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Nano Research 2020, 13(12): 3268-3277 https://doi.org/10.1007/s12274-020-3000-9
Research Article | Issue | Published: 14 August 2020

Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies

Show Author's Information Tao Chen,  Lichao Su,  Xiaoguang Ge,  Wenmin Zhang,  Qingqing Li,  Xuan Zhang,  Jiamin Ye,  Lisen Lin,  Jibin Song( ),  Huanghao Yang( )
MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, China
Keywords:
fluorescence imaging, photoacoustic imaging, radiotherapy, second near-infrared window (NIR-II), plasmonic gold nanovesicle
Topics:
DiseasesDrug deliveryFluorescence imagingGold Nanorods Infrared devices NanorodsPlasmonic nanoparticles Plasmonics Self assemblyTheranostics
Cite this article:
Chen T, Su L, Ge X, et al. Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies. Nano Research, 2020, 13(12): 3268-3277. https://doi.org/10.1007/s12274-020-3000-9
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Abstract Full text Electronic supplementary material About this article

Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.


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About this article

Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies

Show Author's information Tao Chen, Lichao Su, Xiaoguang Ge, Wenmin Zhang, Qingqing Li, Xuan Zhang, Jiamin Ye, Lisen Lin, Jibin Song( ), Huanghao Yang( )
MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, China

Abstract

Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.

Keywords: fluorescence imaging, photoacoustic imaging, radiotherapy, second near-infrared window (NIR-II), plasmonic gold nanovesicle

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Publication history
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Acknowledgements

Publication history

Received: 21 June 2020
Revised: 19 July 2020
Accepted: 20 July 2020
Published: 14 August 2020
Issue date: December 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 21635002 and 21874024), and the joint research projects of Health and Education Commission of Fujian Province (No. 2019-WJ-20).

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