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Nano Research 2020, 13(8): 2216-2225 https://doi.org/10.1007/s12274-020-2839-0
Research Article | Issue | Published: 05 August 2020

A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

Show Author's Information Hongwei Lu1,2,  Yongjing Xu2,  Ruirui Qiao3,  Ziwei Lu4,  Pin Wang5,  Xindan Zhang6,  An Chen1,  Liming Zou2( ),  Zhongling Wang1( )
Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville VIC 3052, Australia
Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210029, China
Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China
Keywords:
photothermal therapy, synergetic effect, theranostic agent, clustered SPIO nanoplatform, T2 MRI, micro-tumor detection
Topics:
Carbon nanotubesDiseasesIron oxidesOrganic acids TheranosticsTumors
Cite this article:
Lu H, Xu Y, Qiao R, et al. A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy. Nano Research, 2020, 13(8): 2216-2225. https://doi.org/10.1007/s12274-020-2839-0
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Abstract Full text Electronic supplementary material About this article

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we reported a novel super-paramagnetic iron oxide (SPIO) based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose. This polyethylene glycol with four phenylboronic acid (PEG-B4)/CNTs@porphyrin (ph)/SPIO (BCPS) nanoplatform was simply prepared via integrated SPIO, ph, and a novel dendrimer with PEG liner and four PBA groups (PEG-B4) on the surface of carbon nanotubes (CNTs). Subsequently, a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering. Moreover, the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy. Furthermore, the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4. We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor (1 mm) in the liver, but also effectively ablate tumors in a xenograft model, thereby achieving a complete cure rate of 100% at low laser dose. Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.


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Electronic supplementary material
About this article

A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

Show Author's information Hongwei Lu1,2, Yongjing Xu2, Ruirui Qiao3, Ziwei Lu4, Pin Wang5, Xindan Zhang6, An Chen1, Liming Zou2( ), Zhongling Wang1( )
Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville VIC 3052, Australia
Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210029, China
Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China

Abstract

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we reported a novel super-paramagnetic iron oxide (SPIO) based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose. This polyethylene glycol with four phenylboronic acid (PEG-B4)/CNTs@porphyrin (ph)/SPIO (BCPS) nanoplatform was simply prepared via integrated SPIO, ph, and a novel dendrimer with PEG liner and four PBA groups (PEG-B4) on the surface of carbon nanotubes (CNTs). Subsequently, a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering. Moreover, the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy. Furthermore, the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4. We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor (1 mm) in the liver, but also effectively ablate tumors in a xenograft model, thereby achieving a complete cure rate of 100% at low laser dose. Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

Keywords: photothermal therapy, synergetic effect, theranostic agent, clustered SPIO nanoplatform, T2 MRI, micro-tumor detection

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Publication history
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Acknowledgements

Publication history

Received: 02 February 2020
Revised: 27 April 2020
Accepted: 29 April 2020
Published: 05 August 2020
Issue date: August 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

The authors would like to acknowledge the Research Center for Analysis & Measurement of Donghua University. This work was supported by National Natural Science Foundation of China (No. 81971664), Shanghai Pujang Program (No. 2019PJD044), National Key Research and Development Project of China (No. 2016YFB0303200) and Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support.

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