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Nano Research 2021, 14(11): 4264-4273 https://doi.org/10.1007/s12274-021-3624-4
Research Article | Issue | Published: 23 July 2021

Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery

Show Author's Information Zhongyin Chen1,§,  Tao Liao1,§,  Lihui Wan1,  Ying Kuang2,  Chang Liu1,  Junlin Duan1,  Xiangyu Xu1,  Ziqiang Xu1( ),  Bingbing Jiang1,  Cao Li1( )
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei Key Laboratory of Polymer Materials Hubei University Wuhan 430062 China
Glyn O. Philips Hydrocolloid Research Centre at HUT Hubei University of Technology Wuhan 430068 China

§ Zhongyin Chen and Tao Liao contributed equally to this work.

Keywords:
charge-reversal, hollow mesoporous silica nanoparticles, near-infrared emissive carbon dots, dual-stimuli responsive
Topics:
Nanodots
An erratum to this article is available online at https://doi.org/10.1007/s12274-021-3765-5
Cite this article:
Chen Z, Liao T, Wan L, et al. Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery. Nano Research, 2021, 14(11): 4264-4273. https://doi.org/10.1007/s12274-021-3624-4
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Abstract Full text Electronic supplementary material About this article

Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue.


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Electronic supplementary material
About this article

Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery

Show Author's information Zhongyin Chen1,§, Tao Liao1,§, Lihui Wan1, Ying Kuang2, Chang Liu1, Junlin Duan1, Xiangyu Xu1, Ziqiang Xu1( ), Bingbing Jiang1, Cao Li1( )
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei Key Laboratory of Polymer Materials Hubei University Wuhan 430062 China
Glyn O. Philips Hydrocolloid Research Centre at HUT Hubei University of Technology Wuhan 430068 China

§ Zhongyin Chen and Tao Liao contributed equally to this work.

Abstract

Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue.

Keywords: charge-reversal, hollow mesoporous silica nanoparticles, near-infrared emissive carbon dots, dual-stimuli responsive

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Publication history
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Acknowledgements

Publication history

Received: 06 April 2021
Revised: 24 May 2021
Accepted: 26 May 2021
Published: 23 July 2021
Issue date: November 2021

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

This study was funded by National Natural Science Foundation of China (Nos. 51773055, 51973053, and 22073025) and Natural Science Foundation of Hubei Province of China (No. 2019CFB748).

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