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Nano Research 2022, 15(5): 4154-4163 https://doi.org/10.1007/s12274-021-3997-4
Research Article | Issue | Published: 15 January 2022

Mesoporous radiosensitized nanoprobe for enhanced NIR-II photoacoustic imaging-guided accurate radio-chemotherapy

Show Author's Information Tao Chen1,  Lichao Su1,  Lisen Lin1,  Xiaoguang Ge1,  Feicheng Bai1,  Meng Niu1,  Chenlu Wang1,  Jibin Song1,  Shaolei Guo2( ),  Huanghao Yang1( )
MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, China
Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
Keywords:
photocatalysis, tumor hypoxia, photoacoustic imaging, radiotherapy, second near infrared window (NIR-II)
Topics:
Nanoparticles
Cite this article:
Chen T, Su L, Lin L, et al. Mesoporous radiosensitized nanoprobe for enhanced NIR-II photoacoustic imaging-guided accurate radio-chemotherapy. Nano Research, 2022, 15(5): 4154-4163. https://doi.org/10.1007/s12274-021-3997-4
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Abstract Full text Electronic supplementary material About this article

Oxygen deficiency is a major obstacle to hypoxic-related cancer theranostics, and developing the oxygen production nanoplatforms received the widespread attention. However, it is remaining a challenge to structure a nanoplatform with hypoxia alleviation effect and imaging-guided cancer radiotherapy. Herein, we present a novel theranostics nanoplatform (Au NPs/UCNPs/WO3@C) comprising of tungsten trioxide (WO3) that loaded gold nanoparticles (Au NPs) and up-conversion nanoparticles (UCNPs) for improved photoacoustic (PA) imaging performance in the second near infrared window (NIR-II, 900–1,700 nm). Au NPs/UCNPs/WO3@C exhibited superior oxygen-generation effect and doxorubicin loading capacity, thus serving as an efficient radiosensitizer for radio-chemo anti-cancer therapy. Importantly, the accumulated Au NPs/UCNPs/WO3@C in the tumor region led to the increased NIR-II PA imaging signal and the blood oxygen saturation signal, which could enhance radiation sensitivity and accurately guiding cancer radiotherapy to reduce side effects on normal tissues. This study with proof-of-concept confirmed the multifaceted characteristics and encouraging potential of biomimetic Au NPs/UCNPs/WO3@C for NIR-II PA imaging-guided tumor therapeutics.


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Electronic supplementary material
About this article

Mesoporous radiosensitized nanoprobe for enhanced NIR-II photoacoustic imaging-guided accurate radio-chemotherapy

Show Author's information Tao Chen1, Lichao Su1, Lisen Lin1, Xiaoguang Ge1, Feicheng Bai1, Meng Niu1, Chenlu Wang1, Jibin Song1, Shaolei Guo2( ), Huanghao Yang1( )
MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, China
Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China

Abstract

Oxygen deficiency is a major obstacle to hypoxic-related cancer theranostics, and developing the oxygen production nanoplatforms received the widespread attention. However, it is remaining a challenge to structure a nanoplatform with hypoxia alleviation effect and imaging-guided cancer radiotherapy. Herein, we present a novel theranostics nanoplatform (Au NPs/UCNPs/WO3@C) comprising of tungsten trioxide (WO3) that loaded gold nanoparticles (Au NPs) and up-conversion nanoparticles (UCNPs) for improved photoacoustic (PA) imaging performance in the second near infrared window (NIR-II, 900–1,700 nm). Au NPs/UCNPs/WO3@C exhibited superior oxygen-generation effect and doxorubicin loading capacity, thus serving as an efficient radiosensitizer for radio-chemo anti-cancer therapy. Importantly, the accumulated Au NPs/UCNPs/WO3@C in the tumor region led to the increased NIR-II PA imaging signal and the blood oxygen saturation signal, which could enhance radiation sensitivity and accurately guiding cancer radiotherapy to reduce side effects on normal tissues. This study with proof-of-concept confirmed the multifaceted characteristics and encouraging potential of biomimetic Au NPs/UCNPs/WO3@C for NIR-II PA imaging-guided tumor therapeutics.

Keywords: photocatalysis, tumor hypoxia, photoacoustic imaging, radiotherapy, second near infrared window (NIR-II)

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Publication history
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Acknowledgements

Publication history

Received: 05 September 2021
Revised: 12 November 2021
Accepted: 14 November 2021
Published: 15 January 2022
Issue date: May 2022

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

This research was supported by the National Natural Science Foundation of China (Nos. 22027805 and 21874024), the National Key R&D Program of China (No. 2020YFA0210800), the joint research projects of Health and Education Commission of Fujian Province (No. 2019-WJ-20), and the Natural Science Foundation of Fujian Province (No. 2020J02012).

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