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Research Article

Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy

Jinghan Wang1,2, Shanqing Gao1, Xiao Wang3, Haozhen Zhang1, Xitong Ren1, Juewen Liu2( ), Feng Bai1( )
Key Laboratory for Special Functional Materials of Ministry of Education, National & Local Joint Engineering Research Center for High efficiency Display and Lighting Technology, School of Materials Science and Engineering, and Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng 475004, China
Department of Chemistry, Waterloo Institute for Nanotechnology, Waterloo, Ontario N2L 3G1, Canada
Henan and Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng 475004, China
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Graphical Abstract

Abstract

The use of functional nanoparticles as peroxidase-like (POD-like) catalyst has recently become a focus of research in cancer therapy. Phthalocyanine is a macrocyclic conjugated metal ligand, which is expected to achieve a high POD-like catalytic activity, generating free radicals and inhibiting the proliferation of cancer cells. In this paper, we synthesized phthalocyanine nanocrystals with different structures through noncovalent self-assembly confined within micro-emulsion droplets, and manganese phthalocyanine (MnPc) possessing a metal–N–C active center was used as the building block. These nano-assemblies exhibit shape-dependent POD-like catalytic activities, because the emulsifier and MnPc co-mixed assembly reduced the close packing between MnPc molecules and exposed more active sites. The assembly had a water-dispersed nanostructure, which is conducive to accumulation at tumor sites through the enhanced permeability and retention effect (EPR). Because of a highly efficient microenvironmental response, the assembly showed higher catalytic activity only emerged under the acidic tumor-like microenvironment, but caused less damage to normal tissues in biomedical applications. In vivo and in vitro catalytic therapy tests showed excellent anti-tumor effects. This work explored a new way for the application of metal–organic macromolecules such as MnPc as nanozymes for catalytic tumor therapy.

Keywords

self-assemblymanganese phthalocyaninenanozymesperoxidasecatalytic therapy

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Nano Research
Volume 15 Issue 3,
March 2022
Pages 2347-2354
DOI: 10.1007/s12274-021-3854-5
Cite this article:
Wang J, Gao S, Wang X, et al. Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy. Nano Research, 2022, 15(3): 2347-2354. https://doi.org/10.1007/s12274-021-3854-5
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Received: 23 July 2021
Revised: 21 August 2021
Accepted: 29 August 2021
Published: 29 September 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021
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