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Nano Research 2022, 15(4): 3504-3513 https://doi.org/10.1007/s12274-021-3869-y
Mini Review | Issue | Published: 04 December 2021

Engineering DNA quadruplexes in DNA nanostructures for biosensor construction

Show Author's Information Jingxin Liu1,§,  Li Yan1,§,  Shiliang He1( ),  Junqing Hu1,2( )
College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China
Shenzhen Bey Laboratory, Shenzhen 518132, China

§ Jingxin Liu and Li Yan contributed equally to this work.

Keywords:
DNA nanotechnology, biosensor, G-quadruplex, i-motif
Topics:
Nano detection
Cite this article:
Liu J, Yan L, He S, et al. Engineering DNA quadruplexes in DNA nanostructures for biosensor construction. Nano Research, 2022, 15(4): 3504-3513. https://doi.org/10.1007/s12274-021-3869-y
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Abstract Full text About this article

DNA quadruplexes are nucleic acid conformations comprised of four strands. They are prevalent in human genomes and increasing efforts are being directed toward their engineering. Taking advantage of the programmability of Watson–Crick base-pairing and conjugation methodology of DNA with other molecules, DNA nanostructures of increasing complexity and diversified geometries have been artificially constructed since 1980s. In this review, we investigate the interweaving of natural DNA quadruplexes and artificial DNA nanostructures in the development of the ever-prosperous field of biosensing, highlighting their specific roles in the construction of biosensor, including recognition probe, signal probe, signal amplifier and support platform. Their implementation in various sensing scenes was surveyed. And finally, general conclusion and future perspective are discussed for further developments.


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About this article

Engineering DNA quadruplexes in DNA nanostructures for biosensor construction

Show Author's information Jingxin Liu1,§, Li Yan1,§, Shiliang He1( ), Junqing Hu1,2( )
College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China
Shenzhen Bey Laboratory, Shenzhen 518132, China

§ Jingxin Liu and Li Yan contributed equally to this work.

Abstract

DNA quadruplexes are nucleic acid conformations comprised of four strands. They are prevalent in human genomes and increasing efforts are being directed toward their engineering. Taking advantage of the programmability of Watson–Crick base-pairing and conjugation methodology of DNA with other molecules, DNA nanostructures of increasing complexity and diversified geometries have been artificially constructed since 1980s. In this review, we investigate the interweaving of natural DNA quadruplexes and artificial DNA nanostructures in the development of the ever-prosperous field of biosensing, highlighting their specific roles in the construction of biosensor, including recognition probe, signal probe, signal amplifier and support platform. Their implementation in various sensing scenes was surveyed. And finally, general conclusion and future perspective are discussed for further developments.

Keywords: DNA nanotechnology, biosensor, G-quadruplex, i-motif

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Publication history
Copyright
Acknowledgements

Publication history

Received: 16 July 2021
Revised: 28 August 2021
Accepted: 04 September 2021
Published: 04 December 2021
Issue date: April 2022

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 51972055, 81803480, and 21902101), the Shenzhen Science and Technology Research Project (No. JCYJ20180508152903208), the Shenzhen Pengcheng Scholar Program, and Shenzhen Bay Laboratory Open Fund (No. SZBL2020090501002).

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