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Nano Research 2020, 13(8): 2268-2279 https://doi.org/10.1007/s12274-020-2846-1
Research Article | Issue | Published: 05 August 2020

Cobalt-based metal-organic framework as a dual cooperative controllable release system for accelerating diabetic wound healing

Show Author's Information Jiankai Li1,§,  Fang Lv2,4,§,  Jinxiu Li1,§,  Yuxin Li2,  Jingduo Gao2,  Jian Luo2,  Feng Xue4( ),  Qinfei Ke1,3( ),  He Xu1( )
College of Chemical and Materials Sciences, Shanghai Normal University, No.100 Guilin Road, Shanghai 200234, China
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Science and School of Life Science, East China Normal University, Shanghai 200241, China
School of Materials Science and Engineering, Shanghai Institute of Technology, No. 120 Caobao Road, Shanghai 200235, China
Southern Medical University Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai 201499, China

§ Jiankai Li, Fang Lv, and Jinxiu Li contributed equally to this work.

Keywords:
drug delivery, angiogenesis, metal-organic framework, cobalt ion, diabetic wound healing
Topics:
Nano biologyCobaltNanofibersNanoparticlesTargeted drug deliveryTissue regeneration
Cite this article:
Li J, Lv F, Li J, et al. Cobalt-based metal-organic framework as a dual cooperative controllable release system for accelerating diabetic wound healing. Nano Research, 2020, 13(8): 2268-2279. https://doi.org/10.1007/s12274-020-2846-1
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Abstract Full text Electronic supplementary material About this article

Insufficient angiogenesis in the chronic wound of the diabetic is one of the most important causes that making the wound unable to heal itself. In this work, a cobalt-based metal-organic framework (ZIF-67) was introduced as a carrier for loading a pro-angiogenic small molecular drug (dimethyloxalylglycine, DMOG). To achieve a long-term angiogenic therapy on the diabetic wound beds, a dual cooperative controllable release system has been designed by incorporating the drug-loaded ZIF-67 nanoparticles into the micro-patterned PLLA/Gelatin nanofibrous scaffolds. The results showed that DMOG was incorporated into ZIF-67 with a high loading ratio (359.12 mg/g), and the drug-loaded ZIF-67 nanoparticles were well embedded in the circular patterned scaffold. Notably, the DMOG as well as Co ions could continuously release from the scaffold for more than 15 days. The in vitro studies showed that the released Co ions and DMOG from the micropatterned nanofibrous scaffolds could synergistically promote the proliferation, migration and tube formation of the human umbilical vein endothelial cells (HUVECs) by inducing a hypoxia response and upregulating the expression of angiogenesis-related genes such as HIF-1α, VEGF and e-NOS. Furthermore, the in vivo results demonstrated that the composite scaffolds could significantly enhance angiogenesis, collagen deposition and eliminate inflammation in the diabetes wounds. These results indicate that the cobalt-based metal-organic framework as a dual cooperative controllable release system provides a new strategy for enhancing angiogenesis and promoting diabetic wound healing.


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Electronic supplementary material
About this article

Cobalt-based metal-organic framework as a dual cooperative controllable release system for accelerating diabetic wound healing

Show Author's information Jiankai Li1,§, Fang Lv2,4,§, Jinxiu Li1,§, Yuxin Li2, Jingduo Gao2, Jian Luo2, Feng Xue4( ), Qinfei Ke1,3( ), He Xu1( )
College of Chemical and Materials Sciences, Shanghai Normal University, No.100 Guilin Road, Shanghai 200234, China
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Science and School of Life Science, East China Normal University, Shanghai 200241, China
School of Materials Science and Engineering, Shanghai Institute of Technology, No. 120 Caobao Road, Shanghai 200235, China
Southern Medical University Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai 201499, China

§ Jiankai Li, Fang Lv, and Jinxiu Li contributed equally to this work.

Abstract

Insufficient angiogenesis in the chronic wound of the diabetic is one of the most important causes that making the wound unable to heal itself. In this work, a cobalt-based metal-organic framework (ZIF-67) was introduced as a carrier for loading a pro-angiogenic small molecular drug (dimethyloxalylglycine, DMOG). To achieve a long-term angiogenic therapy on the diabetic wound beds, a dual cooperative controllable release system has been designed by incorporating the drug-loaded ZIF-67 nanoparticles into the micro-patterned PLLA/Gelatin nanofibrous scaffolds. The results showed that DMOG was incorporated into ZIF-67 with a high loading ratio (359.12 mg/g), and the drug-loaded ZIF-67 nanoparticles were well embedded in the circular patterned scaffold. Notably, the DMOG as well as Co ions could continuously release from the scaffold for more than 15 days. The in vitro studies showed that the released Co ions and DMOG from the micropatterned nanofibrous scaffolds could synergistically promote the proliferation, migration and tube formation of the human umbilical vein endothelial cells (HUVECs) by inducing a hypoxia response and upregulating the expression of angiogenesis-related genes such as HIF-1α, VEGF and e-NOS. Furthermore, the in vivo results demonstrated that the composite scaffolds could significantly enhance angiogenesis, collagen deposition and eliminate inflammation in the diabetes wounds. These results indicate that the cobalt-based metal-organic framework as a dual cooperative controllable release system provides a new strategy for enhancing angiogenesis and promoting diabetic wound healing.

Keywords: drug delivery, angiogenesis, metal-organic framework, cobalt ion, diabetic wound healing

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Acknowledgements

Publication history

Received: 10 January 2020
Revised: 30 April 2020
Accepted: 01 May 2020
Published: 05 August 2020
Issue date: August 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was supported by the Natural Science Foundation of Shanghai (No. 19ZR1437800).

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