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Nano Research 2021, 14(4): 920-933 https://doi.org/10.1007/s12274-020-3067-3
Review Article | Issue | Published: 06 November 2020

Recent advances in engineered nanomaterials for acute kidney injury theranostics

Show Author's Information Lefeng Wang1,2,  Yunjing Zhang3,  Yangyang Li4( ),  Jianghua Chen1,2( ),  Weiqiang Lin3( )
Kidney Disease Center, the First Affiliated Hospital, Zhejiang University School of Medicine; Institute of Nephrology, Zhejiang University, Hangzhou 310003, China
Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou 310003, China
The Fourth Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Jinhua 322000, China
Key Laboratory of Women’s Reproductive Health Research of Zhejiang Province, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
Keywords:
therapy, nanomaterials, acute kidney injury, early detection, translational applications
Topics:
DiagnosisNanostructured materials
Cite this article:
Wang L, Zhang Y, Li Y, et al. Recent advances in engineered nanomaterials for acute kidney injury theranostics. Nano Research, 2021, 14(4): 920-933. https://doi.org/10.1007/s12274-020-3067-3
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Abstract Full text About this article

Acute kidney injury (AKI), has become the focus of increasing attention due to its high risk of death. The early diagnosis and treatment of AKI significantly reduce the risk of renal tissue damage and kidney dysfunction. However, the efficient early diagnosis and treatment approach for AKI remains a challenge. AKI screening via precise nanomaterial theranostics is a new alternative approach. This study summarizes the recent advances in functional nanomaterials in the early detection and treatment of AKI. The challenges and problems in the use of nanomaterials for AKI in clinical applications are also discussed. It is anticipated that highlighting these new advances will lay the foundation for further translational research on the promising application of nanomaterials for AKI.


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About this article

Recent advances in engineered nanomaterials for acute kidney injury theranostics

Show Author's information Lefeng Wang1,2, Yunjing Zhang3, Yangyang Li4( ), Jianghua Chen1,2( ), Weiqiang Lin3( )
Kidney Disease Center, the First Affiliated Hospital, Zhejiang University School of Medicine; Institute of Nephrology, Zhejiang University, Hangzhou 310003, China
Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou 310003, China
The Fourth Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Jinhua 322000, China
Key Laboratory of Women’s Reproductive Health Research of Zhejiang Province, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China

Abstract

Acute kidney injury (AKI), has become the focus of increasing attention due to its high risk of death. The early diagnosis and treatment of AKI significantly reduce the risk of renal tissue damage and kidney dysfunction. However, the efficient early diagnosis and treatment approach for AKI remains a challenge. AKI screening via precise nanomaterial theranostics is a new alternative approach. This study summarizes the recent advances in functional nanomaterials in the early detection and treatment of AKI. The challenges and problems in the use of nanomaterials for AKI in clinical applications are also discussed. It is anticipated that highlighting these new advances will lay the foundation for further translational research on the promising application of nanomaterials for AKI.

Keywords: therapy, nanomaterials, acute kidney injury, early detection, translational applications

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Publication history
Copyright
Acknowledgements

Publication history

Received: 09 July 2020
Revised: 19 August 2020
Accepted: 22 August 2020
Published: 06 November 2020
Issue date: April 2021

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature

Acknowledgements

This work was supported by grants from the National Key R&D Program of China (No. 2018YFC2000400), and the National Natural Science Foundation of China (Nos. 31470776, 81670651, 81770752, and 81970573).

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