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Nano Research 2022, 15(1): 71-84 https://doi.org/10.1007/s12274-021-3483-z
Review Article | Issue | Published: 19 April 2021

Nucleobase, nucleoside, nucleotide, and oligonucleotide coordinated metal ions for sensing and biomedicine applications

Show Author's Information Jiaojiao Zhou1,2,  Heyou Han1( ),  Juewen Liu2( )
State Key Laboratory of Agricultural MicrobiologyCollege of Food Science and Technology, Huazhong Agricultural UniversityWuhan430070China
Department of ChemistryWaterloo Institute for Nanotechnology, University of WaterlooWaterlooON N2L 3G1Canada
Keywords:
self-assembly, nanostructures, metal ions, DNA, nucleotides
Topics:
Theranostics
Cite this article:
Zhou J, Han H, Liu J. Nucleobase, nucleoside, nucleotide, and oligonucleotide coordinated metal ions for sensing and biomedicine applications. Nano Research, 2022, 15(1): 71-84. https://doi.org/10.1007/s12274-021-3483-z
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Abstract Full text About this article

Metal ions play critical roles in chemical, biological, and environmental processes. Various biomolecules have the ability to coordinate with metal ions and form various materials. Nucleobases, nucleosides, and nucleotides, as the essential components of DNA, have emerged as a useful building block for the construction of functional nanomaterials. In recent years, DNA oligonucleotides have also been used for this purpose. We herein review the strategies for the synthesis of soft nanomaterials through the assembly of nucleotides (or DNA) and metal ions to yield various nanoparticles, fibers, and hydrogels. Such coordination methods are simple to operate and can be carried out under ambient conditions. The luminescent, catalytic, and molecular recognition properties of these coordination materials are described with representative recent examples. Their applications ranging from biosensing, enzyme encapsulation, catalysis, templated shell growth to cancer therapy are highlighted. Finally, challenges of this field and future perspectives are discussed.


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About this article

Nucleobase, nucleoside, nucleotide, and oligonucleotide coordinated metal ions for sensing and biomedicine applications

Show Author's information Jiaojiao Zhou1,2, Heyou Han1( ), Juewen Liu2( )
State Key Laboratory of Agricultural MicrobiologyCollege of Food Science and Technology, Huazhong Agricultural UniversityWuhan430070China
Department of ChemistryWaterloo Institute for Nanotechnology, University of WaterlooWaterlooON N2L 3G1Canada

Abstract

Metal ions play critical roles in chemical, biological, and environmental processes. Various biomolecules have the ability to coordinate with metal ions and form various materials. Nucleobases, nucleosides, and nucleotides, as the essential components of DNA, have emerged as a useful building block for the construction of functional nanomaterials. In recent years, DNA oligonucleotides have also been used for this purpose. We herein review the strategies for the synthesis of soft nanomaterials through the assembly of nucleotides (or DNA) and metal ions to yield various nanoparticles, fibers, and hydrogels. Such coordination methods are simple to operate and can be carried out under ambient conditions. The luminescent, catalytic, and molecular recognition properties of these coordination materials are described with representative recent examples. Their applications ranging from biosensing, enzyme encapsulation, catalysis, templated shell growth to cancer therapy are highlighted. Finally, challenges of this field and future perspectives are discussed.

Keywords: self-assembly, nanostructures, metal ions, DNA, nucleotides

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Publication history
Copyright
Acknowledgements

Publication history

Received: 06 February 2021
Revised: 13 March 2021
Accepted: 15 March 2021
Published: 19 April 2021
Issue date: January 2022

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

We gratefully appreciate the support from Natural Sciences and Engineering Research Council of Canada (NSERC), and National Natural Science Foundation of China (No. 21778020). Zhou J. was supported by the HZAU overseas Academic Fund to visit the University of Waterloo.

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