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Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their capability to address the limitations of traditional enzymes such as fragility, high cost, and impossible mass production. Over the past decade, a broad variety of nanomaterials have been found to mimic the enzyme-like activity by engineering the active centers of natural enzymes or developing multivalent elements within nanostructures. Carbon nanomaterials with well-defined electronic and geometric structures have served as favorable surrogates of traditional enzymes by mimicking the highly evolved catalytic center of natural enzymes. In particular, by combining the unique electronic, optical, thermal, and mechanical properties, carbon nanomaterials-based nanozymes can offer a variety of multifunctional platforms for biomedical applications. In this review, we will introduce the enzymatic characteristics and recent advances of carbon nanozymes, and summarize their significant applications in biomedicine.

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Publication history

Received: 24 June 2020
Revised: 05 August 2020
Accepted: 12 August 2020
Published: 01 March 2021
Issue date: March 2021

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© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature

Acknowledgements

This work was supported by China Postdoctoral Science Foundation (Nos. 2019T120754 and 2018M633229), Sanming Project of Medicine in Shenzhen (No. SZSM201612031), Natural Science Foundation of Guangdong Province of China (Nos. 2018A030310665 and 2018A0303130295), Shenzhen Science and Technology Innovation Committee (Nos. ZDSYS201707281114196, JCYJ20170306091657539, JCYJ20170413162242627, JCYJ20190806163814395, JCYJ20170306091452714, and GJHZ20170313172439851), Development and Reform Commission of Shenzhen Municipality (No. S2016005470013), the National Key R&D Program of China (No. 2017YFA0205501), and the National Natural Science Foundation of China (Nos. 81722024 and 81571728).

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Email: nanores@tup.tsinghua.edu.cn

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