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Nano Research 2020, 13(8): 2246-2258 https://doi.org/10.1007/s12274-020-2844-3
Research Article | Issue | Published: 05 August 2020

Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy

Show Author's Information Lifang Yang1,  Chuchu Ren1,  Min Xu1,  Yilin Song1,  Qianglan Lu1,  Yule Wang2,3,  Yan Zhu2,3,  Xinxing Wang4( ),  Nan Li1( )
Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China
Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, 220 Dongting Road, TEDA, Tianjin 300457, China
Tianjin Institute of Environmental and Operational Medicine, 1 Dali Road, Heping District, Tianjin 300050, China
Keywords:
hypoxia, nanozyme, self-supplied, mutual-reinforcing, catalysis-enhanced therapy
Topics:
Biomimetics Catalysis Catalytic oxidation GlucoseGoldGold nanoparticlesManganese oxideNanorodsSilicaTheranostics
Cite this article:
Yang L, Ren C, Xu M, et al. Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy. Nano Research, 2020, 13(8): 2246-2258. https://doi.org/10.1007/s12274-020-2844-3
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Abstract Full text Electronic supplementary material About this article

Biomimetic nanozymes possessing natural enzyme-mimetic activities have been extensively applied in nanocatalytic tumor therapy. However, engineering hybrid biomimetic nanozymes to achieve superior nanozyme activity remained to be an intractable challenge in hypoxic tumors. Herein, a rod-like biomimetic hybrid inorganic MnO2-Au nanozymes are developed, where MnO2 and ultrasmall Au nanoparticles (NPs) are successively deposited on the mesoporous silica nanorod to cooperatively improve the O2 content and thermal sensitivity of hypoxic solid tumors guided by multi-modal imaging. Under the catalyzing of MnO2, the intratumoral H2O2 is decomposed to greatly accelerate O2 generation, which could boost the curative effect of radiation therapy (RT) and further enhance the Au-catalyzed glucose oxidation. Mutually, the Au NPs can steadily and efficiently catalyze the oxidation of glucose in harsh tumor microenvironment, thus sensitizing tumor cells to thermal ablation for mild photothermal therapy and further promoting the catalytic efficiency of MnO2 with the self-supplied H2O2/H+. As a result, this mutual-reinforcing cycle can endow the nanoplatform with accelerated O2 generation, thus alleviating hypoxic environment and further boosting RT effect. Furthermore, acute glucose consuming can induce downregulation expression of heat shock protein (HSP), achieving starvation-promoted mild photothermal therapy. This synthesized hybrid nanozymes proves to be a versatile theranostic agent for nanocatalytic cancer therapy.


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Electronic supplementary material
About this article

Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy

Show Author's information Lifang Yang1, Chuchu Ren1, Min Xu1, Yilin Song1, Qianglan Lu1, Yule Wang2,3, Yan Zhu2,3, Xinxing Wang4( ), Nan Li1( )
Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China
Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, 220 Dongting Road, TEDA, Tianjin 300457, China
Tianjin Institute of Environmental and Operational Medicine, 1 Dali Road, Heping District, Tianjin 300050, China

Abstract

Biomimetic nanozymes possessing natural enzyme-mimetic activities have been extensively applied in nanocatalytic tumor therapy. However, engineering hybrid biomimetic nanozymes to achieve superior nanozyme activity remained to be an intractable challenge in hypoxic tumors. Herein, a rod-like biomimetic hybrid inorganic MnO2-Au nanozymes are developed, where MnO2 and ultrasmall Au nanoparticles (NPs) are successively deposited on the mesoporous silica nanorod to cooperatively improve the O2 content and thermal sensitivity of hypoxic solid tumors guided by multi-modal imaging. Under the catalyzing of MnO2, the intratumoral H2O2 is decomposed to greatly accelerate O2 generation, which could boost the curative effect of radiation therapy (RT) and further enhance the Au-catalyzed glucose oxidation. Mutually, the Au NPs can steadily and efficiently catalyze the oxidation of glucose in harsh tumor microenvironment, thus sensitizing tumor cells to thermal ablation for mild photothermal therapy and further promoting the catalytic efficiency of MnO2 with the self-supplied H2O2/H+. As a result, this mutual-reinforcing cycle can endow the nanoplatform with accelerated O2 generation, thus alleviating hypoxic environment and further boosting RT effect. Furthermore, acute glucose consuming can induce downregulation expression of heat shock protein (HSP), achieving starvation-promoted mild photothermal therapy. This synthesized hybrid nanozymes proves to be a versatile theranostic agent for nanocatalytic cancer therapy.

Keywords: hypoxia, nanozyme, self-supplied, mutual-reinforcing, catalysis-enhanced therapy

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Publication history
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Acknowledgements

Publication history

Received: 09 January 2020
Revised: 30 April 2020
Accepted: 01 May 2020
Published: 05 August 2020
Issue date: August 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was supported by Young Elite Scientists Sponsorship Program by Tianjin (No. 0701320001). And this work was partially supported by the grants of the National Natural Science Foundation of China (Nos. 31971106 and 81372124).

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