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Nano Research 2022, 15(5): 4224-4232 https://doi.org/10.1007/s12274-021-4039-y
Research Article | Issue | Published: 18 January 2022

Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

Show Author's Information Lishan Zhang1,2,§,  Ting Yin1,2,§,  Baozhen Zhang2,§,  Chong Yan1,  Chengyu Lu1,  Lanlan Liu2,  Ze Chen2,  Hui Ran1,2,  Qingxia Shi1,2,  Hong Pan2( ),  Aiqing Ma1,2( ),  Lintao Cai2( )
Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory for Nanomedicine, Guangdong Medical University, Dongguan 523808, China
Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China

§ Lishan Zhang, Ting Yin, and Baozhen Zhang contributed equally to this work.

Keywords:
biomimetic materials, sonodynamic therapy, hybrid cell membrane, photochlor sonosensitizer, noninvasive treatment
Topics:
Biomaterials
Cite this article:
Zhang L, Yin T, Zhang B, et al. Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer. Nano Research, 2022, 15(5): 4224-4232. https://doi.org/10.1007/s12274-021-4039-y
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Abstract Full text Electronic supplementary material About this article

Sonodynamic therapy (SDT) has aroused considerable momentum in cancer therapy due to its abilities of deep penetration, low toxicity, and noninvasion, while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT effect. Here, we developed a 4T1 cancer cell-macrophage hybrid membrane (HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor (HPPH)-loaded albumin nanoparticles (PHNPs). The experimental results proved that the HM-coated biomimetic NPs (PHNPs@HM) could express the characteristic membrane proteins of both cancer cells and macrophages, remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune escaping. Meanwhile, as a novel sonosensitizer, HPPH could generate amount of reactive oxygen species (ROS) under ultrasound (US) irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell apoptosis. This study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency.


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About this article

Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

Show Author's information Lishan Zhang1,2,§, Ting Yin1,2,§, Baozhen Zhang2,§, Chong Yan1, Chengyu Lu1, Lanlan Liu2, Ze Chen2, Hui Ran1,2, Qingxia Shi1,2, Hong Pan2( ), Aiqing Ma1,2( ), Lintao Cai2( )
Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory for Nanomedicine, Guangdong Medical University, Dongguan 523808, China
Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China

§ Lishan Zhang, Ting Yin, and Baozhen Zhang contributed equally to this work.

Abstract

Sonodynamic therapy (SDT) has aroused considerable momentum in cancer therapy due to its abilities of deep penetration, low toxicity, and noninvasion, while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT effect. Here, we developed a 4T1 cancer cell-macrophage hybrid membrane (HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor (HPPH)-loaded albumin nanoparticles (PHNPs). The experimental results proved that the HM-coated biomimetic NPs (PHNPs@HM) could express the characteristic membrane proteins of both cancer cells and macrophages, remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune escaping. Meanwhile, as a novel sonosensitizer, HPPH could generate amount of reactive oxygen species (ROS) under ultrasound (US) irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell apoptosis. This study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency.

Keywords: biomimetic materials, sonodynamic therapy, hybrid cell membrane, photochlor sonosensitizer, noninvasive treatment

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Publication history
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Acknowledgements

Publication history

Received: 11 October 2021
Revised: 30 November 2021
Accepted: 02 December 2021
Published: 18 January 2022
Issue date: May 2022

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81901864, 81971749, and 82072064), the Natural Science Foundation of Guangdong Province (Nos. 2021A1515010131 and 2019A1515011524), Guangdong Province Universities and Colleges Pearl River Scholar Fund (No. 4SG21006G), Shenzhen Science and Technology Program (Nos. JCYJ20170818162259843 and JCYJ20210324115607020), Guangdong Province Universities and Colleges Characteristic Innovation (Nos. 2021KTSCX035 and 2021KTSCX036), Special Funds of Scientific Technological Innovation of Undergraduates in Guangdong Province (Nos. pdjh2020b0260 and pdjh2020b0265), Guangdong Medical University PHD Funds (2021), Medical Scientific Research Foundation of Guangdong Province (No. A2021429), and Zhuhai Innovation and Entrepreneurship Team Project (No. ZH01110405180056PWC).

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