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Nano Research 2022, 15(8): 7286-7294 https://doi.org/10.1007/s12274-022-4331-5
Research Article | Issue | Published: 26 April 2022

A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo

Show Author's Information Linping Fu1,2,  Jianhu Zhang3,  Chenchen Wu1,2,  Weizhi Wang5,  Dong Wang6( ),  Zhiyuan Hu1,2,3,4( ),  Zihua Wang1,3( )
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
School of Nanoscience and Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China
Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China
School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China
Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Keywords:
self-assembly, photothermal therapy, programmed death 1 (PD-1), targeting peptide, immune checkpoint blockade
Topics:
Theranostics
Cite this article:
Fu L, Zhang J, Wu C, et al. A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo. Nano Research, 2022, 15(8): 7286-7294. https://doi.org/10.1007/s12274-022-4331-5
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Abstract Full text Electronic supplementary material About this article

Programmed death 1 (PD-1) and its ligand PD-L1 are two typical immune checkpoints. Antibody-based immune checkpoint blockade (ICB) strategy targeting PD-1/PD-L1 achieved a significant therapeutic effect on cancer. However, due to the impenetrability of antibody drugs and the occurrence of immune-related adverse events, only a minority of patients benefit from this treatment. Peptides multimerization has been widely proved to be an effective method to improve receptor binding affinity through a multivalent synergistic effect. In this study, we report a novel peptide-aggregation-induced emission (AIE) hybrid supramolecular TAP, which can self-assemble into nanofibers through non-covalent interactions such as hydrogen bonds, with a specific nanomolar affinity to PD-L1 in vivo and in vitro. Combined with near-infrared agents, it can be used for tumor imaging and photothermal therapy, which enables photothermal ablation of cancer cells for generating tumor-associated antigen (TAA) and triggering a series of immunological events. Collectively, our work suggests that synthetic self-assembled peptide nanofibers can be developed as attractive platforms for active photothermal immunotherapies against cancer.


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Abstract
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Electronic supplementary material
About this article

A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo

Show Author's information Linping Fu1,2, Jianhu Zhang3, Chenchen Wu1,2, Weizhi Wang5, Dong Wang6( ), Zhiyuan Hu1,2,3,4( ), Zihua Wang1,3( )
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
School of Nanoscience and Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China
Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China
School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China
Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China

Abstract

Programmed death 1 (PD-1) and its ligand PD-L1 are two typical immune checkpoints. Antibody-based immune checkpoint blockade (ICB) strategy targeting PD-1/PD-L1 achieved a significant therapeutic effect on cancer. However, due to the impenetrability of antibody drugs and the occurrence of immune-related adverse events, only a minority of patients benefit from this treatment. Peptides multimerization has been widely proved to be an effective method to improve receptor binding affinity through a multivalent synergistic effect. In this study, we report a novel peptide-aggregation-induced emission (AIE) hybrid supramolecular TAP, which can self-assemble into nanofibers through non-covalent interactions such as hydrogen bonds, with a specific nanomolar affinity to PD-L1 in vivo and in vitro. Combined with near-infrared agents, it can be used for tumor imaging and photothermal therapy, which enables photothermal ablation of cancer cells for generating tumor-associated antigen (TAA) and triggering a series of immunological events. Collectively, our work suggests that synthetic self-assembled peptide nanofibers can be developed as attractive platforms for active photothermal immunotherapies against cancer.

Keywords: self-assembly, photothermal therapy, programmed death 1 (PD-1), targeting peptide, immune checkpoint blockade

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Publication history
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Acknowledgements

Publication history

Received: 23 January 2022
Revised: 16 March 2022
Accepted: 16 March 2022
Published: 26 April 2022
Issue date: August 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported financially by the National Natural Science Foundation of China (Nos. 32027801, 81801766, 21775031, and 31870992), the Strategic Priority Research Program of Chinese Academy of Sciences (Nos. XDB36000000 and XDB38010400), Foundation of Chongqing Municipal Education Commission (No. HZ2021006), CAS-JSPS (No. GJHZ2094), Fujian Medical University Foundation for the Introduction of Talents (Nos. XRCZX2017020, XRCZX2019005, and XRCZX2019018), and the Joint Funds for the innovation of science and Technology Fujian Province (No. 2019Y9001).

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