shi, Y.; Ma, Z. R.; Xiao, Y. Y.; Yin, Y. C.; Huang, W. M.; Huang, Z. C.; Zheng, Y. Z.; Mu, F. Y.; Huang, R.; Shi, G. Y. et al. Electronic metal–support interaction modulates single-atom platinum catalysis for hydrogen evolution reaction. Nat. Commun. 2021, 12, 3021.

Bai, L. C.; Hsu, C. S.; Alexander, D. T. L.; Chen, H. M.; Hu, X. L. A cobalt-iron double-atom catalyst for the oxygen evolution reaction. J. Am. Chem. Soc. 2019, 141, 14190–14199.

Zhao, Y. Y.; Yan, X. X.; Yang, K. R.; Cao, S. F.; Dong, Q.; Thorne, J. E.; Materna, K. L.; Zhu, S. S.; Pan, X. Q.; Flytzani-Stephanopoulos, M. et al. End-on bound iridium dinuclear heterogeneous catalysts on WO₃ for solar water oxidation. ACS Cent. Sci. 2018, 4, 1166–1172.

Zhao, Y. Y.; Yang, K. R.; Wang, Z. C.; Yan, X. X.; Cao, S. F.; Ye, Y. F.; Dong, Q.; Zhang, X. Z.; Thorne, J. E.; Jin, L. et al. Stable iridium dinuclear heterogeneous catalysts supported on metal-oxide substrate for solar water oxidation. Proc. Natl. Acad. Sci. USA 2018, 115, 2902–2907.

Gao, R. J.; Wang, J.; Huang, Z. F.; Zhang, R. R.; Wang, W.; Pan, L.; Zhang, J. F.; Zhu, W. K.; Zhang, X. W.; Shi, C. X. et al. Pt/Fe₂O₃ with Pt-Fe pair sites as a catalyst for oxygen reduction with ultralow Pt loading. Nat. Energy 2021, 6, 614–623.

Vorobyeva, E.; Fako, E.; Chen, Z. P.; Collins, S. M.; Johnstone, D.; Midgley, P. A.; Hauert, R.; Safonova, O. V.; Vilé, G.; López, N. et al. Atom-by-atom resolution of structure-function relations over low-nuclearity metal catalysts. Angew. Chem., Int. Ed. 2019, 58, 8724–8729.

Wang, Y.; Mao, J.; Meng, X. G.; Yu, L.; Deng, D. H.; Bao, X. H. Catalysis with two-dimensional materials confining single atoms: Concept, design, and applications. Chem. Rev. 2019, 119, 1806–1854.

Hannagan, R. T.; Giannakakis, G.; Flytzani-Stephanopoulos, M.; Sykes, E. C. H. Single-atom alloy catalysis. Chem. Rev. 2020, 120, 12044–12088.

He, Z. Y.; He, K.; Robertson, A. W.; Kirkland, A. I.; Kim, D.; Ihm, J.; Yoon, E.; Lee, G. D.; Warner, J. H. Atomic structure and dynamics of metal dopant pairs in graphene. Nano Lett. 2014, 14, 3766–3772.

Gu, J.; Jian, M. Z.; Huang, L.; Sun, Z. H.; Li, A. W.; Pan, Y.; Yang, J. Z.; Wen, W.; Zhou, W.; Lin, Y. et al. Synergizing metal–support interactions and spatial confinement boosts dynamics of atomic nickel for hydrogenations. Nat. Nanotechnol. 2021, 16, 1141–1149.

Timoshenko, J.; Roldan Cuenya, B. In situ/operando electrocatalyst characterization by X-ray absorption spectroscopy. Chem. Rev. 2021, 121, 882–961.

Frati, F.; Hunault, M. O. J. Y.; de Groot, F. M. F. Oxygen K-edge X-ray absorption spectra. Chem. Rev. 2020, 120, 4056–4110.

Zhao, J.; Ji, S. F.; Guo, C. X.; Li, H. J.; Dong, J. C.; Guo, P.; Wang, D. S.; Li, Y. D.; Toste, F. D. A heterogeneous iridium single-atom-site catalyst for highly regioselective carbenoid O–H bond insertion. Nat. Catal. 2021, 4, 523–531.

Fei, H. L.; Dong, J. C.; Chen, D. L.; Hu, T. D.; Duan, X. D.; Shakir, I.; Huang, Y.; Duan, X. F. Single atom electrocatalysts supported on graphene or graphene-like carbons. Chem. Soc. Rev. 2019, 48, 5207–5241.

Xia, Z. M.; Zhang, H.; Shen, K. C.; Qu, Y. Q.; Jiang, Z. Wavelet analysis of extended X-ray absorption fine structure data: Theory, application. Phys. B:Condens. Matter 2018, 542, 12–19.

Tian, S. B.; Wang, B. X.; Gong, W. B.; He, Z. Z.; Xu, Q.; Chen, W. X.; Zhang, Q. H.; Zhu, Y. Q.; Yang, J. R.; Fu, Q. et al. Dual-atom Pt heterogeneous catalyst with excellent catalytic performances for the selective hydrogenation and epoxidation. Nat. Commun. 2021, 12, 3181.

Zhang, N.; Zhou, T. P.; Ge, J. K.; Lin, Y.; Du, Z. Y.; Zhong, C. A.; Wang, W. J.; Jiao, Q. Y.; Yuan, R. L.; Tian, Y. C. et al. High-density planar-like Fe₂N₆ structure catalyzes efficient oxygen reduction. Matter 2020, 3, 509–521.

Xiao, M. L.; Chen, Y. T.; Zhu, J. B.; Zhang, H.; Zhao, X.; Gao, L. Q.; Wang, X.; Zhao, J.; Ge, J. J.; Jiang, Z. et al. Climbing the apex of the ORR volcano plot via binuclear site construction: Electronic and geometric engineering. J. Am. Chem. Soc. 2019, 141, 17763–17770.

Bai, L. C.; Hsu, C. S.; Alexander, D. T. L.; Chen, H. M.; Hu, X. L. Double-atom catalysts as a molecular platform for heterogeneous oxygen evolution electrocatalysis. Nat. Energy 2021, 6, 1054–1066.

Ding, T.; Liu, X. K.; Tao, Z. N.; Liu, T. Y.; Chen, T.; Zhang, W.; Shen, X. Y.; Liu, D.; Wang, S. C.; Pang, B. B. et al. Atomically precise dinuclear site active toward electrocatalytic CO₂ reduction. J. Am. Chem. Soc. 2021, 143, 11317–11324.

Li, Y. W.; Su, H. B.; Chan, S. H.; Sun, Q. CO₂ electroreduction performance of transition metal dimers supported on graphene: A theoretical study. ACS Catal. 2015, 5, 6658–6664.

Shen, H. M.; Li, Y. W.; Sun, Q. CO₂ electroreduction performance of phthalocyanine sheet with Mn dimer:A theoretical study. J. Phys. Chem. C 2017, 121, 3963–3969.

Cui, T. T.; Ma, L. N.; Wang, S. B.; Ye, C. L.; Liang, X.; Zhang, Z. D.; Meng, G.; Zheng, L. R.; Hu, H. S.; Zhang, J. W. et al. Atomically dispersed Pt-N₃C₁ sites enabling efficient and selective electrocatalytic C–C bond cleavage in lignin models under ambient conditions. J. Am. Chem. Soc. 2021, 143, 9429–9439.

Jing, H. Y.; Zhu, P.; Zheng, X. B.; Zhang, Z. D.; Wang, D. S.; Li, Y. D. Theory-oriented screening and discovery of advanced energy transformation materials in electrocatalysis. Adv. Powder Mater. 2022, 1, 100013.

Liang, Z.; Song, L. P.; Sun, M. Z.; Huang, B. L.; Du, Y. P. Tunable CO/H₂ ratios of electrochemical reduction of CO₂ through the Zn-Ln dual atomic catalysts. Sci. Adv. 2021, 7, eabl4915.

Sun, M. Z.; Wong, H. H.; Wu, T.; Dougherty, A. W.; Huang, B. L. Stepping out of transition metals: Activating the dual atomic catalyst through main group elements. Adv. Energy Mater. 2021, 11, 2101404.

Sun, M. Z.; Wong, H. H.; Wu, T.; Dougherty, A. W.; Huang, B. L. Entanglement of spatial and energy segmentation for C₁ pathways in CO₂ reduction on carbon skeleton supported atomic catalysts. Adv. Energy Mater. 2022, 12, 2103781.

Sun, M. Z.; Wu, T.; Dougherty, A. W.; Lam, M.; Huang, B. L.; Li, Y. L.; Yan, C. H. Self-validated machine learning study of graphdiyne-based dual atomic catalyst. Adv. Energy Mater. 2021, 11, 2003796.

Luo, G.; Jing, Y.; Li, Y. F. Rational design of dual-metal-site catalysts for electroreduction of carbon dioxide. J. Mater. Chem. A 2020, 8, 15809–15815.

Yao, Y. C.; Hu, S. L.; Chen, W. X.; Huang, Z. Q.; Wei, W. C.; Yao, T.; Liu, R. R.; Zang, K. T.; Wang, X. Q.; Wu, G. et al. Engineering the electronic structure of single atom Ru sites via compressive strain boosts acidic water oxidation electrocatalysis. Nat. Catal. 2019, 2, 304–313.

Greiner, M. T.; Jones, T. E.; Beeg, S.; Zwiener, L.; Scherzer, M.; Girgsdies, F.; Piccinin, S.; Armbrüster, M.; Knop-Gericke, A.; Schlögl, R. Free-atom-like d states in single-atom alloy catalysts. Nat. Chem. 2018, 10, 1008–1015.

Lee, J.; Kumar, A.; Yang, T.; Liu, X. H.; Jadhav, A. R.; Park, G. H.; Hwang, Y.; Yu, J. M.; Nguyen, C. T. K.; Liu, Y. et al. Stabilizing the OOH* intermediate via pre-adsorbed surface oxygen of a single Ru atom-bimetallic alloy for ultralow overpotential oxygen generation. Energy Environ. Sci. 2020, 13, 5152–5164.

Hwang, J.; Noh, S. H.; Han, B. Design of active bifunctional electrocatalysts using single atom doped transition metal dichalcogenides. Appl. Surf. Sci. 2019, 471, 545–552.

Yang, T.; Song, T. T.; Zhou, J.; Wang, S. J.; Chi, D. Z.; Shen, L.; Yang, M.; Feng, Y. P. High-throughput screening of transition metal single atom catalysts anchored on molybdenum disulfide for nitrogen fixation. Nano Energy 2020, 68, 104304.

Lv, X. S.; Wei, W.; Huang, B. B.; Dai, Y.; Frauenheim, T. High-throughput screening of synergistic transition metal dual-atom catalysts for efficient nitrogen fixation. Nano Lett. 2021, 21, 1871–1878.

Ulissi, Z. W.; Tang, M. T.; Xiao, J. P.; Liu, X. Y.; Torelli, D. A.; Karamad, M.; Cummins, K.; Hahn, C.; Lewis, N. S.; Jaramillo, T. F. et al. Machine-learning methods enable exhaustive searches for active bimetallic facets and reveal active site motifs for CO₂ reduction. ACS Catal. 2017, 7, 6600–6608.

Jinnouchi, R.; Hirata, H.; Asahi, R. Extrapolating energetics on clusters and single-crystal surfaces to nanoparticles by machine-learning scheme. J. Phys. Chem. C 2017, 121, 26397–26405.

Sun, M. Z.; Dougherty, A. W.; Huang, B. L.; Li, Y. L.; Yan, C. H. Accelerating atomic catalyst discovery by theoretical calculations-machine learning strategy. Adv. Energy Mater. 2020, 10, 1903949.

Zhu, X. R.; Yan, J. X.; Gu, M.; Liu, T. Y.; Dai, Y. F.; Gu, Y. H.; Li, Y. F. Activity origin and design principles for oxygen reduction on dual-metal-site catalysts: A combined density functional theory and machine learning study. J. Phys. Chem. Lett. 2019, 10, 7760–7766.

Liu, M. M.; Wang, L. L.; Zhao, K. N.; Shi, S. S.; Shao, Q. S.; Zhang, L.; Sun, X. L.; Zhao, Y. F.; Zhang, J. J. Atomically dispersed metal catalysts for the oxygen reduction reaction: Synthesis, characterization, reaction mechanisms and electrochemical energy applications. Energy Environ. Sci. 2019, 12, 2890–2923.

Zheng, X. B.; Li, P.; Dou, S. X.; Sun, W. P.; Pan, H. G.; Wang, D. S.; Li, Y. D. Non-carbon-supported single-atom site catalysts for electrocatalysis. Energy Environ. Sci. 2021, 14, 2809–2858.

Li, S.; Chen, B. B.; Wang, Y.; Ye, M. Y.; van Aken, P. A.; Cheng, C.; Thomas, A. Oxygen-evolving catalytic atoms on metal carbides. Nat. Mater. 2021, 20, 1240–1247.

Zheng, X. B.; Cui, P. X.; Qian, Y. M.; Zhao, G. Q.; Zheng, X. S.; Xu, X.; Cheng, Z. X.; Liu, Y. Y.; Dou, S. X.; Sun, W. P. Multifunctional active-center-transferable platinum/lithium cobalt oxide heterostructured electrocatalysts towards superior water splitting. Angew. Chem., Int. Ed. 2020, 59, 14533–14540.

Zheng, X. B.; Chen, Y. P.; Zheng, X. S.; Zhao, G. Q.; Rui, K.; Li, P.; Xu, X.; Cheng, Z. X.; Dou, S. X.; Sun, W. P. Electronic structure engineering of LiCoO₂ toward enhanced oxygen electrocatalysis. Adv. Energy Mater. 2019, 9, 1803482.

Jiang, K.; Liu, B. Y.; Luo, M.; Ning, S. C.; Peng, M.; Zhao, Y.; Lu, Y. R.; Chan, T. S.; de Groot, F. M. F.; Tan, Y. W. Single platinum atoms embedded in nanoporous cobalt selenide as electrocatalyst for accelerating hydrogen evolution reaction. Nat. Commun. 2019, 10, 1743.

Wu, J. B.; Xiong, L. K.; Zhao, B. T.; Liu, M. L.; Huang, L. Densely populated single atom catalysts. Small Methods 2020, 4, 1900540.

Zhu, J.; Hu, L. S.; Zhao, P. X.; Lee, L. Y. S.; Wong, K. Y. Recent advances in electrocatalytic hydrogen evolution using nanoparticles. Chem. Rev. 2020, 120, 851–918.

Rui, K.; Zhao, G. Q.; Lao, M. M.; Cui, P. X.; Zheng, X. S.; Zheng, X. B.; Zhu, J. X.; Huang, W.; Dou, S. X.; Sun, W. P. Direct hybridization of noble metal nanostructures on 2D metal-organic framework nanosheets to catalyze hydrogen evolution. Nano Lett. 2019, 19, 8447–8453.

Kibsgaard, J.; Chorkendorff, I. Considerations for the scaling-up of water splitting catalysts. Nat. Energy 2019, 4, 430–433.

Lu, K.; Liu, Y. Z.; Lin, F.; Cordova, I. A.; Gao, S. Y.; Li, B. M.; Peng, B.; Xu, H. P.; Kaelin, J.; Coliz, D. et al. Li_xNiO/Ni heterostructure with strong basic lattice oxygen enables electrocatalytic hydrogen evolution with Pt-like activity. J. Am. Chem. Soc. 2020, 142, 12613–12619.

Podjaski, F.; Weber, D.; Zhang, S. Y.; Diehl, L.; Eger, R.; Duppel, V.; Alarcón-Lladó, E.; Richter, G.; Haase, F.; Morral, A. F. I. et al. Rational strain engineering in delafossite oxides for highly efficient hydrogen evolution catalysis in acidic media. Nat. Catal. 2020, 3, 55–63.

Zhu, C. Z.; Shi, Q. R.; Feng, S.; Du, D.; Lin, Y. H. Single-atom catalysts for electrochemical water splitting. ACS Energy Lett. 2018, 3, 1713–1721.

Chen, Y.; Rao, Y.; Wang, R. Z.; Yu, Y. N.; Li, Q. L.; Bao, S. J.; Xu, M. W.; Yue, Q.; Zhang, Y. N.; Kang, Y. J. Interfacial engineering of Ni/V₂O₃ for hydrogen evolution reaction. Nano Res. 2020, 13, 2407–2412.

Gong, M.; Wang, D. Y.; Chen, C. C.; Hwang, B. J.; Dai, H. J. A mini review on nickel-based electrocatalysts for alkaline hydrogen evolution reaction. Nano Res. 2016, 9, 28–46.

Lao, M. M.; Rui, K.; Zhao, G. Q.; Cui, P. X.; Zheng, X. S.; Dou, S. X.; Sun, W. P. Platinum/nickel bicarbonate heterostructures towards accelerated hydrogen evolution under alkaline conditions. Angew. Chem., Int. Ed. 2019, 58, 5432–5437.

Li, P.; Zhao, G. Q.; Cui, P. X.; Cheng, N. Y.; Lao, M. M.; Xu, X.; Dou, S. X.; Sun, W. P. Nickel single atom-decorated carbon nanosheets as multifunctional electrocatalyst supports toward efficient alkaline hydrogen evolution. Nano Energy 2021, 83, 105850.

Chao, T. T.; Luo, X.; Chen, W. X.; Jiang, B.; Ge, J. J.; Lin, Y.; Wu, G.; Wang, X. Q.; Hu, Y. M.; Zhuang, Z. B. et al. Atomically dispersed copper-platinum dual sites alloyed with palladium nanorings catalyze the hydrogen evolution reaction. Angew. Chem., Int. Ed. 2017, 56, 16047–16051.

Kuang, P. Y.; Wang, Y. R.; Zhu, B. C.; Xia, F. J.; Tung, C. W.; Wu, J. S.; Chen, H. M.; Yu, J. G. Pt single atoms supported on N-doped mesoporous hollow carbon spheres with enhanced electrocatalytic H₂-evolution activity. Adv. Mater. 2021, 33, 2008599.

Cao, L. L.; Luo, Q. Q.; Liu, W.; Lin, Y.; Liu, X. K.; Cao, Y. J.; Zhang, W.; Wu, Y. E.; Yang, J. L.; Yao, T. et al. Identification of single-atom active sites in carbon-based cobalt catalysts during electrocatalytic hydrogen evolution. Nat. Catal. 2019, 2, 134–141.

Liu, X.; Jiao, Y.; Zheng, Y.; Davey, K.; Qiao, S. Z. A computational study on Pt and Ru dimers supported on graphene for the hydrogen evolution reaction: New insight into the alkaline mechanism. J. Mater. Chem. A 2019, 7, 3648–3654.

Zhang, L. Z.; Jia, Y.; Liu, H. L.; Zhuang, L. Z.; Yan, X. C.; Lang, C. G.; Wang, X.; Yang, D. J.; Huang, K. K.; Feng, S. H. et al. Charge polarization from atomic metals on adjacent graphitic layers for enhancing the hydrogen evolution reaction. Angew. Chem., Int. Ed. 2019, 58, 9404–9408.

Cao, L. J.; Wang, X. L.; Yang, C.; Lu, J. J.; Shi, X. Y.; Zhu, H. W.; Liang, H. P. Highly active Fe/Pt single-atom bifunctional electrocatalysts on biomass-derived carbon. ACS Sustainable Chem. Eng. 2020, 9, 189–196.

Zeng, X. J.; Shui, J. L.; Liu, X. F.; Liu, Q. T.; Li, Y. C.; Shang, J. X.; Zheng, L. R.; Yu, R. H. Single-atom to single-atom grafting of Pt₁ onto Fe-N₄ center: Pt₁@Fe-N-C multifunctional electrocatalyst with significantly enhanced properties. Adv. Energy Mater. 2018, 8, 1701345.

Kumar, A.; Bui, V. Q.; Lee, J.; Wang, L. L.; Jadhav, A. R.; Liu, X. H.; Shao, X. D.; Liu, Y.; Yu, J. M.; Hwang, Y. et al. Moving beyond bimetallic-alloy to single-atom dimer atomic-interface for all-pH hydrogen evolution. Nat. Commun. 2021, 12, 6766.

Li, Q.; Wu, J. B.; Wu, T.; Jin, H. R.; Zhang, N.; Li, J.; Liang, W. X.; Liu, M. L.; Huang, L.; Zhou, J. Phase engineering of atomically thin perovskite oxide for highly active oxygen evolution. Adv. Funct. Mater. 2021, 31, 2102002.

Zhao, G. Q.; Li, P.; Cheng, N. Y.; Dou, S. X.; Sun, W. P. An Ir/Ni(OH)₂ heterostructured electrocatalyst for the oxygen evolution reaction: Breaking the scaling relation, stabilizing iridium(V), and beyond. Adv. Mater. 2020, 32, 2000872.

Chen, J. Y.; Cui, P. X.; Zhao, G. Q.; Rui, K.; Lao, M. M.; Chen, Y. P.; Zheng, X. S.; Jiang, Y. Z.; Pan, H. G.; Dou, S. X. et al. Low-coordinate iridium oxide confined on graphitic carbon nitride for highly efficient oxygen evolution. Angew. Chem., Int. Ed. 2019, 58, 12540–12544.

Seitz, L. C.; Dickens, C. F.; Nishio, K.; Hikita, Y.; Montoya, J.; Doyle, A.; Kirk, C.; Vojvodic, A.; Hwang, H. Y.; Norskov, J. K. et al. A highly active and stable IrO_x/SrIrO₃ catalyst for the oxygen evolution reaction. Science 2016, 353, 1011–1014.

Nong, H. N.; Falling, L. J.; Bergmann, A.; Klingenhof, M.; Tran, H. P.; Spöri, C.; Mom, R.; Timoshenko, J.; Zichittella, G.; Knop-Gericke, A. et al. Key role of chemistry versus bias in electrocatalytic oxygen evolution. Nature 2020, 587, 408–413.

Song, J. J.; Wei, C.; Huang, Z. F.; Liu, C. T.; Zeng, L.; Wang, X.; Xu, Z. J. A review on fundamentals for designing oxygen evolution electrocatalysts. Chem. Soc. Rev. 2020, 49, 2196–2214.

Huang, L. A.; He, Z. S.; Guo, J. F.; Pei, S. E.; Shao, H. B.; Wang, J. M. Photodeposition fabrication of hierarchical layered Co-doped Ni oxyhydroxide (Ni_xCo_1−xOOH) catalysts with enhanced electrocatalytic performance for oxygen evolution reaction. Nano Res. 2020, 13, 246–254.

Wang, T. J.; Liu, X. Y.; Li, Y.; Li, F. M.; Deng, Z. W.; Chen, Y. Ultrasonication-assisted and gram-scale synthesis of Co-LDH nanosheet aggregates for oxygen evolution reaction. Nano Res. 2019, 13, 79–85.

Zhang, B.; Zheng, X. L.; Voznyy, O.; Comin, R.; Bajdich, M.; Garcia-Melchor, M.; Han, L. L.; Xu, J. X.; Liu, M.; Zheng, L. R. et al. Homogeneously dispersed multimetal oxygen-evolving catalysts. Science 2016, 352, 333–337.

Mefford, J. T.; Akbashev, A. R.; Kang, M.; Bentley, C. L.; Gent, W. E.; Deng, H. D.; Alsem, D. H.; Yu, Y. S.; Salmon, N. J.; Shapiro, D. A. et al. Correlative operando microscopy of oxygen evolution electrocatalysts. Nature 2021, 593, 67–73.

Chen, Y. J.; Gao, R.; Ji, S. F.; Li, H. J.; Tang, K.; Jiang, P.; Hu, H. B.; Zhang, Z. D.; Hao, H. G.; Qu, Q. Y. et al. Atomic-level modulation of electronic density at cobalt single-atom sites derived from metal-organic frameworks: Enhanced oxygen reduction performance. Angew. Chem., Int. Ed. 2021, 60, 3212–3221.

Wei, B.; Fu, Z. H.; Legut, D.; Germann, T. C.; Du, S. Y.; Zhang, H. J.; Francisco, J. S.; Zhang, R. F. Rational design of highly stable and active MXene-based bifunctional ORR/OER double-atom catalysts. Adv. Mater. 2021, 33, 2102595.

Wu, C. C.; Zhang, X. M.; Xia, Z. X.; Shu, M.; Li, H. Q.; Xu, X. L.; Si, R.; Rykov, A. I.; Wang, J. H.; Yu, S. S. et al. Insight into the role of Ni-Fe dual sites in the oxygen evolution reaction based on atomically metal-doped polymeric carbon nitride. J. Mater. Chem. A 2019, 7, 14001–14010.

Xiao, M. L.; Zhu, J. B.; Li, S.; Li, G. R.; Liu, W. W.; Deng, Y. P.; Bai, Z. Y.; Ma, L.; Feng, M.; Wu, T. P. et al. 3D-orbital occupancy regulated Ir-Co atomic pair toward superior bifunctional oxygen electrocatalysis. ACS Catal. 2021, 11, 8837–8846.

Zhu, X. F.; Zhang, D. T.; Chen, C. J.; Zhang, Q. R.; Liu, R. S.; Xia, Z. H.; Dai, L. M.; Amal, R.; Lu, X. Y. Harnessing the interplay of Fe-Ni atom pairs embedded in nitrogen-doped carbon for bifunctional oxygen electrocatalysis. Nano Energy 2020, 71, 104597.

Wan, W. C.; Zhao, Y. G.; Wei, S. Q.; Triana, C. A.; Li, J. G.; Arcifa, A.; Allen, C. S.; Cao, R.; Patzke, G. R. Mechanistic insight into the active centers of single/dual-atom Ni/Fe-based oxygen electrocatalysts. Nat. Commun. 2021, 12, 5589.

Zhao, C. X.; Li, B. Q.; Liu, J. N.; Zhang, Q. Intrinsic electrocatalytic activity regulation of M-N-C single-atom catalysts for the oxygen reduction reaction. Angew. Chem., Int. Ed. 2021, 60, 4448–4463.

Bu, L. Z.; Zhang, N.; Guo, S. J.; Zhang, X.; Li, J.; Yao, J. L.; Wu, T.; Lu, G.; Ma, J. Y.; Su, D. et al. Biaxially strained PtPb/Pt core/shell nanoplate boosts oxygen reduction catalysis. Science 2016, 354, 1410–1414.

Escudero-Escribano, M.; Malacrida, P.; Hansen, M. H.; Vej-Hansen, U. G.; Velázquez-Palenzuela, A.; Tripkovic, V.; Schiøtz, J.; Rossmeisl, J.; Stephens, I. E. L.; Chorkendorff, I. Tuning the activity of Pt alloy electrocatalysts by means of the lanthanide contraction. Science 2016, 352, 73–76.

Li, M. F.; Zhao, Z. P.; Cheng, T.; Fortunelli, A.; Chen, C. Y.; Yu, R.; Zhang, Q. H.; Gu, L.; Merinov, B. V.; Lin, Z. Y. et al. Ultrafine jagged platinum nanowires enable ultrahigh mass activity for the oxygen reduction reaction. Science 2016, 354, 1414–1419.

Wang, H. T.; Xu, S. C.; Tsai, C.; Li, Y. Z.; Liu, C.; Zhao, J.; Liu, Y. Y.; Yuan, H. Y.; Abild-Pedersen, F.; Prinz, F. B. et al. Direct and continuous strain control of catalysts with tunable battery electrode materials. Science 2016, 354, 1031–1036.

Luo, M. C.; Zhao, Z. L.; Zhang, Y. L.; Sun, Y. J.; Xing, Y.; Lv, F.; Yang, Y.; Zhang, X.; Hwang, S.; Qin, Y. N. et al. PdMo bimetallene for oxygen reduction catalysis. Nature 2019, 574, 81–85.

Tian, X. L.; Zhao, X.; Su, Y. Q.; Wang, L. J.; Wang, H. M.; Dang, D.; Chi, B.; Liu, H. F.; Hensen, E. J. M.; Lou, X. W. et al. Engineering bunched Pt-Ni alloy nanocages for efficient oxygen reduction in practical fuel cells. Science 2019, 366, 850–856.

Wang, L.; Zeng, Z. H.; Gao, W. P.; Maxson, T.; Raciti, D.; Giroux, M.; Pan, X. Q.; Wang, C.; Greeley, J. Tunable intrinsic strain in two-dimensional transition metal electrocatalysts. Science 2019, 363, 870–874.

Chen, Y. P.; Cai, J. Y.; Li, P.; Zhao, G. Q.; Wang, G. M.; Jiang, Y. Z.; Chen, J.; Dou, S. X.; Pan, H. G.; Sun, W. P. Hexagonal boron nitride as a multifunctional support for engineering efficient electrocatalysts toward the oxygen reduction reaction. Nano Lett. 2020, 20, 6807–6814.

Wang, Y.; Wang, D. S.; Li, Y. D. Rational design of single-atom site electrocatalysts: From theoretical understandings to practical applications. Adv. Mater. 2021, 33, 2008151.

Zhang, Q.; Zhang, X. X.; Wang, J. Z.; Wang, C. W. Graphene-supported single-atom catalysts and applications in electrocatalysis. Nanotechnology 2021, 32, 032001.

Zhuang, Z. C.; Li, Y.; Li, Y. H.; Huang, J. Z.; Wei, B.; Sun, R.; Ren, Y. J.; Ding, J.; Zhu, J. X.; Lang, Z. Q. et al. Atomically dispersed nonmagnetic electron traps improve oxygen reduction activity of perovskite oxides. Energy Environ. Sci. 2021, 14, 1016–1028.

Wang, Y.; Wang, D. S.; Li, Y. D. Atom-level interfacial synergy of single-atom site catalysts for electrocatalysis. J. Energy Chem. 2022, 65, 103–115.

Yang, J. R.; Li, W. H.; Wang, D. S.; Li, Y. D. Single-atom materials: Small structures determine macroproperties. Small Struct. 2021, 2, 2000051.

Gong, S. P.; Wang, C. L.; Jiang, P.; Hu, L.; Lei, H.; Chen, Q. W. Designing highly efficient dual-metal single-atom electrocatalysts for the oxygen reduction reaction inspired by biological enzyme systems. J. Mater. Chem. A 2018, 6, 13254–13262.

Zhou, Y. D.; Yang, W.; Utetiwabo, W.; Lian, Y. M.; Yin, X.; Zhou, L.; Yu, P. W.; Chen, R. J.; Sun, S. R. Revealing of active sites and catalytic mechanism in N-coordinated Fe, Ni dual-doped carbon with superior acidic oxygen reduction than single-atom catalyst. J. Phys. Chem. Lett. 2020, 11, 1404–1410.

Du, C.; Gao, Y. J.; Chen, H. Q.; Li, P.; Zhu, S. Y.; Wang, J. G.; He, Q. G.; Chen, W. A Cu and Fe dual-atom nanozyme mimicking cytochrome c oxidase to boost the oxygen reduction reaction. J. Mater. Chem. A 2020, 8, 16994–17001.

Wang, B. W.; Zou, J. X.; Shen, X. C.; Yang, Y. C.; Hu, G. Z.; Li, W.; Peng, Z. M.; Banham, D.; Dong, A. G.; Zhao, D. Y. Nanocrystal supracrystal-derived atomically dispersed Mn-Fe catalysts with enhanced oxygen reduction activity. Nano Energy 2019, 63, 103851.

Liu, D. X.; Wang, B.; Li, H. G.; Huang, S. F.; Liu, M. M.; Wang, J.; Wang, Q. J.; Zhang, J. J.; Zhao, Y. F. Distinguished Zn, Co-Nx-C-Sy active sites confined in dentric carbon for highly efficient oxygen reduction reaction and flexible Zn-air Batteries. Nano Energy 2019, 58, 277–283.

Zhang, D. Y.; Chen, W. X.; Li, Z.; Chen, Y. J.; Zheng, L. R.; Gong, Y.; Li, Q. H.; Shen, R. G.; Han, Y. H.; Cheong, W. C. et al. Isolated Fe and Co dual active sites on nitrogen-doped carbon for a highly efficient oxygen reduction reaction. Chem. Commun. 2018, 54, 4274–4277.

Xiao, M. L.; Zhang, H.; Chen, Y. T.; Zhu, J. B.; Gao, L. Q.; Jin, Z.; Ge, J. J.; Jiang, Z.; Chen, S. L.; Liu, C. P. et al. Identification of binuclear Co₂N₅ active sites for oxygen reduction reaction with more than one magnitude higher activity than single atom CoN₄ site. Nano Energy 2018, 46, 396–403.

Yang, G. G.; Zhu, J. W.; Yuan, P. F.; Hu, Y. F.; Qu, G.; Lu, B. A.; Xue, X. Y.; Yin, H. B.; Cheng, W. Z.; Cheng, J. Q. et al. Regulating Fe-spin state by atomically dispersed Mn-N in Fe-N-C catalysts with high oxygen reduction activity. Nat. Commun. 2021, 12, 1734.

Liu, M.; Li, N.; Cao, S. F.; Wang, X. M.; Lu, X. Q.; Kong, L. J.; Xu, Y. H.; Bu, X. H. A “pre-constrained metal twins” strategy to prepare efficient dual-metal-atom catalysts for cooperative oxygen electrocatalysis. Adv. Mater. 2022, 34, 2107421.

Zhao, R.; Liang, Z. B.; Gao, S.; Yang, C.; Zhu, B. J.; Zhao, J. L.; Qu, C.; Zou, R. Q.; Xu, Q. Puffing up energetic metal-organic frameworks to large carbon networks with hierarchical porosity and atomically dispersed metal sites. Angew. Chem., Int. Ed. 2019, 58, 1975–1979.

Ye, W.; Chen, S. M.; Lin, Y.; Yang, L.; Chen, S. J.; Zheng, X. S.; Qi, Z. M.; Wang, C. M.; Long, R.; Chen, M. et al. Precisely tuning the number of fe atoms in clusters on N-doped carbon toward acidic oxygen reduction reaction. Chem 2019, 5, 2865–2878.

Han, A.; Wang, X. J.; Tang, K.; Zhang, Z. D.; Ye, C. L.; Kong, K. J.; Hu, H. B.; Zheng, L. R.; Jiang, P.; Zhao, C. X. et al. An adjacent atomic platinum site enables single-atom iron with high oxygen reduction reaction performance. Angew. Chem., Int. Ed. 2021, 60, 19262–19271.

Lu, Z. Y.; Wang, B.; Hu, Y. F.; Liu, W.; Zhao, Y. F.; Yang, R. O.; Li, Z. P.; Luo, J.; Chi, B.; Jiang, Z. et al. An isolated zinc-cobalt atomic pair for highly active and durable oxygen reduction. Angew. Chem., Int. Ed. 2019, 58, 2622–2626.

Kong, F. P.; Si, R. T.; Chen, N.; Wang, Q.; Li, J. J.; Yin, G. P.; Gu, M.; Wang, J. J.; Liu, L. M.; Sun, X. L. Origin of hetero-nuclear Au-Co dual atoms for efficient acidic oxygen reduction. Appl. Catal. B:Environ. 2022, 301, 120782.

Lin, S.; Diercks, C. S.; Zhang, Y. B.; Kornienko, N.; Nichols, E. M.; Zhao, Y. B.; Paris, A. R.; Kim, D.; Yang, P. D.; Yaghi, O. M. et al. Covalent organic frameworks comprising cobalt porphyrins for catalytic CO₂ reduction in water. Science 2015, 349, 1208–1213.

Nitopi, S.; Bertheussen, E.; Scott, S. B.; Liu, X. Y.; Engstfeld, A. K.; Horch, S.; Seger, B.; Stephens, I. E. L.; Chan, K.; Hahn, C. et al. Progress and perspectives of electrochemical CO₂ reduction on copper in aqueous electrolyte. Chem. Rev. 2019, 119, 7610–7672.

De Luna, P.; Hahn, C.; Higgins, D.; Jaffer, S. A.; Jaramillo, T. F.; Sargent, E. H. What would it take for renewably powered electrosynthesis to displace petrochemical processes. Science 2019, 364, eaav3506.

Trindell, J. A.; Duan, Z. Y.; Henkelman, G.; Crooks, R. M. Well-defined nanoparticle electrocatalysts for the refinement of theory. Chem. Rev. 2020, 120, 814–850.

Mori, K.; Taga, T.; Yamashita, H. Isolated single-atomic Ru catalyst bound on a layered double hydroxide for hydrogenation of CO₂ to formic acid. ACS Catal. 2017, 7, 3147–3151.

Cheng, N. C.; Zhang, L.; Doyle-Davis, K.; Sun, X. L. Single-atom catalysts: From design to application. Electrochem. Energy Rev. 2019, 2, 539–573.

Chen, S. H.; Wang, B. Q.; Zhu, J. X.; Wang, L. Q.; Ou, H. H.; Zhang, Z. D.; Liang, X.; Zheng, L. R.; Zhou, L.; Su, Y. Q. et al. Lewis acid site-promoted single-atomic Cu catalyzes electrochemical CO₂ methanation. Nano Lett. 2021, 21, 7325–7331.

Jiang, Z. L.; Wang, T.; Pei, J. J.; Shang, H. S.; Zhou, D. N.; Li, H. J.; Dong, J. C.; Wang, Y.; Cao, R.; Zhuang, Z. B. et al. Discovery of main group single Sb-N₄ active sites for CO₂ electroreduction to formate with high efficiency. Energy Environ. Sci. 2020, 13, 2856–2863.

Sun, X. H.; Tuo, Y. X.; Ye, C. L.; Chen, C.; Lu, Q.; Li, G. N.; Jiang, P.; Chen, S. H.; Zhu, P.; Ma, M. et al. Phosphorus induced electron localization of single iron sites for boosted CO₂ electroreduction reaction. Angew. Chem., Int. Ed. 2021, 60, 23614–23618.

Zhao, J.; Zhao, J. X.; Li, F. Y.; Chen, Z. F. Copper dimer supported on a C₂N layer as an efficient electrocatalyst for CO₂ reduction reaction: A computational study. J. Phys. Chem. C 2018, 122, 19712–19721.

Ouyang, Y. X.; Shi, L.; Bai, X. W.; Li, Q.; Wang, J. L. Breaking scaling relations for efficient CO₂ electrochemical reduction through dual-atom catalysts. Chem. Sci. 2020, 11, 1807–1813.

Li, Y. Z.; Wei, B.; Zhu, M. H.; Chen, J. C.; Jiang, Q. K.; Yang, B.; Hou, Y.; Lei, L. C.; Li, Z. J.; Zhang, R. F. et al. Synergistic effect of atomically dispersed Ni-Zn pair sites for enhanced CO₂ electroreduction. Adv. Mater. 2021, 33, 2102212.

Zhu, W. J.; Zhang, L.; Liu, S. H.; Li, A.; Yuan, X. T.; Hu, C. L.; Zhang, G.; Deng, W. Y.; Zang, K. T.; Luo, J. et al. Enhanced CO₂ electroreduction on neighboring Zn/Co monomers by electronic effect. Angew. Chem., Int. Ed. 2020, 59, 12664–12668.

Pei, J. J.; Wang, T.; Sui, R.; Zhang, X. J.; Zhou, D. N.; Qin, F. J.; Zhao, X.; Liu, Q. H.; Yan, W. S.; Dong, J. C. et al. N-Bridged Co-N-Ni: New bimetallic sites for promoting electrochemical CO₂ reduction. Energy Environ. Sci. 2021, 14, 3019–3028.

Wei, X. F.; Wei, S. X.; Cao, S. F.; Hu, Y. Y.; Zhou, S. N.; Liu, S. Y.; Wang, Z. J.; Lu, X. Q. Cu acting as Fe activity promoter in dual-atom Cu/Fe-NC catalyst in CO₂RR to C1 products. Appl. Surf. Sci. 2021, 564, 150423.

Xie, W. F.; Li, H.; Cui, G. Q.; Li, J. B.; Song, Y. K.; Li, S. J.; Zhang, X.; Lee, J. Y.; Shao, M. F.; Wei, M. NiSn atomic pair on an integrated electrode for synergistic electrocatalytic CO₂ reduction. Angew. Chem., Int. Ed. 2021, 60, 7382–7388.

Sun, M. J.; Gong, Z. W.; Yi, J. D.; Zhang, T.; Chen, X. D.; Cao, R. A highly efficient diatomic nickel electrocatalyst for CO₂ reduction. Chem. Commun. 2020, 56, 8798–8801.

Li, Y. F.; Chen, C.; Cao, R.; Pan, Z. W.; He, H.; Zhou, K. B. Dual-atom Ag₂/graphene catalyst for efficient electroreduction of CO₂ to CO. Appl. Catal. B:Environ. 2020, 268, 118747.

Jiao, J. Q.; Lin, R.; Liu, S. J.; Cheong, W. C.; Zhang, C.; Chen, Z.; Pan, Y.; Tang, J. G.; Wu, K. L.; Hung, S. F. et al. Copper atom-pair catalyst anchored on alloy nanowires for selective and efficient electrochemical reduction of CO₂. Nat. Chem. 2019, 11, 222–228.

Yang, J. R.; Zeng, D. Q.; Li, J.; Dong, L. Q.; Ong, W. J.; He, Y. L. A highly efficient Fenton-like catalyst based on isolated diatomic Fe-Co anchored on N-doped porous carbon. Chem. Eng. J. 2021, 404, 126376.

Wang, Y.; Park, B. J.; Paidi, V. K.; Huang, R.; Lee, Y.; Noh, K. J.; Lee, K. S.; Han, J. W. Precisely constructing orbital coupling-modulated dual-atom fe pair sites for synergistic CO₂ electroreduction. ACS Energy Lett. 2022, 7, 640–649.

Cheng, H. Y.; Wu, X. M.; Feng, M. M.; Li, X. C.; Lei, G. P.; Fan, Z. H.; Pan, D. W.; Cui, F. J.; He, G. H. Atomically dispersed Ni/Cu dual sites for boosting the CO₂ reduction reaction. ACS Catal. 2021, 11, 12673–12681.

Jiao, L.; Zhu, J. T.; Zhang, Y.; Yang, W. J.; Zhou, S. Y.; Li, A. W.; Xie, C. F.; Zheng, X. S.; Zhou, W.; Yu, S. H. et al. Non-bonding interaction of neighboring Fe and Ni single-atom pairs on MOF-derived N-doped carbon for enhanced CO₂ electroreduction. J. Am. Chem. Soc. 2021, 143, 19417–19424.

Bao, D.; Zhang, Q.; Meng, F. L.; Zhong, H. X.; Shi, M. M.; Zhang, Y.; Yan, J. M.; Jiang, Q.; Zhang, X. B. Electrochemical reduction of N₂ under ambient conditions for artificial N₂ fixation and renewable energy storage using N₂/NH₃ cycle. Adv. Mater. 2017, 29, 1604799.

van der Ham, C. J. M.; Koper, M. T. M.; Hetterscheid, D. G. H. Challenges in reduction of dinitrogen by proton and electron transfer. Chem. Soc. Rev. 2014, 43, 5183–5191.

Liu, J. C.; Ma, X. L.; Li, Y.; Wang, Y. G.; Xiao, H.; Li, J. Heterogeneous Fe₃ single-cluster catalyst for ammonia synthesis via an associative mechanism. Nat. Commun. 2018, 9, 1610.

Liu, J. Y.; Kong, X.; Zheng, L. R.; Guo, X.; Liu, X. F.; Shui, J. L. Rare earth single-atom catalysts for nitrogen and carbon dioxide reduction. ACS Nano 2020, 14, 1093–1101.

Qiu, Y.; Peng, X. Y.; Lü, F.; Mi, Y. Y.; Zhuo, L. C.; Ren, J. Q.; Liu, X. J.; Luo, J. Single-atom catalysts for the electrocatalytic reduction of nitrogen to ammonia under ambient conditions. Chem. Asian J. 2019, 14, 2770–2779.

Liu, S. S.; Qian, T.; Wang, M. F.; Ji, H. Q.; Shen, X. W.; Wang, C.; Yan, C. L. Proton-filtering covalent organic frameworks with superior nitrogen penetration flux promote ambient ammonia synthesis. Nat. Catal. 2021, 4, 322–331.

Chen, Z.; Zhao, J. X.; Cabrera, C. R.; Chen, Z. F. Computational screening of efficient single-atom catalysts based on graphitic carbon nitride (g-C₃N₄) for nitrogen electroreduction. Small Methods 2019, 3, 1800368.

Tao, H. C.; Choi, C.; Ding, L. X.; Jiang, Z.; Han, Z. S.; Jia, M. W.; Fan, Q.; Gao, Y. N.; Wang, H. H.; Robertson, A. W. et al. Nitrogen fixation by Ru single-atom electrocatalytic reduction. Chem 2019, 5, 204–214.

Liu, X.; Jiao, Y.; Zheng, Y.; Jaroniec, M.; Qiao, S. Z. Building up a picture of the electrocatalytic nitrogen reduction activity of transition metal single-atom catalysts. J. Am. Chem. Soc. 2019, 141, 9664–9672.

Qian, Y. M.; Liu, Y. Y.; Zhao, Y.; Zhang, X. H.; Yu, G. H. Single vs. double atom catalyst for N₂ activation in nitrogen reduction reaction: A DFT perspective. EcoMat 2020, 2, e12014.

Yang, L.; Ma, X.; Xu, Y. Y.; Xu, J. Y.; Song, Y. D. A DFT study on application of dual-atom Fe₂/phthalocyanine catalyst for N₂ reduction reaction. Int. J. Electrochem. Sci. 2020, 15, 9698–9706.

Chen, Z. W.; Yan, J. M.; Jiang, Q. Single or double: Which is the altar of atomic catalysts for nitrogen reduction reaction. Small Methods 2019, 3, 1800291.

He, T. W.; Puente Santiago, A. R.; Du, A. J. Atomically embedded asymmetrical dual-metal dimers on N-doped graphene for ultra-efficient nitrogen reduction reaction. J. Catal. 2020, 388, 77–83.

Zheng, X. B.; Li, P.; Zhu, H. J.; Rui, K.; Zhao, G. Q.; Shu, J.; Xu, X.; Sun, W. P.; Dou, S. X. New insights into understanding the exceptional electrochemical performance of P2-type manganese-based layered oxide cathode for sodium ion batteries. Energy Stor. Mater. 2018, 15, 257–265.

Van der Ven, A.; Deng, Z.; Banerjee, S.; Ong, S. P. Rechargeable alkali-ion battery materials: Theory and computation. Chem. Rev. 2020, 120, 6977–7019.

Zheng, X. B.; Li, P.; Zhu, H. J.; Zhao, G. Q.; Rui, K.; Shu, J.; Xu, X.; Wang, X. L.; Sun, W. P.; Dou, S. X. Understanding the structural and chemical evolution of layered potassium titanates for sodium ion batteries. Energy Stor. Mater. 2020, 25, 502–509.

Service, R. F. Zinc aims to beat lithium batteries at storing energy. Science 2021, 372, 890–891.

Sun, W.; Wang, F.; Zhang, B.; Zhang, M. Y.; Küpers, V.; Ji, X.; Theile, C.; Bieker, P.; Xu, K.; Wang, C. S. et al. A rechargeable zinc-air battery based on zinc peroxide chemistry. Science 2021, 371, 46–51.

Zhou, J. W.; Cheng, J. L.; Wang, B.; Peng, H. S.; Lu, J. Flexible metal-gas batteries: A potential option for next-generation power accessories for wearable electronics. Energy Environ. Sci. 2020, 13, 1933–1970.

Zhou, T. P.; Zhang, N.; Wu, C. Z.; Xie, Y. Surface/interface nanoengineering for rechargeable Zn-air batteries. Energy Environ. Sci. 2020, 13, 1132–1153.

Wu, J. B.; Zhou, H.; Li, Q.; Chen, M.; Wan, J.; Zhang, N.; Xiong, L. K.; Li, S.; Xia, B. Y.; Feng, G. et al. Densely populated isolated single Co-N site for efficient oxygen electrocatalysis. Adv. Energy Mater. 2019, 9, 1900149.

Zhao, C. X.; Liu, J. N.; Wang, J.; Ren, D.; Yu, J.; Chen, X.; Li, B. Q.; Zhang, Q. A ΔE = 0.63 V bifunctional oxygen electrocatalyst enables high-rate and long-cycling zinc-air batteries. Adv. Mater. 2021, 33, 2008606.

Xiao, M. L.; Xing, Z. H.; Jin, Z.; Liu, C. P.; Ge, J. J.; Zhu, J. B.; Wang, Y.; Zhao, X.; Chen, Z. W. Preferentially engineering FeN₄ edge sites onto graphitic nanosheets for highly active and durable oxygen electrocatalysis in rechargeable Zn-air batteries. Adv. Mater. 2020, 32, 2004900.

Zhang, W. M.; Liu, Y. Q.; Zhang, L. P.; Chen, J. Recent advances in isolated single-atom catalysts for zinc air batteries: A focus review. Nanomaterials 2019, 9, 1402.

Peng, L. S.; Shang, L.; Zhang, T. R.; Waterhouse, G. I. N. Recent advances in the development of single-atom catalysts for oxygen electrocatalysis and zinc-air batteries. Adv. Energy Mater. 2020, 10, 2003018.

Li, Z. H.; He, H. Y.; Cao, H. B.; Sun, S. M.; Diao, W. L.; Gao, D. L.; Lu, P. L.; Zhang, S. S.; Guo, Z.; Li, M. J. et al. Atomic Co/Ni dual sites and Co/Ni alloy nanoparticles in N-doped porous Janus-like carbon frameworks for bifunctional oxygen electrocatalysis. Appl. Catal. B:Environ 2019, 240, 112–121.

Chong, L. N.; Wen, J. G.; Kubal, J.; Sen, F. G.; Zou, J. X.; Greeley, J.; Chan, M.; Barkholtz, H.; Ding, W. J.; Liu, D. J. Ultralow-loading platinum-cobalt fuel cell catalysts derived from imidazolate frameworks. Science 2018, 362, 1276–1281.

Chung, H. T.; Cullen, D. A.; Higgins, D.; Sneed, B. T.; Holby, E. F.; More, K. L.; Zelenay, P. Direct atomic-level insight into the active sites of a high-performance PGM-free ORR catalyst. Science 2017, 357, 479–484.

He, Y. H.; Liu, S. W.; Priest, C.; Shi, Q. R.; Wu, G. Atomically dispersed metal-nitrogen-carbon catalysts for fuel cells: Advances in catalyst design, electrode performance, and durability improvement. Chem. Soc. Rev. 2020, 49, 3484–3524.

Gao, C.; Low, J.; Long, R.; Kong, T. T.; Zhu, J. F.; Xiong, Y. J. Heterogeneous single-atom photocatalysts: Fundamentals and applications. Chem. Rev. 2020, 120, 12175–12216.

Liu, L. C.; Corma, A. Metal catalysts for heterogeneous catalysis: From single atoms to nanoclusters and nanoparticles. Chem. Rev. 2018, 118, 4981–5079.

Li, F. Y.; Chen, Z. F. Cu dimer anchored on C₂N monolayer: Low-cost and efficient Bi-atom catalyst for CO oxidation. Nanoscale 2018, 10, 15696–15705.

Wang, Q.; Jin, B. J.; Hu, M.; Jia, C. Y.; Li, X.; Sharman, E.; Jiang, J. N-doped graphene-supported diatomic Ni-Fe catalyst for synergistic oxidation of CO. J. Phys. Chem. C 2021, 125, 5616–5622.

Li, F. Y.; Liu, X. Y.; Chen, Z. F. 1 + 1’ > 2: Heteronuclear biatom catalyst outperforms its homonuclear counterparts for CO oxidation. Small Methods 2019, 3, 1800480.

Zhou, P.; Hou, X. G.; Chao, Y. G.; Yang, W. X.; Zhang, W. Y.; Mu, Z. J.; Lai, J. P.; Lv, F.; Yang, K.; Liu, Y. X. et al. Synergetic interaction between neighboring platinum and ruthenium monomers boosts CO oxidation. Chem. Sci. 2019, 10, 5898–5905.

Fu, J. H.; Dong, J. H.; Si, R.; Sun, K. J.; Zhang, J. Y.; Li, M. R.; Yu, N. N.; Zhang, B. S.; Humphrey, M. G.; Fu, Q. et al. Synergistic effects for enhanced catalysis in a dual single-atom catalyst. ACS Catal. 2021, 11, 1952–1961.

Ji, S. F.; Chen, Y. J.; Zhao, S.; Chen, W. X.; Shi, L. J.; Wang, Y.; Dong, J. C.; Li, Z.; Li, F. W.; Chen, C. et al. Atomically dispersed ruthenium species inside metal-organic frameworks: Combining the high activity of atomic sites and the molecular sieving effect of MOFs. Angew. Chem., Int. Ed. 2019, 58, 4271–4275.

Liang, J. X.; Lin, J.; Liu, J. Y.; Wang, X. D.; Zhang, T.; Li, J. Dual metal active sites in an Ir₁/FeO_x single-atom catalyst: A redox mechanism for the water-gas shift reaction. Angew. Chem., Int. Ed. 2020, 59, 12968–12975.

Ni, W. P.; Liu, Z. X.; Guo, X. G.; Zhang, Y.; Ma, C.; Deng, Y. J.; Zhang, S. G. Dual single-cobalt atom-based carbon electrocatalysts for efficient CO₂-to-syngas conversion with industrial current densities. Appl. Catal. B:Environ. 2021, 291, 120092.

Ao, X.; Zhang, W.; Zhao, B. T.; Ding, Y.; Nam, G.; Soule, L.; Abdelhafiz, A.; Wang, C. D.; Liu, M. L. Atomically dispersed Fe-N-C decorated with Pt-alloy core–shell nanoparticles for improved activity and durability towards oxygen reduction. Energy Environ. Sci. 2020, 13, 3032–3040.

Li, X. Y.; Rong, H. P.; Zhang, J. T.; Wang, D. S.; Li, Y. D. Modulating the local coordination environment of single-atom catalysts for enhanced catalytic performance. Nano Res. 2020, 13, 1842–1855.

Hai, X.; Xi, S. B.; Mitchell, S.; Harrath, K.; Xu, H. M.; Akl, D. F.; Kong, D. B.; Li, J.; Li, Z. J.; Sun, T. et al. Scalable two-step annealing method for preparing ultra-high-density single-atom catalyst libraries. Nat. Nanotechnol. 2022, 17, 174–181.

Lai, W. H.; Zhang, L. F.; Hua, W. B.; Indris, S.; Yan, Z. C.; Hu, Z.; Zhang, B. W.; Liu, Y. N.; Wang, L.; Liu, M. et al. Generalπ-electron-assisted strategy for Ir, Pt, Ru, Pd, Fe, Ni single-atom electrocatalysts with bifunctional active sites for highly efficient water splitting. Angew. Chem., Int. Ed. 2019, 58, 11868–11873.

Zheng, T. T.; Liu, C. X.; Guo, C. X.; Zhang, M. L.; Li, X.; Jiang, Q.; Xue, W. Q.; Li, H. L.; Li, A. W.; Pao, C. W. et al. Copper-catalysed exclusive CO₂ to pure formic acid conversion via single-atom alloying. Nat. Nanotechnol. 2021, 16, 1386–1393.