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Nano Research 2021, 14(7): 2145-2153 https://doi.org/10.1007/s12274-020-3114-0
Research Article | Issue | Published: 05 July 2021

Mineralized manganese dioxide channel as the stent coating for in situ precise tumor navigation

Show Author's Information Junyuan Xiao1,2,§,  Yiran Zhang1,2,§,  Tonglei Fang1,  Tianwen Yuan4,  Qinghua Tian1,  Jingjing Liu1,  Yingsheng Cheng1( ),  Yueqi Zhu1( ),  Liang Cheng3( ),  Wenguo Cui2( )
Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yishan Road, Shanghai 200233, China
Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory of Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, China
Depatment of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai 200237, China

§ Junyuan Xiao and Yiran Zhang contributed equally to this work.

Keywords:
electrospinning, stent, photodynamic therapy, tumor hypoxia, manganese dioxide
Topics:
Coatings Controlled drug deliveryDiseasesElectrospinningManganese oxideTargeted drug deliveryTumors
An erratum to this article is available online at https://doi.org/10.1007/s12274-021-3299-x
Cite this article:
Xiao J, Zhang Y, Fang T, et al. Mineralized manganese dioxide channel as the stent coating for in situ precise tumor navigation. Nano Research, 2021, 14(7): 2145-2153. https://doi.org/10.1007/s12274-020-3114-0
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Abstract Full text Electronic supplementary material About this article

Drug-eluting stent (DES) is a promising strategy for esophageal cancer. However, full-covered drug-loaded stents cause damage to non-tumor tissue in the esophagus, and the development controlled-release system to prevent non-tumor tissue injure is currently a major challenge. Here, in situ mineralized manganese dioxide coating on Ce6 embedded electrospun fibers covered stent was developed for effective tumor therapy via intraluminal photodynamic therapy (PDT), which could reduce phototoxicity to normal esophageal tissue. Oxidation of manganese ions, which was previously swelled between fibers, was used to accomplish mineralization. After implantation, the manganese dioxide coating in situ reacts with tumor endogenous H+ and H2O2, which, on the one hand, could effectively alleviate the hypoxic microenvironment which leads to resistance to PDT, and on the other hand, could expose the Ce6-fibers below the coating for intraluminal PDT. In addition, due to the slow degradation of the coating, this stent could own sustained photodynamic performance for up to one month. Notably, the PDT efficiency of the stent was investigated on orthotopic rabbit esophageal cancer models. Overall, this work suggests that in situ mineralized manganese dioxide coated electrospun fibers covered stent may provide a new strategy for advanced esophageal cancer patients as a functional drug delivery platform.


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Abstract
Full text
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Electronic supplementary material
About this article

Mineralized manganese dioxide channel as the stent coating for in situ precise tumor navigation

Show Author's information Junyuan Xiao1,2,§, Yiran Zhang1,2,§, Tonglei Fang1, Tianwen Yuan4, Qinghua Tian1, Jingjing Liu1, Yingsheng Cheng1( ), Yueqi Zhu1( ), Liang Cheng3( ), Wenguo Cui2( )
Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yishan Road, Shanghai 200233, China
Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory of Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, China
Depatment of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai 200237, China

§ Junyuan Xiao and Yiran Zhang contributed equally to this work.

Abstract

Drug-eluting stent (DES) is a promising strategy for esophageal cancer. However, full-covered drug-loaded stents cause damage to non-tumor tissue in the esophagus, and the development controlled-release system to prevent non-tumor tissue injure is currently a major challenge. Here, in situ mineralized manganese dioxide coating on Ce6 embedded electrospun fibers covered stent was developed for effective tumor therapy via intraluminal photodynamic therapy (PDT), which could reduce phototoxicity to normal esophageal tissue. Oxidation of manganese ions, which was previously swelled between fibers, was used to accomplish mineralization. After implantation, the manganese dioxide coating in situ reacts with tumor endogenous H+ and H2O2, which, on the one hand, could effectively alleviate the hypoxic microenvironment which leads to resistance to PDT, and on the other hand, could expose the Ce6-fibers below the coating for intraluminal PDT. In addition, due to the slow degradation of the coating, this stent could own sustained photodynamic performance for up to one month. Notably, the PDT efficiency of the stent was investigated on orthotopic rabbit esophageal cancer models. Overall, this work suggests that in situ mineralized manganese dioxide coated electrospun fibers covered stent may provide a new strategy for advanced esophageal cancer patients as a functional drug delivery platform.

Keywords: electrospinning, stent, photodynamic therapy, tumor hypoxia, manganese dioxide

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Publication history
Copyright
Acknowledgements

Publication history

Received: 25 July 2020
Revised: 06 September 2020
Accepted: 12 September 2020
Published: 05 July 2021
Issue date: July 2021

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This research was funded by the National Natural Science Foundation of China (Nos. 81971714, 81771943, and 51873107), Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grants (Nos. 20152528 and 20171906), Shanghai Jiao Tong University "Medical and Research" Program (Nos. ZH2018ZDA04 and ZH2018ZDA19) and Shanghai Talent Development Fund (No. 2018099), and the Collaborative Innovation Center of Suzhou Nano Science and Technology. L. Cheng was supported by the Tang Scholar of Soochow University. The funding agencies had no role in the study design, execution or data interpretation. All animal experiments were carried out with permission by Soochow University Laboratory Animal Center.

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