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Nano Research 2022, 15(2): 1554-1563 https://doi.org/10.1007/s12274-021-3701-8
Research Article | Issue | Published: 11 August 2021

Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy

Show Author's Information Hui Ding1,3,  Daji Wang1,3,  Haibing Huang1,  Xiaozhu Chen1,  Jie Wang1,  Jinjie Sun1,  Jianlin Zhang2,  Lu Lu1,  Beiping Miao1,  Yanjuan Cai1,  Kelong Fan3,  Yongtian Lu1,  Hongsong Dong1,  Xiyun Yan3( ),  Guohui Nie1( ),  Minmin Liang2( )
Shenzhen Key Laboratory of Nanozymes and Translational Cancer Research, Department of OtolaryngologyInstitute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen518035China
Experimental Center of Advanced MaterialsSchool of Materials Science and Engineering, Beijing Institute of TechnologyBeijing100081China
Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of Biophysics, Chinese Academy of SciencesBeijing100101China
Keywords:
nanozymes, black phosphorus quantum dots, glucose oxidase-like activity, photothermal/catalytic synergistic therapy
Topics:
Biomaterials
An erratum to this article is available online at https://doi.org/10.1007/s12274-022-5087-7
Cite this article:
Ding H, Wang D, Huang H, et al. Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy. Nano Research, 2022, 15(2): 1554-1563. https://doi.org/10.1007/s12274-021-3701-8
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Abstract Full text Electronic supplementary material About this article

Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability, easy preparation, and tunable catalytic properties, especially in the field of cancer therapy. However, the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications. Herein, we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots (BPQDs) nanozymes that simultaneously exhibited an exceptional near-infrared (NIR) photothermal property and dramatically photothermal-enhanced glucose oxidase (GOx)-like activity in the acidic tumor microenvironment. We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9% that could rapidly heat the tumor up to 50 ℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection. Meanwhile, the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose. By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity, the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo. We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy.


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Electronic supplementary material
About this article

Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy

Show Author's information Hui Ding1,3, Daji Wang1,3, Haibing Huang1, Xiaozhu Chen1, Jie Wang1, Jinjie Sun1, Jianlin Zhang2, Lu Lu1, Beiping Miao1, Yanjuan Cai1, Kelong Fan3, Yongtian Lu1, Hongsong Dong1, Xiyun Yan3( ), Guohui Nie1( ), Minmin Liang2( )
Shenzhen Key Laboratory of Nanozymes and Translational Cancer Research, Department of OtolaryngologyInstitute of Translational Medicine, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen518035China
Experimental Center of Advanced MaterialsSchool of Materials Science and Engineering, Beijing Institute of TechnologyBeijing100081China
Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of Biophysics, Chinese Academy of SciencesBeijing100101China

Abstract

Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability, easy preparation, and tunable catalytic properties, especially in the field of cancer therapy. However, the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications. Herein, we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots (BPQDs) nanozymes that simultaneously exhibited an exceptional near-infrared (NIR) photothermal property and dramatically photothermal-enhanced glucose oxidase (GOx)-like activity in the acidic tumor microenvironment. We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9% that could rapidly heat the tumor up to 50 ℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection. Meanwhile, the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose. By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity, the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo. We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy.

Keywords: nanozymes, black phosphorus quantum dots, glucose oxidase-like activity, photothermal/catalytic synergistic therapy

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Publication history
Copyright
Acknowledgements

Publication history

Received: 26 March 2021
Revised: 10 June 2021
Accepted: 20 June 2021
Published: 11 August 2021
Issue date: February 2022

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

This work was supported by the National Key Research and Development Program of China (Nos. 2020YFC1316900 and 2020YFC1316901), China Postdoctoral Science Foundation (Nos. 2019T120754 and 2018M633229), Sanming Project of Medicine in Shenzhen (No. SZSM201612031), National Natural Science Foundation of China (Nos. 82003303 and 81722024), National Key R & D Program of China (No. 2017YFA0205501), Natural Science Foundation of Guangdong Province of China (Nos. 2018A030310665 and 2018A0303130295), Shenzhen Science and Technology Innovation Committee (Nos. JSGG20191129144225464, JCYJ20190806163814395, ZDSYS201707281114196, JCYJ20170306091657539, JCYJ20170413162242627, JCYJ20170306091452714, and GJHZ20170313172439851), Development and Reform Commission of Shenzhen Municipality (No. S2016005470013). The animal study protocol was approved by the Institutional Animal Care and Use Committee at Shenzhen University.

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