Functionalized graphene oxide nanosheets with unique three-in-one properties for efficient and tunable antibacterial applications

Bo-Yao Lu; Guan-Yin Zhu; Chen-Hao Yu; Ge-Yun Chen; Chao-Liang Zhang; Xin Zeng; Qian-Ming Chen; Qiang Peng

doi:10.1007/s12274-020-3064-6

Nano Research 2021, 14(1): 185-190 https://doi.org/10.1007/s12274-020-3064-6

Research Article | Issue | Published: 05 January 2021

Functionalized graphene oxide nanosheets with unique three-in-one properties for efficient and tunable antibacterial applications

Show Author's Information Hide Author's Information Bo-Yao Lu^{^§}, Guan-Yin Zhu^{^§}, Chen-Hao Yu, Ge-Yun Chen, Chao-Liang Zhang, Xin Zeng, Qian-Ming Chen, Qiang Peng(

)

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

^§ Bo-Yao Lu and Guan-Yin Zhu contributed equally to this work.

Keywords:

carbon, nanoparticles, nanomaterials, antimicrobial, nano-bio interaction, dental caries

Topics:

Nano unit Antibiotics Graphene Infrared devices Irradiation Nanosheets

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Lu B-Y, Zhu G-Y, Yu C-H, et al. Functionalized graphene oxide nanosheets with unique three-in-one properties for efficient and tunable antibacterial applications. Nano Research, 2021, 14(1): 185-190. https://doi.org/10.1007/s12274-020-3064-6

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Abstract

Developing antibiotics-independent antibacterial agents is of great importance since antibiotic therapy faces great challenges from drug resistance. Graphene oxide (GO) is a promising agent due to its natural antibacterial mechanisms, such as sharp edge-mediated cutting effect. However, the antibacterial activity of GO is limited by its negative charge and low photothermal effect. Herein, the amino-functionalized GO nanosheets (AGO) with unique three-in-one properties were synthesized. Three essential properties (positive charge, strong photothermal effect, and natural cutting effect) were integrated into AGO. The positive charge (30 mV) rendered AGO a strong interaction force with model pathogen Streptococcus mutans (330 nN). The natural cutting effect of 100 μg·mL^-1 AGO caused 27% loss of bacterial viability after incubation for 30 min. Most importantly, upon the near-infrared irradiation for just 5 min, the three-in-one properties of AGO caused 98% viability loss. In conclusion, the short irradiation period and the tunable antibacterial activity confer the three-in-one AGO a great potential for clinical use.

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About this article

Functionalized graphene oxide nanosheets with unique three-in-one properties for efficient and tunable antibacterial applications

Show Author's information Hide Author's Information Bo-Yao Lu^{^§}, Guan-Yin Zhu^{^§}, Chen-Hao Yu, Ge-Yun Chen, Chao-Liang Zhang, Xin Zeng, Qian-Ming Chen, Qiang Peng(

)

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

^§ Bo-Yao Lu and Guan-Yin Zhu contributed equally to this work.

Abstract

Keywords: carbon, nanoparticles, nanomaterials, antimicrobial, nano-bio interaction, dental caries

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Acknowledgements

Publication history

Received: 05 June 2020

Revised: 20 August 2020

Accepted: 22 August 2020

Published: 05 January 2021

Issue date: January 2021

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81973261 and U19A2005), the Foundation of West China Hospital of Stomatology (No. RD-02-201903), and the Research Funding for Talents Developing, West China Hospital of Stomatology, Sichuan University (No. RCDWJS2020-7).