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Research Article

Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Zhicheng Zhang1, Yawen Ding1, Jinbiao Li1, Li Wang1, Xiaoyan Xin2( ), Jing Yan3( ), Jinhui Wu1, Ahu Yuan1, Yiqiao Hu1( )
State Key Laboratory of Pharmaceutical Biotechnology, Medical School /School of Life Sciences, Nanjing University, Nanjing 210093, China
Department of Radiology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Medical School/Clinical Cancer Institute, Nanjing University, Nanjing 210093, China
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Abstract

Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.

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Keywords

ferroptosisvitamin K3 derivativenanoscale coordination polymerglutathione peroxidase attenuationiron pool increasehydrogen peroxide generation

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Nano Research
Volume 14 Issue 7,
July 2021
Pages 2398-2409
DOI: 10.1007/s12274-020-3241-7

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Cite this article:
Zhang Z, Ding Y, Li J, et al. Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy. Nano Research, 2021, 14(7): 2398-2409. https://doi.org/10.1007/s12274-020-3241-7
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Cell death NanoparticlesTumors

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Received: 11 September 2020
Revised: 08 November 2020
Accepted: 14 November 2020
Published: 05 July 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020