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Nano Research 2022, 15(7): 6297-6305 https://doi.org/10.1007/s12274-022-4240-7
Research Article | Issue | Published: 08 April 2022

Yellow responsive material based modification to reduce earphone induced Infection and hearing loss

Show Author's Information Haoxin Cheng1,2,  Hongmei Liu2,3,  Zhiqiang Liu1,2,  Ziying Xu4,  Xiaorong Liu1,2,  Shuang Jia2,  Chaonan He2,  Shichen Liu2,5,  Jiao Zhang2,  Xiaolei Wang1,2( )
College of Chemistry, Nanchang University, Nanchang 330088, China
The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330088, China
The First Clinical Medical School, Nanchang University, Nanchang 330088, China
The Stomatological School, Nanchang University, Nanchang 330088, China
The Department of Vascular Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang 330006, China
Keywords:
antibacterial activity, ZnO, earphone, yellow light, hearing loss
Topics:
Biomaterials
Cite this article:
Cheng H, Liu H, Liu Z, et al. Yellow responsive material based modification to reduce earphone induced Infection and hearing loss. Nano Research, 2022, 15(7): 6297-6305. https://doi.org/10.1007/s12274-022-4240-7
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Abstract Full text Electronic supplementary material About this article

Today, earphones have almost been owned by everyone. However, wearing earphones for a long time can cause two serious problems: (1) irreversible damage to hearing; (2) rapid proliferation of bacteria in the ear canal. Herein, an earphone modification strategy is developed for the first time, to reduce hearing loss and inhibit bacteria simultaneously. This earphone is equipped with a high purity yellow light (YL) light-emitting diode chip developed by our university. Then, the surface of the earphone is loaded with porous zinc oxide and silver nanoparticle composite material (ZnO-Ag) that can respond to the YL. Under the excitation of YL, the porous ZnO-Ag can release reactive oxygen species with strong antibacterial activity. More importantly, we discover that YL can reduce the expression of matrix metalloproteinase-3, the secretion of inflammatory factors, and apoptosis in the cochlea, thereby effectively reduce hearing loss.


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Abstract
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Electronic supplementary material
About this article

Yellow responsive material based modification to reduce earphone induced Infection and hearing loss

Show Author's information Haoxin Cheng1,2, Hongmei Liu2,3, Zhiqiang Liu1,2, Ziying Xu4, Xiaorong Liu1,2, Shuang Jia2, Chaonan He2, Shichen Liu2,5, Jiao Zhang2, Xiaolei Wang1,2( )
College of Chemistry, Nanchang University, Nanchang 330088, China
The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330088, China
The First Clinical Medical School, Nanchang University, Nanchang 330088, China
The Stomatological School, Nanchang University, Nanchang 330088, China
The Department of Vascular Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang 330006, China

Abstract

Today, earphones have almost been owned by everyone. However, wearing earphones for a long time can cause two serious problems: (1) irreversible damage to hearing; (2) rapid proliferation of bacteria in the ear canal. Herein, an earphone modification strategy is developed for the first time, to reduce hearing loss and inhibit bacteria simultaneously. This earphone is equipped with a high purity yellow light (YL) light-emitting diode chip developed by our university. Then, the surface of the earphone is loaded with porous zinc oxide and silver nanoparticle composite material (ZnO-Ag) that can respond to the YL. Under the excitation of YL, the porous ZnO-Ag can release reactive oxygen species with strong antibacterial activity. More importantly, we discover that YL can reduce the expression of matrix metalloproteinase-3, the secretion of inflammatory factors, and apoptosis in the cochlea, thereby effectively reduce hearing loss.

Keywords: antibacterial activity, ZnO, earphone, yellow light, hearing loss

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Publication history
Copyright
Acknowledgements

Publication history

Received: 07 January 2022
Revised: 13 February 2022
Accepted: 14 February 2022
Published: 08 April 2022
Issue date: July 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was funded by the National Natural Science Foundation of China (No. 31860263), Key Youth Project of Jiangxi Province (No. 20202ACB216002).

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