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Nano Research 2022, 15(8): 7304-7312 https://doi.org/10.1007/s12274-022-4336-0
Research Article | Issue | Published: 10 May 2022

Oxygen vacancy-engineered BaTiO3 nanoparticles for synergistic cancer photothermal, photodynamic, and catalytic therapy

Show Author's Information Yiming Ding1,2,§,  Zhuo Wang2,§,  Zeyu Zhang1,2,  Yunchao Zhao1,2,  Shangyu Yang3,4,  Yalong Zhang1,2,  Shuncheng Yao2,3,  Shaobo Wang1,2,  Tian Huang1,2,  Yang Zhang3,4( ),  Linlin Li1,2,5( )
School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, School of Physical Science & Technology, Guangxi University, Nanning 530004, China
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China
Key Laboratory of Semiconductor Material Sciences, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

§ Yiming Ding and Zhuo Wang contributed equally to this work.

Keywords:
oxygen vacancy, BaTiO3, photodynamic therapy, photothermal therapy, peroxidase
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Ding Y, Wang Z, Zhang Z, et al. Oxygen vacancy-engineered BaTiO3 nanoparticles for synergistic cancer photothermal, photodynamic, and catalytic therapy. Nano Research, 2022, 15(8): 7304-7312. https://doi.org/10.1007/s12274-022-4336-0
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Abstract Full text Electronic supplementary material About this article

With the rapid development of photo-responsive nanomaterials, photo-triggered therapeutic strategies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have been new alternatives to current cancer therapeutic methods. Herein, we have fabricated oxygen vacancy-engineered BaTiO3 (BTO-Ov) nanoparticles (NPs) for near-infrared (NIR) light-triggered PTT, PDT, and catalytic therapy cooperatively for significantly improving cancer therapy. Compared to pristine BaTiO3 nanoparticles, BTO-Ov has stronger NIR light absorption and narrower band gap structure, which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT. Meanwhile, due to the existence of Ti3+, BTO-Ov also exhibits peroxidase (POD)-like activity to produce hydroxyl radical under tumor environment, which can be further improved under 808 nm light irradiation. Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation. The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform.


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About this article

Oxygen vacancy-engineered BaTiO3 nanoparticles for synergistic cancer photothermal, photodynamic, and catalytic therapy

Show Author's information Yiming Ding1,2,§, Zhuo Wang2,§, Zeyu Zhang1,2, Yunchao Zhao1,2, Shangyu Yang3,4, Yalong Zhang1,2, Shuncheng Yao2,3, Shaobo Wang1,2, Tian Huang1,2, Yang Zhang3,4( ), Linlin Li1,2,5( )
School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, School of Physical Science & Technology, Guangxi University, Nanning 530004, China
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China
Key Laboratory of Semiconductor Material Sciences, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

§ Yiming Ding and Zhuo Wang contributed equally to this work.

Abstract

With the rapid development of photo-responsive nanomaterials, photo-triggered therapeutic strategies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have been new alternatives to current cancer therapeutic methods. Herein, we have fabricated oxygen vacancy-engineered BaTiO3 (BTO-Ov) nanoparticles (NPs) for near-infrared (NIR) light-triggered PTT, PDT, and catalytic therapy cooperatively for significantly improving cancer therapy. Compared to pristine BaTiO3 nanoparticles, BTO-Ov has stronger NIR light absorption and narrower band gap structure, which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT. Meanwhile, due to the existence of Ti3+, BTO-Ov also exhibits peroxidase (POD)-like activity to produce hydroxyl radical under tumor environment, which can be further improved under 808 nm light irradiation. Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation. The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform.

Keywords: oxygen vacancy, BaTiO3, photodynamic therapy, photothermal therapy, peroxidase

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Publication history
Copyright
Acknowledgements

Publication history

Received: 25 February 2022
Revised: 16 March 2022
Accepted: 16 March 2022
Published: 10 May 2022
Issue date: August 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

The work was supported by the National Nature Science Foundation of China (Nos. 82072065 and 81471784), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDA16021103), and the National Youth Talent Support Program.

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