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Nano Research 2020, 13(12): 3377-3386 https://doi.org/10.1007/s12274-020-3025-0
Research Article | Issue | Published: 29 August 2020

Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics

Show Author's Information Zhike Li1,  Xi Qiao1,  Guihua He1,  Xin Sun1,  Danhua Feng1,  Liefeng Hu1,  Hua Xu2,  Hai-Bing Xu3,  Shengqian Ma4( ),  Jian Tian1( )
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China
Department of Chemistry, University of North Texas, Denton, TX 76201, USA
Keywords:
photodynamic therapy, theranostics, nanoscale metal-organic frameworks, core-satellite structures, upconversion nanoparticles (UCNPs)
Topics:
Nano biologyInfrared devices LightMetal nanoparticlesOrganic frameworks OrganometallicsSelf assemblyTheranostics
Cite this article:
Li Z, Qiao X, He G, et al. Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics. Nano Research, 2020, 13(12): 3377-3386. https://doi.org/10.1007/s12274-020-3025-0
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Abstract Full text Electronic supplementary material About this article

The nanoplatforms based on upconversion nanoparticles (UCNPs) have shown great promise in amplified photodynamic therapy (PDT) triggered by near-infrared (NIR) light. However, their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence (UCL) by photosensitizers. To solve these defects, core-satellite metal-organic framework@UCNP superstructures, composed of a single metal-organic framework (MOF) NP as the core and Nd3+-sensitized UCNPs as the satellites, are designed and synthesized via a facile electrostatic self-assembly strategy. The superstructures realize a high co-loading capacity of chlorin e6 (Ce6) and rose bengal (RB) benefitted from the highly porous nature of MOF NPs, showing a strong spectral overlap between maximum absorption of photosensitizers and emission of UCNPs. The in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal (magnetic resonance (MR)/UCL/fluorescence (FL)) imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation, avoiding the laser irradiation-induced overheating issue. This study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics.


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Abstract
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Electronic supplementary material
About this article

Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics

Show Author's information Zhike Li1, Xi Qiao1, Guihua He1, Xin Sun1, Danhua Feng1, Liefeng Hu1, Hua Xu2, Hai-Bing Xu3, Shengqian Ma4( ), Jian Tian1( )
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China
Department of Chemistry, University of North Texas, Denton, TX 76201, USA

Abstract

The nanoplatforms based on upconversion nanoparticles (UCNPs) have shown great promise in amplified photodynamic therapy (PDT) triggered by near-infrared (NIR) light. However, their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence (UCL) by photosensitizers. To solve these defects, core-satellite metal-organic framework@UCNP superstructures, composed of a single metal-organic framework (MOF) NP as the core and Nd3+-sensitized UCNPs as the satellites, are designed and synthesized via a facile electrostatic self-assembly strategy. The superstructures realize a high co-loading capacity of chlorin e6 (Ce6) and rose bengal (RB) benefitted from the highly porous nature of MOF NPs, showing a strong spectral overlap between maximum absorption of photosensitizers and emission of UCNPs. The in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal (magnetic resonance (MR)/UCL/fluorescence (FL)) imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation, avoiding the laser irradiation-induced overheating issue. This study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics.

Keywords: photodynamic therapy, theranostics, nanoscale metal-organic frameworks, core-satellite structures, upconversion nanoparticles (UCNPs)

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Publication history
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Acknowledgements

Publication history

Received: 15 April 2020
Revised: 28 July 2020
Accepted: 01 August 2020
Published: 29 August 2020
Issue date: December 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature

Acknowledgements

This work was financially supported by National Natural Science Foundation of China (NSFC) (Nos. 21601140 and 21871214), the Fundamental Research Funds for the Central Universities, and Open Research Fund of State Key Laboratory of Bioelectronics.

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