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Nano Research 2022, 15(8): 7533-7541 https://doi.org/10.1007/s12274-022-4324-4
Research Article | Issue | Published: 02 June 2022

Upconversion nanorods anchored metal-organic frameworks via hierarchical and dynamic assembly for synergistic therapy

Show Author's Information Wenfeng Guo§,  Li-Li Tan§( ),  Qiang Li,  Juanmin Li,  Li Shang( )
State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Chongqing Science and Technology Innovation Center, Northwestern Polytechnical University, Xi’an 710072, China

§ Wenfeng Guo and Li-Li Tan contributed equally to this work.

Keywords:
therapy, metal-organic frameworks, assembly, upconversion nanorods, heterogeneous nanomaterials
Topics:
Organic frameworks
Cite this article:
Guo W, Tan L-L, Li Q, et al. Upconversion nanorods anchored metal-organic frameworks via hierarchical and dynamic assembly for synergistic therapy. Nano Research, 2022, 15(8): 7533-7541. https://doi.org/10.1007/s12274-022-4324-4
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Abstract Full text Electronic supplementary material About this article

Heterogeneous materials made of metal-organic frameworks (MOFs) and optically active nanomaterials have attracted intensive interests in recent years due to their distinct physicochemical properties, but controllable fabrication of these materials remains challenging yet. In this work, we report a new strategy to in situ fabricate heterogeneous nanomaterials based on UiO-66-NH2 and upconversion nanorods (UCNRs) via a hierarchical and dynamic assembly process. Core–satellite structured UiO-66-NH2@UCNRs have been successfully fabricated, and the formation mechanism was thoroughly investigated by the combined use of scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Our results revealed the involvement of three main stages: supramolecular assembly of UiO-66-NH2 precursors with UCNRs, nucleation and growth of UiO-66-NH2 crystal, and dynamic assembly with UCNRs accompanied by Ostwald ripening. Furthermore, based on the hereditary optical and porous features of the heterogeneous nanomaterials, an enhanced multimodal synergistic anticancer platform has been established by integrating near-infrared (NIR)-triggered photodynamic therapy (PDT) and pH-triggered anticancer drug delivery, as confirmed by cellular experiments. The present study provides a new avenue for developing advanced functional heterogeneous nanomaterials via the hierarchical and dynamic assembly strategy.


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Electronic supplementary material
About this article

Upconversion nanorods anchored metal-organic frameworks via hierarchical and dynamic assembly for synergistic therapy

Show Author's information Wenfeng Guo§, Li-Li Tan§( ), Qiang Li, Juanmin Li, Li Shang( )
State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Chongqing Science and Technology Innovation Center, Northwestern Polytechnical University, Xi’an 710072, China

§ Wenfeng Guo and Li-Li Tan contributed equally to this work.

Abstract

Heterogeneous materials made of metal-organic frameworks (MOFs) and optically active nanomaterials have attracted intensive interests in recent years due to their distinct physicochemical properties, but controllable fabrication of these materials remains challenging yet. In this work, we report a new strategy to in situ fabricate heterogeneous nanomaterials based on UiO-66-NH2 and upconversion nanorods (UCNRs) via a hierarchical and dynamic assembly process. Core–satellite structured UiO-66-NH2@UCNRs have been successfully fabricated, and the formation mechanism was thoroughly investigated by the combined use of scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Our results revealed the involvement of three main stages: supramolecular assembly of UiO-66-NH2 precursors with UCNRs, nucleation and growth of UiO-66-NH2 crystal, and dynamic assembly with UCNRs accompanied by Ostwald ripening. Furthermore, based on the hereditary optical and porous features of the heterogeneous nanomaterials, an enhanced multimodal synergistic anticancer platform has been established by integrating near-infrared (NIR)-triggered photodynamic therapy (PDT) and pH-triggered anticancer drug delivery, as confirmed by cellular experiments. The present study provides a new avenue for developing advanced functional heterogeneous nanomaterials via the hierarchical and dynamic assembly strategy.

Keywords: therapy, metal-organic frameworks, assembly, upconversion nanorods, heterogeneous nanomaterials

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Publication history
Copyright
Acknowledgements

Publication history

Received: 01 March 2022
Revised: 13 March 2022
Accepted: 13 March 2022
Published: 02 June 2022
Issue date: August 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. U213010103 and 51821091), the Natural Science Foundation of Chongqing (No. cstc2020jcyj-msxmX1053), and the Fundamental Research Funds for the Central Universities (Nos. 3102019JC and 31020180QD085). We thank Prof. Ruichan Lv at Xidian University for upconversion luminescence measurement.

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