AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Research Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article

Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors

Yinghua Zhang1,2,§, Huifang Liu2,3,§, Xinyue Dai1,2, Hang Li1,2, Xiaohan Zhou2, Shizhu Chen4,5, Jinchao Zhang1,2( ), Xing-Jie Liang2,3,6, Zhenhua Li1,2( )
College of Chemistry & Environmental Science, Analytical Chemistry Key Laboratory of Hebei Province, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China
College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China
Beijing Pharmaceutical Group Company Limited, Beijing 100101, China
The National Institutes of Pharmaceutical R&D Co., Ltd., China Resources Pharmaceutical Group Limited, Beijing 102206, China
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China

§ Yinghua Zhang and Huifang Liu contributed equally to this work.

Show Author Information

Graphical Abstract

Abstract

Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy, as well as predisposing for increased tumor metastases. Therefore, strategies for the eradication of the hypoxic tumor are highly desirable. Photodynamic therapy (PDT) is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer. Compared to traditional radiotherapy and chemotherapy, photodynamic therapy has many advantages, such as good selectivity, low toxicity, and less trauma and resistance. However, PDT is oxygen-dependent, and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective. Cyanobacteria, the earliest photosynthetic oxygen-generating organisms, can utilize water as an electron donor to reduce CO2 into organic carbon compounds along with continuously releasing oxygen under sunlight. Inspired by this, herein, cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles (UCNP) to construct a self-supplying oxygen PDT system. Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared (NIR) light using UCNP as a light harvesting antenna. A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.

Keywords

photodynamic therapyupconversion nanoparticlesself-supplying oxygencyanobacteriahypoxic tumor

Electronic Supplementary Material

Download File(s)
12274_2020_3094_MOESM1_ESM.pdf (4.3 MB)

References

[1]
G. L. Semenza, The hypoxic tumor microenvironment: A driving force for breast cancer progression. Biochim. Biophys. Acta 2016, 3, 382-391.
Crossref Google Scholar
[2]
L. B. Harrison,; M. Chadha,; R. J. Hill,; K. Hu,; D. Shasha, Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 2002, 7, 492-508.
Crossref Google Scholar
[3]
B. J. Cummings,; T. J. Keane,; B. O’Sullivan,; C. S. Wong,; C. N. Catton, Epidermoid anal cancer: Treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int. J. Radiat. Oncol. Biol. Phys. 1991, 21, 1115-1125.
Crossref Google Scholar
[4]
Z. Z. Chen,; M. Niu,; G. Chen,; Q. Wu,; L. F. Tan,; C. H. Fu,; X. L. Ren,; H. S. Zhong,; K. Xu,; X. W. Meng, Oxygen production of modified core-shell CuO@ZrO2 nanocomposites by microwave radiation to alleviate cancer hypoxia for enhanced chemo-microwave thermal therapy. ACS Nano 2018, 12, 12721-12732.
Crossref Google Scholar
[5]
C. R. Nishida,; M. Lee,; P. R. O. de Montellano, Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1. Mol. Pharmacol. 2010, 78, 497-502.
Crossref Google Scholar
[6]
S. B. Reddy,; S. K. Williamson, Tirapazamine: A novel agent targeting hypoxic tumor cells. Expert Opin. Investig. Drugs 2009, 18, 77-87.
Crossref Google Scholar
[7]
J. D. Sun,; Q. Liu,; J. L. Wang,; D. Ahluwalia,; D. Ferraro,; Y. Wang,; J. X. Duan,; W. S. Ammons,; J. G. Curd,; M. D. Matteucci, et al. Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin. Cancer Res. 2012, 18, 758-770.
Crossref Google Scholar
[8]
D. W. Felsher, Cancer revoked: Oncogenes as therapeutic targets. Nat. Rev. Cancer 2003, 3, 375-379.
Crossref Google Scholar
[9]
P. Agostinis,; K. Berg,; K. A. Cengel,; T. H. Foster,; A. W. Girotti,; S. O. Gollnick,; S. M. Hahn,; M. R. Hamblin,; A. Juzeniene,; D. Kessel, et al. Photodynamic therapy of cancer: An update. CA. Cancer J. Clin. 2011, 61, 250-281.
Crossref Google Scholar
[10]
J. M. Dąbrowski,; L. G. Arnaut, Photodynamic therapy (PDT) of cancer: From local to systemic treatment. Photochem. Photobiol. Sci. 2015, 14, 1765-1780.
Crossref Google Scholar
[11]
Y. H. Cheng,; H. Cheng,; C. X. Jiang,; X. F. Qiu,; K. K. Wang,; W. Huan,; A. H. Yuan,; J. H. Wu,; Y. Q. Hu, Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy. Nat. Commun. 2015, 6, 8785.
Crossref Google Scholar
[12]
W. W. Zhu,; Z. L. Dong,; T. T. Fu,; J. J. Liu,; Q. Chen,; Y. G. Li,; R. Zhu,; L. G. Xu,; Z. Liu, Modulation of hypoxia in solid tumor microenvironment with MnO2 nanoparticles to enhance photodynamic therapy. Adv. Funct. Mater. 2016, 26, 5490-5498.
Crossref Google Scholar
[13]
C. R. Gordijo,; A. Z. Abbasi,; M. A. Amini,; H. Y. Lip,; A. Maeda,; P. Cai,; P. J. O'Brien,; R. S. DaCosta,; A. M. Rauth,; X. Y. Wu, Design of hybrid MnO2-polymer-lipid nanoparticles with tunable oxygen generation rates and tumor accumulation for cancer treatment. Adv. Funct. Mater. 2015, 25, 1858-1872.
Crossref Google Scholar
[14]
Q. Chen,; L. Z. Feng,; J. J. Liu,; W. W. Zhu,; Z. L. Dong,; Y. F. Wu,; Z. Liu, Intelligent albumin-MnO2 nanoparticles as pH-/H2O2- responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy. Adv. Mater. 2016, 28, 7129-7136.
Crossref Google Scholar
[15]
H. Cheng,; J. Y. Zhu,; S. Y. Li,; J. Y. Zeng,; Q. Lei,; K. W. Chen,; C. Zhang,; X. Z. Zhang, An O2 self-sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy. Adv. Funct. Mater. 2016, 26, 7847-7860.
Crossref Google Scholar
[16]
S. T. Gao,; P. L. Zheng,; Z. H. Li,; X. C. Feng,; W. X. Yan,; S. Z. Chen,; W. S. Guo,; D. D. Liu,; X. J. Yang,; S. X. Wang, et al. Biomimetic O2-evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor. Biomaterials 2018, 178, 83-94.
Crossref Google Scholar
[17]
Z. W. Chen,; D. Wen,; Z. Gu, Cargo-encapsulated cells for drug delivery. Sci. China Life Sci. 2020, 63, 599-601.
Crossref Google Scholar
[18]
J. E. Cohen,; A. B. Goldstone,; M. J. Paulsen,; Y. Shudo,; A. N. Steele,; B. B. Edwards,; J. B. Patel,; J. W. MacArthur Jr,; M. S. Hopkins,; C. E. Burnett, et al. An innovative biologic system for photon-powered myocardium in the ischemic heart. Sci. Adv. 2017, 3, e1603078.
Crossref Google Scholar
[19]
K. Liu,; R. R. Xing,; Q. L. Zou,; G. H. Ma,; H. Möhwald,; X. H. Yan, Simple peptide-tuned self-assembly of photosensitizers towards anticancer photodynamic therapy. Angew. Chem., Int. Ed. 2016, 55, 3036-3039.
Crossref Google Scholar
[20]
C. G. Qian,; J. C. Yu,; Y. L. Chen,; Q. Y. Hu,; X. Z. Xiao,; W. J. Sun,; C. Wang,; P. J. Feng,; Q. D. Shen,; Z. Gu, Light-activated hypoxia- responsive nanocarriers for enhanced anticancer therapy. Adv. Mater. 2016, 28, 3313-3320.
Crossref Google Scholar
[21]
Y. Y. Liu,; Y. Liu,; W. B. Bu,; C. Cheng,; C. J. Zuo,; Q. F. Xiao,; Y. Sun,; D. L. Ni,; C. Zhang,; J. N. Liu, et al. Hypoxia induced by upconversion-based photodynamic therapy: Towards highly effective synergistic bioreductive therapy in tumors. Angew. Chem., Int. Ed. 2015, 54, 8105-8109.
Crossref Google Scholar
[22]
A. Schulze,; A. L. Harris, How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012, 491, 364-373.
Crossref Google Scholar
[23]
M. F. Huo,; L. Y. Wang,; L. L. Zhang,; C. Y. Wei,; Y. Chen,; J. L. Shi, Photosynthetic tumor oxygenation by photosensitizer-containing cyanobacteria for enhanced photodynamic therapy. Angew. Chem., Int. Ed. 2020, 59, 1906-1913.
Crossref Google Scholar
[24]
T. Maisch,; J. Baier,; B. Franz,; M. Maier,; M. Landthaler,; R. M. Szeimies,; W. Bäumler, The role of singlet oxygen and oxygen concentration in photodynamic inactivation of bacteria. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 7223-7228.
Crossref Google Scholar
[25]
T. A. Dahl,; W. R. Midden,; P. E. Hartman, Pure exogenous singlet oxygen: Nonmutagenicity in bacteria. Mutat. Res. 1988, 201, 127-136.
Crossref Google Scholar
[26]
A. Vioque,; Transformation of cyanobacteria. In Transgenic Microalgae as Green Cell Factories. R. León,; A. Galván,; E. Fernández,, Eds.; Springer: New York, 2007; 12-22.
[27]
K. Paso,; H. Kallevik,; J. Sjöblom, Measurement of wax appearance temperature using near-infrared (NIR) scattering. Energy Fuels 2009, 23, 4988-4994.
Crossref Google Scholar
[28]
M. Y. Peng,; C. Zollfrank,; L. Wondraczek, Origin of broad NIR photoluminescence in bismuthate glass and bi-doped glasses at room temperature. J. Phys. Condens. Matter. 2009, 21, 285106.
Crossref Google Scholar
[29]
G. F. Luo,; W. H. Chen,; S. Hong,; Q. Cheng,; W. X. Qiu,; X. Z. Zhang, A self-transformable pH-driven membrane-anchoring photosensitizer for effective photodynamic therapy to inhibit tumor growth and metastasis. Adv. Funct. Mater. 2017, 27, 1702122.
Crossref Google Scholar
Nano Research
Volume 14 Issue 3,
March 2021
Pages 667-673
DOI: 10.1007/s12274-020-3094-0
Cite this article:
Zhang Y, Liu H, Dai X, et al. Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors. Nano Research, 2021, 14(3): 667-673. https://doi.org/10.1007/s12274-020-3094-0
Topics:
Chemotherapy Drug deliveryInfrared devices OxygenTumors

900

Views

42

Crossref

0

Web of Science

39

Scopus

0

CSCD

Altmetrics
Received: 17 July 2020
Revised: 01 September 2020
Accepted: 03 September 2020
Published: 01 March 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature
Return