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Nano Research 2022, 15(7): 6288-6296 https://doi.org/10.1007/s12274-022-4239-0
Research Article | Issue | Published: 02 April 2022

NIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics

Show Author's Information Mingjian Ling1,2,§,  Rui Sun1,§,  Guang Li3,  Madiha Zahra Syeda4,  Wen Ma1,  Ziyi Mai1,  Longquan Shao2( ),  Longguang Tang5( ),  Zhiqiang Yu1( )
School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510632, China
Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510632, China
Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China
The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicin, Jinhua 322000, China

§ Mingjian Ling and Rui Sun contributed equally to this work.

Keywords:
theranostics, photothermal therapy, near-infrared (NIR-II) imaging, oral cancer, epithelial growth factor receptor (EGFR)
Topics:
Theranostics
Cite this article:
Ling M, Sun R, Li G, et al. NIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics. Nano Research, 2022, 15(7): 6288-6296. https://doi.org/10.1007/s12274-022-4239-0
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Abstract Full text Electronic supplementary material About this article

Oral cancer is a common malignant tumor of the head and neck, and surgery combined with radiotherapy and chemotherapy is the primary treatment modality. However, a positive resection margin that may lead to recurrence after surgery has always been a critical issue to address. Furthermore, radiotherapy and chemotherapy also have shortcomings such as resistance to chemotherapy and radiation, lack of targeting, and severe side effects. Therefore, exploring new methods of tumor surgical navigation and tumor treatment is of great significance for oral cancer. Although, the emerging near-infrared II (NIR-II, 1,000–1,700 nm) region fluorescent imaging has revolutionized surgical navigation, a high tumor-targeting fluorescent probe remains lacking. Furthermore, while emerging photothermal therapy (PTT) can overcome chemoradiotherapy’s shortcomings and achieve precise treatment of tumors, its clinical application is still limited by the lack of high photothermal conversion efficiency, high photothermal stability, and highly penetrating materials. Herein, a NIR-II dye SQ890 is developed for tumor imaging and PTT of oral cancer. By assembling into nanoparticles (NPs) and being modified with epithelial growth factor receptor (EGFR)-targeting peptides GE11, SQ890 NPs-Pep can specifically accumulate in tumor sites via active targeting, and realize photoacoustic/NIR-II fluorescence dual-modality imaging-guided PTT of oral cancer.


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Electronic supplementary material
About this article

NIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics

Show Author's information Mingjian Ling1,2,§, Rui Sun1,§, Guang Li3, Madiha Zahra Syeda4, Wen Ma1, Ziyi Mai1, Longquan Shao2( ), Longguang Tang5( ), Zhiqiang Yu1( )
School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510632, China
Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510632, China
Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China
The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicin, Jinhua 322000, China

§ Mingjian Ling and Rui Sun contributed equally to this work.

Abstract

Oral cancer is a common malignant tumor of the head and neck, and surgery combined with radiotherapy and chemotherapy is the primary treatment modality. However, a positive resection margin that may lead to recurrence after surgery has always been a critical issue to address. Furthermore, radiotherapy and chemotherapy also have shortcomings such as resistance to chemotherapy and radiation, lack of targeting, and severe side effects. Therefore, exploring new methods of tumor surgical navigation and tumor treatment is of great significance for oral cancer. Although, the emerging near-infrared II (NIR-II, 1,000–1,700 nm) region fluorescent imaging has revolutionized surgical navigation, a high tumor-targeting fluorescent probe remains lacking. Furthermore, while emerging photothermal therapy (PTT) can overcome chemoradiotherapy’s shortcomings and achieve precise treatment of tumors, its clinical application is still limited by the lack of high photothermal conversion efficiency, high photothermal stability, and highly penetrating materials. Herein, a NIR-II dye SQ890 is developed for tumor imaging and PTT of oral cancer. By assembling into nanoparticles (NPs) and being modified with epithelial growth factor receptor (EGFR)-targeting peptides GE11, SQ890 NPs-Pep can specifically accumulate in tumor sites via active targeting, and realize photoacoustic/NIR-II fluorescence dual-modality imaging-guided PTT of oral cancer.

Keywords: theranostics, photothermal therapy, near-infrared (NIR-II) imaging, oral cancer, epithelial growth factor receptor (EGFR)

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Publication history
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Acknowledgements

Publication history

Received: 05 January 2022
Revised: 08 February 2022
Accepted: 13 February 2022
Published: 02 April 2022
Issue date: July 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81773642 and 52073139), by the Postdoctoral Research Foundation of China (Nos. 2020TQ0253 and 2020M682927).

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