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Electrodynamic therapy (EDT) is a conceptually new cancer treatment approach recently proposed by our group. During EDT, the electro-driven catalytic reaction would occur on the surface of platinum nanoparticles (PtNPs) to produce reactive oxygen species (ROS) under the direct current (DC) or square-wave alternating current (AC) electric field. To further extend the potential of EDT, we hereby designed mesoporous silica-based nanocomposites decorated with PtNPs and loaded with anticancer drug doxorubicin (DOX) for synergistic electrodynamic-chemotherapy. Such silica-based nanocomposites could enable homogenous killing of large-sized tumors (over 500 mm3) and realize remarkable tumor destruction efficacy at a relatively low quantity of electricity. To our best knowledge, this is the first study to combine EDT and chemotherapy to develop a synergetic nanoplatform, openning a new dimension for the design of other EDT-based anticancer strategies.
This work was financially supported by National Nature Science Foundation of China (No. 51672247), '111’ Program funded by Education Ministry of China and Sate Bureau of Foreign Experts Affairs (No. B16043), the Collaborative Innovation Center of Suzhou Nano Science and Technology, Fundamental Research Funds for the Central Universities, Major State Research Program of China (No. 2016YFC1101900), ZJU-Hangzhou Global Scientific and Technological Innovation Center and Provincial Key Research Program of Zhejiang Province (No. 2020C04005).