Journal Home > Volume 13 , Issue 8

Emerging nanozymes with natural enzyme-mimicking catalytic activities have inspired extensive research interests due to their high stability, low cost, and simple preparation, especially in the field of catalytic tumor therapy. Here, bio-breakable nanozymes based on glucose-oxidase (GOx)-loaded biomimetic Au-Ag hollow nanotriangles (Au-Ag-GOx HTNs) are designed, and they trigger an near-infrared (NIR)-II-driven plasmon-enhanced cascade catalytic reaction through regulating tumor microenvironment (TME) for highly efficient tumor therapy. Firstly, GOx can effectively trigger the generation of gluconic acid (H+) and hydrogen peroxide (H2O2), thus depleting nutrients in the tumor cells as well as modifying TME to provide conditions for subsequent peroxidase (POD)-like activity. Secondly, NIR-II induced surface plasmon resonance can induce hot electrons to enhance the catalytic activity of Au-Ag-GOx HTNs, eventually boosting the generation of hydroxyl radicals (•OH). Interestingly, the generated H2O2 and H+ can simultaneously induce the degradation of Ag nanoprisms to break the intact triangle nanostructure, thus promoting the excretion of Au-Ag-GOx HTNs to avoid the potential risks of drug metabolism. Overall, the NIR-II driven plasmon-enhanced catalytic mechanism of this bio-breakable nanozyme provides a promising approach for the development of nanozymes in tumor therapy.

File
12274_2020_2818_MOESM1_ESM.pdf (3.4 MB)
Publication history
Copyright
Acknowledgements

Publication history

Received: 21 February 2020
Revised: 08 April 2020
Accepted: 17 April 2020
Published: 05 August 2020
Issue date: August 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was supported by the Young Elite Scientists Sponsorship Program by Tianjin (No. 0701320001) and major special project of Tianjin (No. 0402080005).

Return