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Nano Research 2022, 15(5): 4175-4180 https://doi.org/10.1007/s12274-021-4004-9
Research Article | Issue | Published: 14 December 2021

A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses

Show Author's Information Xinpei Li1,2,  Xiaofeng He1,2,  Dongrong He1,2,  Yuan Liu1,2,  Kun Chen1,2( ),  Panchao Yin1,2( )
South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou 510640, China
Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, China
Keywords:
immune response, vaccine adjuvant, co-assembly, metal oxide cluster, supramolecular interaction
Topics:
Vaccines
Cite this article:
Li X, He X, He D, et al. A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses. Nano Research, 2022, 15(5): 4175-4180. https://doi.org/10.1007/s12274-021-4004-9
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Abstract Full text Electronic supplementary material About this article

Long-lasting protective immune responses are expected following vaccination. However, most vaccines alone are inability to evoke an efficient protection. The combinatory administration of adjuvants with vaccines is critical for generating the enhanced immune responses. Herein, with biocompatible poly(4-vinylpyridine) (P4VP) as template, 2.5 nm iron/molybdenum oxide cluster, {Mo72Fe30}, is applied as an adjuvant to co-assemble with antigens of Mycobacterium bovis via hydrogen bonding at molecular scale. Molecular scale integration of the antigens and {Mo72Fe30} and their full exposure to body fluid media contribute to the augmentation of both humoral and cellular immune responses of the vaccines after inoculation in mice. Anti-inflammatory factor IL-10 gradually increases after 2 weeks followed by a final back to normal level by the 5th week. The balance between proinflammatory cytokines and anti-inflammatory factors suggests that immune system can be activated in the early stage of infection by the antigens carried by the supra-particles and secrete acute inflammatory factors for host defense and anti-inflammatory factors for immune protection.


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Electronic supplementary material
About this article

A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses

Show Author's information Xinpei Li1,2, Xiaofeng He1,2, Dongrong He1,2, Yuan Liu1,2, Kun Chen1,2( ), Panchao Yin1,2( )
South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou 510640, China
Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510640, China

Abstract

Long-lasting protective immune responses are expected following vaccination. However, most vaccines alone are inability to evoke an efficient protection. The combinatory administration of adjuvants with vaccines is critical for generating the enhanced immune responses. Herein, with biocompatible poly(4-vinylpyridine) (P4VP) as template, 2.5 nm iron/molybdenum oxide cluster, {Mo72Fe30}, is applied as an adjuvant to co-assemble with antigens of Mycobacterium bovis via hydrogen bonding at molecular scale. Molecular scale integration of the antigens and {Mo72Fe30} and their full exposure to body fluid media contribute to the augmentation of both humoral and cellular immune responses of the vaccines after inoculation in mice. Anti-inflammatory factor IL-10 gradually increases after 2 weeks followed by a final back to normal level by the 5th week. The balance between proinflammatory cytokines and anti-inflammatory factors suggests that immune system can be activated in the early stage of infection by the antigens carried by the supra-particles and secrete acute inflammatory factors for host defense and anti-inflammatory factors for immune protection.

Keywords: immune response, vaccine adjuvant, co-assembly, metal oxide cluster, supramolecular interaction

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Publication history
Copyright
Acknowledgements

Publication history

Received: 21 October 2021
Revised: 16 November 2021
Accepted: 17 November 2021
Published: 14 December 2021
Issue date: May 2022

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

The work was supported financially by the National Natural Science Foundation of China (Nos. 22101086, 21961142018, and 51873067) and the Natural Science Foundation of Guangdong Province (Nos. 2021A1515012024 and 2021A1515010271).

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