AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Research Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article

Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Zhicheng Zhang1, Yawen Ding1, Jinbiao Li1, Li Wang1, Xiaoyan Xin2( ), Jing Yan3( ), Jinhui Wu1, Ahu Yuan1, Yiqiao Hu1( )
State Key Laboratory of Pharmaceutical Biotechnology, Medical School /School of Life Sciences, Nanjing University, Nanjing 210093, China
Department of Radiology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Medical School/Clinical Cancer Institute, Nanjing University, Nanjing 210093, China
Show Author Information

Abstract

Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.

Graphical Abstract

Keywords

ferroptosisvitamin K3 derivativenanoscale coordination polymerglutathione peroxidase attenuationiron pool increasehydrogen peroxide generation

Electronic Supplementary Material

Download File(s)
12274_2020_3241_MOESM1_ESM.pdf (1.7 MB)

References

【1】
【1】
 
 
Crossref Google Scholar
Nano Research
Volume 14 Issue 7,
July 2021
Pages 2398-2409
DOI: 10.1007/s12274-020-3241-7

{{item.num}}

Comments on this article

Go to comment

< Back to all reports

Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

Review Comment

Cite this Report
Close
Close
Cite this article:
Zhang Z, Ding Y, Li J, et al. Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy. Nano Research, 2021, 14(7): 2398-2409. https://doi.org/10.1007/s12274-020-3241-7
Topics:
Cell death NanoparticlesTumors

1825

Views

19

Crossref

0

Web of Science

18

Scopus

0

CSCD
Received: 11 September 2020
Revised: 08 November 2020
Accepted: 14 November 2020
Published: 05 July 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020