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Nano Research 2020, 13(9): 2427-2430 https://doi.org/10.1007/s12274-020-2869-7
Research Article | Issue | Published: 08 June 2020

Molecular recognition and homochirality preservation of guanine tetrads in the presence of melamine

Show Author's Information Yanghan Chen1,2,§,  Chong Chen2,§,  Pengcheng Ding1,2,  Guoqiang Shi2,  Ye Sun1,  Lev N. Kantorovich3,  Flemming Besenbacher4,  Miao Yu2( )
Condensed Matter Science and Technology Institute, School of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Department of Physics, King’s College London, London WC2R 2LS, UK
Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark

§ Yanghan Chen and Chong Chen contributed equally to this work.

Keywords:
molecular recognition, guanine-tetrad, base pairing, homochirality, biochemical synthesis
Topics:
Biochemistry Hydrogen bonds Positive ionsScanning tunneling microscopy
Cite this article:
Chen Y, Chen C, Ding P, et al. Molecular recognition and homochirality preservation of guanine tetrads in the presence of melamine. Nano Research, 2020, 13(9): 2427-2430. https://doi.org/10.1007/s12274-020-2869-7
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Abstract Full text Electronic supplementary material About this article

Molecular recognition between nucleobases plays a crucial role in all kinds of biological processes. However, real-space investigation of the recognition capability of nucleobases in the presence of interfering compounds remains unexplored. Herein, based on the combination of scanning tunneling microscopy imaging and density functional theory modeling, we report the impact of the presence of melamine (M) on the formation and chirality of guanine (G)-tetrads on Au(111). Although M can interact with G by double hydrogen bonding, the Hoogsteen base pairing of G is not compromised, forming identical individual G-tetrads as would have happened without the presence of M. G-tetrads coexist with M on the surface not only in separate domains, but also within the mixture network of G-tetrads and M-dimers. Although the adsorption orientation of G-tetrads in the mixture network diversifies into two distinct angles, all G-tetrads in the network keep the same chirality, emphasizing the high preference of homochirality in such biochemical systems.


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About this article

Molecular recognition and homochirality preservation of guanine tetrads in the presence of melamine

Show Author's information Yanghan Chen1,2,§, Chong Chen2,§, Pengcheng Ding1,2, Guoqiang Shi2, Ye Sun1, Lev N. Kantorovich3, Flemming Besenbacher4, Miao Yu2( )
Condensed Matter Science and Technology Institute, School of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Department of Physics, King’s College London, London WC2R 2LS, UK
Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark

§ Yanghan Chen and Chong Chen contributed equally to this work.

Abstract

Molecular recognition between nucleobases plays a crucial role in all kinds of biological processes. However, real-space investigation of the recognition capability of nucleobases in the presence of interfering compounds remains unexplored. Herein, based on the combination of scanning tunneling microscopy imaging and density functional theory modeling, we report the impact of the presence of melamine (M) on the formation and chirality of guanine (G)-tetrads on Au(111). Although M can interact with G by double hydrogen bonding, the Hoogsteen base pairing of G is not compromised, forming identical individual G-tetrads as would have happened without the presence of M. G-tetrads coexist with M on the surface not only in separate domains, but also within the mixture network of G-tetrads and M-dimers. Although the adsorption orientation of G-tetrads in the mixture network diversifies into two distinct angles, all G-tetrads in the network keep the same chirality, emphasizing the high preference of homochirality in such biochemical systems.

Keywords: molecular recognition, guanine-tetrad, base pairing, homochirality, biochemical synthesis

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Publication history
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Acknowledgements

Publication history

Received: 30 January 2020
Revised: 04 May 2020
Accepted: 10 May 2020
Published: 08 June 2020
Issue date: September 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 21473045 and 51772066) and State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology (No. 2018DX04).

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