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Nano Research 2022, 15(8): 7295-7303 https://doi.org/10.1007/s12274-022-4332-4
Research Article | Issue | Published: 24 May 2022

Calixarene-integrated nano-drug delivery system for tumor-targeted delivery and tracking of anti-cancer drugs in vivo

Show Author's Information Lina Xu1,2,  Jingshan Chai1,2,  Ying Wang1,2,  Xinzhi Zhao1,2,  Dong-Sheng Guo3,  Linqi Shi1,2,  Zhanzhan Zhang1,2( ),  Yang Liu1,2 ( )
Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, China
State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
Keywords:
drug delivery system, calixarene, host–guest interaction, hypoxia-responsiveness, drug tracking
Topics:
Controlled drug delivery
Cite this article:
Xu L, Chai J, Wang Y, et al. Calixarene-integrated nano-drug delivery system for tumor-targeted delivery and tracking of anti-cancer drugs in vivo. Nano Research, 2022, 15(8): 7295-7303. https://doi.org/10.1007/s12274-022-4332-4
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Abstract Full text Electronic supplementary material About this article

Nano-drug delivery systems (nanoDDS) have been extensively investigated clinically to improve the therapeutic effect of anti-cancer drugs. However, the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general application. In this work, a calixarene-integrated nanoDDS (CanD) that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is presented. The hypoxia-responsive calixarene (SAC4A) exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B (RhB) under normoxic condition while decreasing the binding affinity under hypoxic condition, which leads to the drug release and fluorescence recovery simultaneously. Furthermore, the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability, resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in mice. Moreover, CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.


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Abstract
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Electronic supplementary material
About this article

Calixarene-integrated nano-drug delivery system for tumor-targeted delivery and tracking of anti-cancer drugs in vivo

Show Author's information Lina Xu1,2, Jingshan Chai1,2, Ying Wang1,2, Xinzhi Zhao1,2, Dong-Sheng Guo3, Linqi Shi1,2, Zhanzhan Zhang1,2( ), Yang Liu1,2 ( )
Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, China
State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

Nano-drug delivery systems (nanoDDS) have been extensively investigated clinically to improve the therapeutic effect of anti-cancer drugs. However, the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general application. In this work, a calixarene-integrated nanoDDS (CanD) that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is presented. The hypoxia-responsive calixarene (SAC4A) exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B (RhB) under normoxic condition while decreasing the binding affinity under hypoxic condition, which leads to the drug release and fluorescence recovery simultaneously. Furthermore, the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability, resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in mice. Moreover, CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.

Keywords: drug delivery system, calixarene, host–guest interaction, hypoxia-responsiveness, drug tracking

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Publication history
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Acknowledgements

Publication history

Received: 27 January 2022
Revised: 15 March 2022
Accepted: 16 March 2022
Published: 24 May 2022
Issue date: August 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by National Key Research and Development Programs of China (No. 2018YFA0209700), National Natural Science Foundation of China (NSFC, No. 22077073), Frontiers Science Center for New Organic Matter (No. 63181206), and Fundamental Research Funds for the Central Universities (Nankai University, No. 63206015).

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