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Nano Research 2022, 15(7): 6266-6277 https://doi.org/10.1007/s12274-022-4236-3
Research Article | Issue | Published: 29 March 2022

Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) for solar dermatitis

Show Author's Information Jialing Yao1,3,  Junfeng Hui1,3( ),  Jing Yang1,3,  Jiaxin Yao1,3,  Chaoquan Hu2( ),  Daidi Fan1,3( )
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an 710069, China
Nanjing IPE Institute of Green Manufacturing Industry, Nanjing 211100, China
Biotech. & Biomed. Research Institute, Northwest University, Xi’an 710069, China
Keywords:
enzyme-catalyzed, semi-inter penetrating polymer network (Semi-IPN), sprayable hydrogel, nanodrug-loaded, solar dermatitis
Topics:
Controlled drug delivery
Cite this article:
Yao J, Hui J, Yang J, et al. Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) for solar dermatitis. Nano Research, 2022, 15(7): 6266-6277. https://doi.org/10.1007/s12274-022-4236-3
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Abstract Full text Electronic supplementary material About this article

Solar dermatitis is an acute or chronic high incidence of skin injury caused by ultraviolet (UV) radiation based on strong sunlight, which seriously endangers people's health. In this study, we designed and demonstrated enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) sprayable nanodrug-loaded hydrogels based on gelatin, 3-(4-hydroxyphenyl) propionic acid (HPA), polyvinyl alcohol (PVA), glycerol, and dexamethasone sodium phosphate (DEXP) for solar dermatitis. The hydrogels had high water content, excellent biocompatibility, effective encapsulation and sustained release of nanodrugs, anti-inflammatory, and strong anti-ultraviolet B (anti-UVB) radiation properties based on glycerol and phenol functional groups, but also controllable spray gelation mode to make them adhere well on the dynamic skin surfaces and achieve continuous transdermal drugs delivery for solar dermatitis. The sprayable nanodrug-loaded hydrogel systems could be used as a highly effective therapeutic method for solar dermatitis, and also provide a good strategy for designing novel nanodrug-loaded hydrogel delivery systems.


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About this article

Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) for solar dermatitis

Show Author's information Jialing Yao1,3, Junfeng Hui1,3( ), Jing Yang1,3, Jiaxin Yao1,3, Chaoquan Hu2( ), Daidi Fan1,3( )
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an 710069, China
Nanjing IPE Institute of Green Manufacturing Industry, Nanjing 211100, China
Biotech. & Biomed. Research Institute, Northwest University, Xi’an 710069, China

Abstract

Solar dermatitis is an acute or chronic high incidence of skin injury caused by ultraviolet (UV) radiation based on strong sunlight, which seriously endangers people's health. In this study, we designed and demonstrated enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) sprayable nanodrug-loaded hydrogels based on gelatin, 3-(4-hydroxyphenyl) propionic acid (HPA), polyvinyl alcohol (PVA), glycerol, and dexamethasone sodium phosphate (DEXP) for solar dermatitis. The hydrogels had high water content, excellent biocompatibility, effective encapsulation and sustained release of nanodrugs, anti-inflammatory, and strong anti-ultraviolet B (anti-UVB) radiation properties based on glycerol and phenol functional groups, but also controllable spray gelation mode to make them adhere well on the dynamic skin surfaces and achieve continuous transdermal drugs delivery for solar dermatitis. The sprayable nanodrug-loaded hydrogel systems could be used as a highly effective therapeutic method for solar dermatitis, and also provide a good strategy for designing novel nanodrug-loaded hydrogel delivery systems.

Keywords: enzyme-catalyzed, semi-inter penetrating polymer network (Semi-IPN), sprayable hydrogel, nanodrug-loaded, solar dermatitis

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Publication history
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Acknowledgements

Publication history

Received: 29 January 2022
Revised: 11 February 2022
Accepted: 13 February 2022
Published: 29 March 2022
Issue date: July 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 22078265, 22108225, and 21838009), the Shaanxi Provincial Science Foundation (Nos. 2017SF-201 and 2021JQ-434), and China Postdoctoral Science Foundation (No. 2018M643720).

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