Journal Home > Volume 14 , Issue 11

Infectious diseases caused by bacteria are a global threat to the human health. Here, we propose a solvent "irrigation" technique to endow TiO2 nanotubes (NTs) to precisely modify with functional nanomaterials, and apply them in constructing a near-infrared (NIR) light controlled drug-delivery system for rapid necrosis of bacteria. In this design, the NIR stimuli-responsive functional shell is located on the external tube wall of TiO2 NT; the internal tube wall offers sufficient binding sites for drug loading. Using kanamycin as a model drug, we demonstrate that the reactive oxygen species generated in photocatalysis not only controllably release the loaded drug by scissoring the linked chains, but also effectively compromise bacteria membrane integrity by damaging the cell wall. Benefiting from the damages, antibiotics rapidly enter the bacteria and reach ≥99.9% reduction in Escherichia coli colony within only 2 h. Importantly, such a covalently conjugation-based delivery system can efficiently relieve radical-induced inflammation and cytotoxicity. This study provides an innovative design strategy for engineering delivery systems with tailorable components, enduring stimuli-response by multiple triggers.

File
12274_2021_3338_MOESM1_ESM.pdf (3.2 MB)
Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 24 November 2020
Revised: 12 January 2021
Accepted: 15 January 2021
Published: 10 February 2021
Issue date: November 2021

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021

Acknowledgements

Acknowledgements

This research is supported by the National Natural Science Foundation of China (Nos. 21874013, 22074013, and 21775016) and the Research Funds for the Central Universities (Nos. N182410008-1 and N2005027), and the Talent Project of Revi- talizing Liaoning (No. XLYC1807165). Special thanks are due to the instrumental or data analysis from Analytical and Testing Center, Northeastern University.

Rights and permissions

Reprints and Permission requests may be sought directly from editorial office.
Email: nanores@tup.tsinghua.edu.cn

Return