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Nano Research 2020, 13(8): 2118-2129 https://doi.org/10.1007/s12274-020-2818-5
Research Article | Issue | Published: 05 August 2020

NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au-Ag nanozyme

Show Author's Information Min Xu1,  Qianglan Lu1,  Yiling Song1,  Lifang Yang1,  Chuchu Ren1,  Wen Li1,  Ping Liu1,  Yule Wang2,3,  Yan Zhu2,3,  Nan Li1( )
Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China
Keywords:
near-infrared (NIR)-II driven, plasmon-enhanced catalysis, Au-Ag hollow nanotriangles, bio-breakable, cascade reaction
Topics:
Biomimetics Catalysis Glucose oxidaseGlucose sensors Infrared devices NanostructuresPlasmonsSurface plasmon resonanceTumors
Cite this article:
Xu M, Lu Q, Song Y, et al. NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au-Ag nanozyme. Nano Research, 2020, 13(8): 2118-2129. https://doi.org/10.1007/s12274-020-2818-5
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Abstract Full text Electronic supplementary material About this article

Emerging nanozymes with natural enzyme-mimicking catalytic activities have inspired extensive research interests due to their high stability, low cost, and simple preparation, especially in the field of catalytic tumor therapy. Here, bio-breakable nanozymes based on glucose-oxidase (GOx)-loaded biomimetic Au-Ag hollow nanotriangles (Au-Ag-GOx HTNs) are designed, and they trigger an near-infrared (NIR)-II-driven plasmon-enhanced cascade catalytic reaction through regulating tumor microenvironment (TME) for highly efficient tumor therapy. Firstly, GOx can effectively trigger the generation of gluconic acid (H+) and hydrogen peroxide (H2O2), thus depleting nutrients in the tumor cells as well as modifying TME to provide conditions for subsequent peroxidase (POD)-like activity. Secondly, NIR-II induced surface plasmon resonance can induce hot electrons to enhance the catalytic activity of Au-Ag-GOx HTNs, eventually boosting the generation of hydroxyl radicals (•OH). Interestingly, the generated H2O2 and H+ can simultaneously induce the degradation of Ag nanoprisms to break the intact triangle nanostructure, thus promoting the excretion of Au-Ag-GOx HTNs to avoid the potential risks of drug metabolism. Overall, the NIR-II driven plasmon-enhanced catalytic mechanism of this bio-breakable nanozyme provides a promising approach for the development of nanozymes in tumor therapy.


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Electronic supplementary material
About this article

NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au-Ag nanozyme

Show Author's information Min Xu1, Qianglan Lu1, Yiling Song1, Lifang Yang1, Chuchu Ren1, Wen Li1, Ping Liu1, Yule Wang2,3, Yan Zhu2,3, Nan Li1( )
Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China

Abstract

Emerging nanozymes with natural enzyme-mimicking catalytic activities have inspired extensive research interests due to their high stability, low cost, and simple preparation, especially in the field of catalytic tumor therapy. Here, bio-breakable nanozymes based on glucose-oxidase (GOx)-loaded biomimetic Au-Ag hollow nanotriangles (Au-Ag-GOx HTNs) are designed, and they trigger an near-infrared (NIR)-II-driven plasmon-enhanced cascade catalytic reaction through regulating tumor microenvironment (TME) for highly efficient tumor therapy. Firstly, GOx can effectively trigger the generation of gluconic acid (H+) and hydrogen peroxide (H2O2), thus depleting nutrients in the tumor cells as well as modifying TME to provide conditions for subsequent peroxidase (POD)-like activity. Secondly, NIR-II induced surface plasmon resonance can induce hot electrons to enhance the catalytic activity of Au-Ag-GOx HTNs, eventually boosting the generation of hydroxyl radicals (•OH). Interestingly, the generated H2O2 and H+ can simultaneously induce the degradation of Ag nanoprisms to break the intact triangle nanostructure, thus promoting the excretion of Au-Ag-GOx HTNs to avoid the potential risks of drug metabolism. Overall, the NIR-II driven plasmon-enhanced catalytic mechanism of this bio-breakable nanozyme provides a promising approach for the development of nanozymes in tumor therapy.

Keywords: near-infrared (NIR)-II driven, plasmon-enhanced catalysis, Au-Ag hollow nanotriangles, bio-breakable, cascade reaction

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Publication history
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Acknowledgements

Publication history

Received: 21 February 2020
Revised: 08 April 2020
Accepted: 17 April 2020
Published: 05 August 2020
Issue date: August 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was supported by the Young Elite Scientists Sponsorship Program by Tianjin (No. 0701320001) and major special project of Tianjin (No. 0402080005).

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