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Nano Research 2021, 14(3): 660-666 https://doi.org/10.1007/s12274-020-3093-1
Research Article | Issue | Published: 01 March 2021

Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy

Show Author's Information Lifeng Hang1( ),  Tao Zhang3,†,  Hua Wen1,  Lianbao Liang1,  Wuming Li1,  Xiaofen Ma1,  Guihua Jiang1,2( )
The Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou 518037, China
The Second School of Clinical Medicine, Southern Medical University, Guangzhou 518037, China
University of Science and Technology of China, Hefei 230027, China

† Present address: School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore

Keywords:
metal-organic frameworks, photodynamic therapy, tetrakis (4-carboxyphenyk) porphyrin, acidic environment
Topics:
IrradiationMetalsOrganic frameworks Organic lasersOrganometallicsTumors
Cite this article:
Hang L, Zhang T, Wen H, et al. Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy. Nano Research, 2021, 14(3): 660-666. https://doi.org/10.1007/s12274-020-3093-1
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Abstract Full text Electronic supplementary material About this article

Photodynamic therapy (PDT) is a widely-used technology for cancer therapy, but conventional photosensitizers still face some drawbacks, such as hydrophobicity, inadequate pharmacokinetics, low cell/tissue specificity, and uncontrollable photodynamic performance during the therapeutic process. Herein, we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks (2D Zn-TCPP MOF) that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP. However, the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure. From the in vitro outcomes, the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments. Due to the acidic tumor microenvironment, the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser. This work offers a promising strategy to develop a next-generation photosensitizer.


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Electronic supplementary material
About this article

Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy

Show Author's information Lifeng Hang1( ), Tao Zhang3,†, Hua Wen1, Lianbao Liang1, Wuming Li1, Xiaofen Ma1, Guihua Jiang1,2( )
The Department of Medical Imaging Guangdong Second Provincial General Hospital, Guangzhou 518037, China
The Second School of Clinical Medicine, Southern Medical University, Guangzhou 518037, China
University of Science and Technology of China, Hefei 230027, China

† Present address: School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore

Abstract

Photodynamic therapy (PDT) is a widely-used technology for cancer therapy, but conventional photosensitizers still face some drawbacks, such as hydrophobicity, inadequate pharmacokinetics, low cell/tissue specificity, and uncontrollable photodynamic performance during the therapeutic process. Herein, we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks (2D Zn-TCPP MOF) that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP. However, the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure. From the in vitro outcomes, the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments. Due to the acidic tumor microenvironment, the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser. This work offers a promising strategy to develop a next-generation photosensitizer.

Keywords: metal-organic frameworks, photodynamic therapy, tetrakis (4-carboxyphenyk) porphyrin, acidic environment

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Publication history
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Acknowledgements

Publication history

Received: 17 July 2020
Revised: 22 August 2020
Accepted: 03 September 2020
Published: 01 March 2021
Issue date: March 2021

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature

Acknowledgements

This work is supported by the National Natural Science Foundation of China (NSFC) (Nos. 51903162 and U1903120) and Science foundation of Guangdong Second Provincial General Hospital (No. YN2018-001).

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