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Research Article

Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymium-doped gadolinium tungstate nanoparticles

Xujiang Yu1,2,§,  Aodenggerile2,§, Zhao Jiang3, Jianliang Shen4,5, Zhiqiang Yan1( ), Wanwan Li3( ), Huibin Qiu2( )
Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China

§ Xujiang Yu and Aodenggerile contribute equally to this work.

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Abstract

Second near-infrared (NIR-II) fluorescence imaging is a recently emerged technique and is highly useful for accurate diagnosis of cancer. Although a diverse array of fluorescent nanomaterials have been developed to enable NIR-II fluorescence in various situations, they normally fail to unify the clinical techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI). Therefore, exploiting multimodal agents to integrate the newly emerged NIR-II fluorescence and traditional clinical techniques would be of key significance. Here, we report a rational fabrication of neodymium (Nd)-doped gadolinium tungstate nanoparticles (NPs) that are subsequentially decorated with a hydrophilic layer and demonstrate that they can achieve the harmonious integration of NIR-II fluorescence imaging, CT, and MRI. The NIR-II fluorescence emission was activated by an incident light with discrete wavelength ranging from 250 to 810 nm. NIR-II fluorescence-CT-MRI associated trimodal imaging was subsequently demonstrated for breast cancer by an 808 nm laser, along with the estimation of NIR-II fluorescence imaging for cervical cancer. The integration of newly emerged and traditional clinical imaging techniques highlights the huge potential of rare-earth-doped NPs for multimodal imaging of different types of cancer.

Keywords

cancermultimodal imagingrare-earth-doped nanoparticles (NPs)second near-infrared fluorescence

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References

[1]
Luciani, S.; Cabanes, A.; Prieto-Lara, E.; Gawryszewski, V. Cervical and female breast cancers in the Americas: Current situation and opportunities for action. Bull. World Health Organ. 2013, 91, 640-649.
Google Scholar
[2]
Ginsburg, O.; Bray, F.; Coleman, M. P.; Vanderpuye, V.; Eniu, A.; Kotha, S. R.; Sarker, M.; Huong, T. T.; Allemani, C.; Dvaladze, A. et al. The global burden of women’s cancers: A grand challenge in global health. Lancet 2017, 389, 847-860.
Google Scholar
[3]
Torre, L. A.; Islami, F.; Siegel, R. L.; Ward, E. M.; Jemal, A. Global cancer in women: Burden and trends. Cancer Epidemiol. Biomarkers Prev. 2017, 26, 444-457.
Google Scholar
[4]
Tsu, V. D.; Jeronimo, J.; Anderson, B. O. Why the time is right to tackle breast and cervical cancer in low-resource settings. Bull. World Health Organ. 2013, 91, 683-690.
Google Scholar
[5]
Liu, M. H.; Guo, H. B.; Liu, H. B.; Zhang, Z. Y.; Chi, C. W.; Hui, H.; Dong, D.; Hu, Z. H.; Tian, J. In vivo pentamodal tomographic imaging for small animals. Biomed. Opt. Express 2017, 8, 1356-1371.
Google Scholar
[6]
Goel, S.; Ferreira, C. A.; Chen, F.; Ellison, P. A.; Siamof, C. M.; Barnhart, T. E.; Cai, W. B. Activatable hybrid nanotheranostics for tetramodal imaging and synergistic photothermal/photodynamic therapy. Adv. Mater. 2018, 30, 1704367.
Google Scholar
[7]
Rieffel, J.; Chen, F.; Kim, J.; Chen, G. Y.; Shao, W.; Shao, S.; Chitgupi, U.; Hernandez, R.; Graves, S. A.; Nickles, R. J. et al. Hexamodal imaging with porphyrin-phospholipid-coated upconversion nanoparticles. Adv. Mater. 2015, 27, 1785-1790.
Google Scholar
[8]
Miranda, D.; Carter, K.; Luo, D. D.; Shao, S.; Geng, J. M.; Li, C. N.; Chitgupi, U.; Turowski, S. G.; Li, N. S.; Atilla-Gokcumen, E. A. et al. Multifunctional liposomes for image-guided intratumoral chemo- phototherapy. Adv. Healthc. Mater. 2017, 6, 1700253.
Google Scholar
[9]
Grodzinski, P.; Kircher, M.; Goldberg, M.; Gabizon, A. Integrating nanotechnology into cancer care. ACS Nano 2019, 13, 7370-7376.
Google Scholar
[10]
Lusic, H.; Grinstaff, M. W. X-ray-computed tomography contrast agents. Chem. Rev. 2013, 113, 1641-1666.
Google Scholar
[11]
Lee, N.; Yoo, D.; Ling, D. S.; Cho, M. H.; Hyeon, T.; Cheon, J. Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy. Chem. Rev. 2015, 115, 10637-10689.
Google Scholar
[12]
Yankeelov, T. E.; Mankoff, D. A.; Schwartz, L. H.; Lieberman, F. S.; Buatti, J. M.; Mountz, J. M.; Erickson, B. J.; Fennessy, F. M. M.; Huang, W.; Kalpathy-Cramer, J. et al. Quantitative imaging in cancer clinical trials. Clin. Cancer Res. 2016, 22, 284-290.
Google Scholar
[13]
O’Connor, J. P. B.; Aboagye, E. O.; Adams, J. E.; Aerts, H. J. W. L.; Barrington, S. F.; Beer, A. J.; Boellaard, R.; Bohndiek, S. E.; Brady, M.; Brown, G. et al. Imaging biomarker roadmap for cancer studies. Nat. Rev. Clin. Oncol. 2017, 14, 169-186.
Google Scholar
[14]
Yu, X. J.; Li, A.; Zhao, C. Z.; Yang, K.; Chen, X. Y.; Li, W. W. Ultrasmall semimetal nanoparticles of bismuth for dual-modal computed tomography/photoacoustic imaging and synergistic thermoradiotherapy. ACS Nano 2017, 11, 3990-4001.
Google Scholar
[15]
Frangioni, J. V. New technologies for human cancer imaging. J. Clin. Oncol. 2018, 26, 4012-4021.
Google Scholar
[16]
Smith, A. M.; Mancini, M. C.; Nie, S. M. Second window for in vivo imaging. Nat. Nanotechnol. 2019, 4, 710-711.
Google Scholar
[17]
Welsher, K.; Liu, Z.; Sherlock, S. P.; Robinson, J.; Chen, Z.; Daranciang, D.; Dai, H. J. A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice. Nat. Nanotechnol. 2009, 4, 773-780.
Google Scholar
[18]
Sun, C. X.; Li, B. H.; Zhao, M. Y.; Wang, S. F.; Lei, Z. H.; Lu, L. F.; Zhang, H. X.; Feng, L. S.; Dou, C. R.; Yin, D. R. et al. J-aggregates of cyanine dye for NIR-II in vivo dynamic vascular imaging beyond 1500 nm. J. Am. Chem. Soc. 2019, 141, 19221-19225.
Google Scholar
[19]
Kang, Y. W.; Yu, X. J.; Fan, X. Y.; Aodenggerile, Zhao, S. Z.; Tu, C. L.; Yan, Z. Q.; Wang, R. B.; Li, W. W.; Qiu, H. B. Tetramodal imaging and synergistic cancer radio-chemotherapy enabled by multiple component-encapsulated zeolitic imidazolate frameworks. ACS Nano 2020, 14, 4336-4351.
Google Scholar
[20]
Jiang, Y. Y.; Upputuri, P. K.; Xie, C.; Zeng, Z. L.; Sharma, A.; Zhen, X.; Li, J. C.; Huang, J. G.; Pramanik, M.; Pu, K. Y. Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging. Adv. Mater. 2019, 31, 1808166.
Google Scholar
[21]
He, S. Q.; Song, J.; Qu, J. L.; Cheng, Z. Crucial breakthrough of second near-infrared biological window fluorophores: Design and synthesis toward multimodal imaging and theranostics. Chem. Soc. Rev. 2018, 47, 4258-4278.
Google Scholar
[22]
Kantamneni, H.; Zevon, M.; Donzanti, M. J.; Zhao, X. Y.; Sheng, Y.; Barkund, S. R.; McCabe, L. H.; Banach-Petrosky, W.; Higgins, L. M.; Ganesan, S. et al. Surveillance nanotechnology for multi-organ cancer metastases. Nat. Biomed. Eng. 2017, 1, 993-1003.
Google Scholar
[23]
Gong, H.; Peng, R.; Liu, Z. Carbon nanotubes for biomedical imaging: The recent advances. Adv. Drug Deliv. Rev. 2013, 65, 1951-1963.
Google Scholar
[24]
Hong, G. S.; Diao, S.; Chang, J. L.; Antaris, A. L.; Chen, C. X.; Zhang, B.; Zhao, S.; Atochin, D. N.; Huang, P. L.; Andreasson, K. I. et al. Through-skull fluorescence imaging of the brain in a new near-infrared window. Nat. Photonics 2014, 8, 723-730.
Google Scholar
[25]
Hong, G. S.; Robinson, J. T.; Zhang, Y. J.; Diao, S.; Antaris, A. L.; Wang, Q. B.; Dai, H. J. In vivo fluorescence imaging with Ag2S quantum dots in the second near-infrared region. Angew. Chem., Int. Ed. 2012, 51, 9818-9821.
Google Scholar
[26]
Zhang, M. X.; Yue, J. Y.; Cui, R.; Ma, Z. R.; Wan, H.; Wang, F. F.; Zhu, S. J.; Zhou, Y.; Kuang, Y.; Zhong, Y. T. et al. Bright quantum dots emitting at ~ 1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging. Proc. Natl. Acad. Sci. USA 2018, 115, 6590-6595.
Google Scholar
[27]
Yang, T.; Tang, Y. A.; Liu, L.; Lv, X. Y.; Wang, Q. L.; Ke, H. T.; Deng, Y. B.; Yang, H.; Yang, X. L.; Liu, G. et al. Size-dependent Ag2S nanodots for second near-infrared fluorescence/photoacoustics imaging and simultaneous photothermal therapy. ACS Nano 2017, 11, 1848-1857.
Google Scholar
[28]
Zhu, S. J.; Tian, R.; Antaris, A. L.; Chen, X. Y.; Dai, H. J. Near-infrared-II molecular dyes for cancer imaging and surgery. Adv. Mater. 2019, 31, 1900321.
Google Scholar
[29]
Li, B. H.; Lu, L. F.; Zhao, M. Y.; Lei, Z. H.; Zhang, F. An efficient 1064 nm NIR-II excitation fluorescent molecular dye for deep-tissue high-resolution dynamic bioimaging. Angew. Chem., Int. Ed. 2018, 57, 7483-7487.
Google Scholar
[30]
Antaris, A. L.; Chen, H.; Cheng, K.; Sun, Y.; Hong, G. S.; Qu, C. R.; Diao, S.; Deng, Z. X.; Hu, X. M.; Zhang, B. et al. A small-molecule dye for NIR-II imaging. Nat. Mater. 2016, 15, 235-242.
Google Scholar
[31]
Chen, C.; Ni, X.; Jia, S.; Liang, Y.; Wu, X.; Kong, D.; Ding, D. Massively evoking immunogenic cell death by focused mitochondrial oxidative stress using an AIE luminogen with a twisted molecular structure. Adv. Mater. 2019, 31, 1904914.
Google Scholar
[32]
Chen, C.; Ou, H.; Liu, R.; Ding, D. Regulating the photophysical property of organic/polymer optical agents for promoted cancer phototheranostics. Adv. Mater. 2020, 32, 1806331.
Google Scholar
[33]
Ni, X.; Zhang, X.; Duan, X.; Zheng, H. L.; Xue, X. S.; Ding, D. Near-infrared afterglow luminescent aggregation-Induced emission dots with ultrahigh tumor-to-liver signal ratio for promoted image- guided cancer surgery. Nano Lett. 2019, 19, 318-330.
Google Scholar
[34]
Guo, B.; Chen, J. Q.; Chen, N. B.; Middha, E.; Xu, S. D.; Pan, Y. T.; Wu, M.; Li, K.; Liu, C. B.; Liu, B. High-resolution 3D NIR-II photoacoustic imaging of cerebral and tumor vasculatures using conjugated polymer nanoparticles as contrast agent. Adv. Mater. 2019, 31, 1808355.
Google Scholar
[35]
Hong, G. S.; Zou, Y. P.; Antaris, A. L.; Diao, S.; Wu, D.; Cheng, K.; Zhang, X. D.; Chen, C. X.; Liu, B.; He, Y. H. et al. Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window. Nat. Commun. 2014, 5, 4206.
Google Scholar
[36]
Zhang, H. X.; Fan, Y.; Pei, P.; Sun, C. X.; Lu, L. F.; Zhang, F. Tm3+- sensitized NIR-II fluorescent nanocrystals for in vivo information storage and decoding. Angew. Chem., Int. Ed. 2019, 58, 10153-10157.
Google Scholar
[37]
Wang, S. F.; Liu, L.; Fan, Y.; El-Toni, A. M.; Alhoshan, M. S.; Li, D. D.; Zhang, F. In vivo high-resolution ratiometric fluorescence imaging of inflammation using NIR-II nanoprobes with 1550 nm emission. Nano Lett. 2019, 19, 2418-2427.
Google Scholar
[38]
Naczynski, D. J.; Tan, M. C.; Zevon, M.; Wall, B.; Kohl, J.; Kulesa, A.; Chen, S.; Roth, C. M.; Riman, R. E.; Moghe, P. V. Rare-earth-doped biological composites as in vivo shortwave infrared reporters. Nat. Commun. 2013, 4, 2199.
Google Scholar
[39]
Chen, G. Y.; Ohulchanskyy, T. Y.; Liu, S.; Law, W. C.; Wu, F.; Swihart, M. T.; Ågren, H.; Prasad, P. N. Core/shell NaGdF4: Nd3+/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications. ACS Nano 2012, 6, 2969-2977.
Google Scholar
[40]
Lammers, T.; Ferrari, M. The success of nanomedicine. Nano Today 2020, 31, 100853.
Google Scholar
[41]
D’Mello, S. R.; Cruz, C. N.; Chen, M. L.; Kapoor, M.; Lee, S. L.; Tyner, K. M. The evolving landscape of drug products containing nanomaterials in the United States. Nat. Nanotechnol. 2017, 12, 523-529.
Google Scholar
[42]
Bobo, D.; Robinson, K. J.; Islam, J.; Thurecht, K. J.; Corrie, S. R. Nanoparticle-based medicines: A review of FDA-approved materials and clinical trials to date. Pharm. Res. 2016, 33, 2373-2387.
Google Scholar
[43]
Bonvalot, S.; Rutkowski, P. L.; Thariat, J.; Carrère, S.; Ducassou, A.; Sunyach, M. P.; Agoston, P.; Hong, A.; Mervoyer, A.; Rastrelli, M. et al. NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): A multicentre, phase 2-3, randomised, controlled trial. Lancet Oncol. 2019, 20, 1148-1159.
Google Scholar
[44]
Wang, R.; Li, X. M.; Zhou, L.; Zhang, F. Epitaxial seeded growth of rare-earth nanocrystals with efficient 800 nm near-infrared to 1525 nm short-wavelength infrared downconversion photoluminescence for in vivo bioimaging. Angew. Chem., Int. Ed. 2014, 53, 12086-12090.
Google Scholar
[45]
Naczynski, D. J.; Sun, C.; Türkcan, S.; Jenkins, C.; Koh, A. L.; Ikeda, D.; Pratx, G.; Xing, L. X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes. Nano Lett. 2015, 15, 96-102.
Google Scholar
[46]
Dang, X. N.; Gu, L.; Qi, J. F.; Correa, S.; Zhang, G. R.; Belcher, A. M.; Hammond, P. T. Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer. Proc. Natl. Acad. Sci. USA 2016, 113, 5179-5184.
Google Scholar
[47]
Zhong, Y. T.; Ma, Z. R.; Zhu, S. J.; Yue, J. Y.; Zhang, M. X.; Antaris, A. L.; Yuan, J.; Cui, R.; Wan, H.; Zhou, Y. et al. Boosting the down- shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm. Nat. Commun. 2017, 8, 737.
Google Scholar
[48]
Ding, F.; Zhan, Y. B.; Lu, X. J.; Sun, Y. Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging. Chem. Sci. 2018, 9, 4370-4380.
Google Scholar
[49]
Yu, X. J.; Liu, X. Y.; Wu, W. J.; Yang, K.; Mao, R. H.; Ahmad, F.; Chen, X. Y.; Li, W. W. CT/MRI-guided synergistic radiotherapy and X-ray inducible photodynamic therapy using Tb-doped Gd-W- nanoscintillators. Angew. Chem., Int. Ed. 2019, 58, 2017-2022.
Google Scholar
[50]
Guo T.; Lin, Y.; Zhang, W. J.; Hong, J. S.; Lin, R. H.; Wu, X. P.; Li, J.; Lu, C. H.; Yang, H. H. High-efficiency X-ray luminescence in Eu3+-activated tungstate nanoprobes for optical imaging through energy transfer sensitization. Nanoscale 2018, 10, 1607-1612.
Google Scholar
[51]
Hudson, D. E.; Hudson, D. O.; Wininger, J. M.; Richardson, B. D. Penetration of laser light at 808 and 980 nm in bovine tissue samples. Photomed. Laser Surg. 2013, 31, 163-168.
Google Scholar
[52]
Lyu, Y.; Xie, C.; Chechetka, S. A.; Miyako, E.; Pu, K. Y. Semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons. J. Am. Chem. Soc. 2016, 138, 9049-9052.
Google Scholar
[53]
Zhong, Y. T.; Tian, G.; Gu, Z. J.; Yang, Y. J.; Gu, L.; Zhao, Y. L.; Ma, Y.; Yao, J. N. Elimination of photon quenching by a transition layer to fabricate a quenching-shield sandwich structure for 800 nm excited upconversion luminescence of Nd3+-sensitized nanoparticles. Adv. Mater. 2014, 26, 2831-2837.
Google Scholar
[54]
Kotagiri, N.; Sudlow, G. P.; Akers, W. J.; Achilefu, S. Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers. Nat. Nanotechnol. 2015, 10, 370-379.
Google Scholar
[55]
Chen, Q.; Wu, J.; Ou, X.; Huang, B.; Almutlaq, J.; Zhumekenov, A.; Guan, X.; Han, S.; Liang, L.; Yi, Z. et. al. All-inorganic perovskite nanocrystal scintillators. Nature 2018, 561, 88-93.
Google Scholar
[56]
Nashed, R.; Alamgir, F. M.; Jang, S. S.; Ismail, Y.; El-Sayed, M. A.; Allam, N. K. Bandgap bowing in Ta-W-O system for efficient solar energy conversion: Insights from density functional theory and X-ray diffraction. Appl. Phys. Lett. 2013, 103, 133905.
Google Scholar
[57]
Ye, S.; Song, E. H.; Zhang, Q. Y. Transition metal-involved photon upconversion. Adv. Sci. 2016, 3, 1600302.
Google Scholar
[58]
Pernodet, N.; Fang, X. H.; Sun, Y.; Bakhtina, A.; Ramakrishnan, A.; Sokolov, J.; Ulman, A.; Rafailovich, M. Adverse effects of citrate/ gold nanoparticles on human dermal fibroblasts. Small 2006, 2, 766-773.
Google Scholar
[59]
Li, M. H.; Sun, X. T.; Zhang, N.; Wang, W.; Yang, Y.; Jia, H. Z.; Liu, W. G. NIR-activated polydopamine-coated carrier-free “nanobomb” for in situ on-demand drug release. Adv. Sci. 2018, 5, 1800155.
Google Scholar
[60]
Zhou, J. J.; Xiong, Q. R.; Ma, J. L.; Ren, J. H.; Messersmith, P. B.; Chen, P.; Duan, H. W. Polydopamine-enabled approach toward tailored plasmonic nanogapped nanoparticles: From nanogap engineering to multifunctionality. ACS Nano 2016, 10, 11066-11075.
Google Scholar
[61]
Choi, C. K. K.; Chiu, Y. T. E.; Zhuo, X. L.; Liu, Y.; Pak, C. Y.; Liu, X. D.; Tse, Y. L. S.; Wang, J. F.; Choi, C. H. J. Dopamine-mediated assembly of citrate-capped plasmonic nanoparticles into stable core-shell nanoworms for intracellular applications. ACS Nano 2019, 13, 5864-5884.
Google Scholar
[62]
Swierczewska, M.; Cho, K. Y.; Mertz, E. L.; Huang, X. L.; Zhang, F.; Zhu, L.; Yoon, H. Y.; Park, J. H.; Bhirde, A.; Lee, S. et al. A facile, one-step nanocarbon functionalization for biomedical applications. Nano Lett. 2012, 12, 3613-3620.
Google Scholar
[63]
Zhou, J.; Li, M. H.; Hou, Y. H.; Luo, Z.; Chen, Q. F.; Cao, H. X.; Huo, R. L.; Xue, C. C.; Sutrisno, L.; Hao, L. et al. Engineering of a nanosized biocatalyst for combined tumor starvation and low- temperature photothermal therapy. ACS Nano 2018, 12, 2858-2872.
Google Scholar
[64]
Kim, S.; Jang, Y.; Jang, L. K.; Sunwoo, S. H.; Kim, T. I.; Cho, S. W.; Lee, J. Y. Electrochemical deposition of dopamine-hyaluronic acid conjugates for anti-biofouling bioelectrodes. J. Mater. Chem. B 2017, 5, 4507-4513.
Google Scholar
[65]
Nyk, M.; Kumar, R.; Ohulchanskyy, T. Y.; Bergey, E. J.; Prasad, P. N. High contrast in vitro and in vivo photoluminescence bioimaging using near infrared to near infrared up-conversion in Tm3+ and Yb3+ doped fluoride nanophosphors. Nano Lett. 2008, 8, 3834-3838.
Google Scholar
[66]
Rocha, U.; Kumar, K. U.; Jacinto, C.; Villa, I.; Sanz-Rodríguez, F.; del Carmen Iglesias de la Cruz M.; Juarranz, A.; Carrasco, E.; van Veggel, F. C. J. M.; Bovero, E.; Solé, J. G. et al. Neodymium-doped LaF3 nanoparticles for fluorescence bioimaging in the second biological window. Small 2014, 10, 1141-1154.
Google Scholar
[67]
Heffern, M. C.; Matosziuk, L. M.; Meade, T. J. Lanthanide probes for bioresponsive imaging. Chem. Rev. 2014, 114, 4496-4539.
Google Scholar
[68]
Kohane, D. S.; Langer, R. Biocompatibility and drug delivery systems. Chem. Sci. 2010, 1, 441-446.
Google Scholar
[69]
Rieffel, J.; Chitgupi, U.; Lovell, J. F. Recent advances in higher-order, multimodal, biomedical imaging agents. Small 2015, 11, 4445-4461.
Google Scholar
[70]
Hyafil, F.; Cornily, J. C.; Feig, J. E.; Gordon, R.; Vucic, E.; Amirbekian, V.; Fisher, E. A.; Fuster, V.; Feldman, L. J.; Fayad, Z. A. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat. Med. 2007, 13, 636-641.
Google Scholar
[71]
Cho, N. H.; Cheong, T. C.; Min, J. H.; Wu, J. H.; Lee, S. J.; Kim, D.; Yang, J. S.; Kim, S.; Kim, Y. K.; Seong, S. Y. A multifunctional core- shell nanoparticle for dendritic cell-based cancer immunotherapy. Nat. Nanotechnol. 2011, 6, 675-682.
Google Scholar
[72]
Wang, X.; Guo, Z.; Zhang, C. Y.; Zhu, S.; Li, L. L.; Gu, Z. J.; Zhao, Y. L. Ultrasmall BiOI quantum dots with efficient renal clearance for enhanced radiotherapy of cancer. Adv. Sci. 2020, 7, 1902561.
Google Scholar
[73]
Chen, X. F.; Song, J. B.; Chen, X. Y.; Yang, H. H. X-ray-activated nanosystems for theranostic applications. Chem. Soc. Rev. 2019, 48, 3073-3101.
Google Scholar
[74]
Ni, D. L.; Zhang, J. W.; Wang, J.; Hu, P.; Jin, Y. Y.; Tang, Z. M.; Yao, Z. W.; Bu, W. B.; Shi, J. L. Oxygen vacancy enables markedly enhanced magnetic resonance imaging-guided photothermal therapy of a Gd3+-doped contrast agent. ACS Nano 2017, 11, 4256-4264.
Google Scholar
Nano Research
Volume 14 Issue 7,
July 2021
Pages 2160-2170
DOI: 10.1007/s12274-020-3136-7
Cite this article:
Yu X, Aodenggerile, Jiang Z, et al. Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymium-doped gadolinium tungstate nanoparticles. Nano Research, 2021, 14(7): 2160-2170. https://doi.org/10.1007/s12274-020-3136-7
Topics:
DiseasesInfrared devices Magnetic resonance imagingMedical imagingNanoparticlesRare earthsTungsten compounds

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Received: 01 September 2020
Revised: 15 November 2020
Accepted: 24 November 2020
Published: 05 July 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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