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Nano Research 2020, 13(6): 1739-1748 https://doi.org/10.1007/s12274-020-2800-2
Research Article | Issue | Published: 19 May 2020

Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer

Show Author's Information Yanpeng Jia1,§,  Yang Song3,§,  Ying Qu1,  Jinrong Peng1,  Kun Shi1,  Dan Du3,  He Li2( ),  Yuehe Lin3( ),  Zhiyong Qian1( )
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan Universityand Collaborative Innovation Center, Chengdu 610041, China
College of Optoelectronics Technology, Chengdu University of Information Technology, Chengdu 610225, China
School of Mechanical and Material Engineering, Washington State University, Pullman, WA 99163, USA

§ Yanpeng Jia and Yang Song contributed equally to this work.

Keywords:
porous structure, inorganic nanoparticles, photoacoustic imaging, photothermal therapy, chemotherapy
Topics:
Binary alloysChemotherapy Medical imagingNanoparticlesOrganic acids Palladium alloysPlatinum alloysSynthesis (chemical)Tumors
Cite this article:
Jia Y, Song Y, Qu Y, et al. Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer. Nano Research, 2020, 13(6): 1739-1748. https://doi.org/10.1007/s12274-020-2800-2
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Abstract Full text Electronic supplementary material About this article

The synergistic therapy of chemotherapy and photothermal therapy (PTT) has been reported as a promising antitumor strategy. To achieve effective combination therapy, developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary. Herein, a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin (DOX) loading. We further designed PtPd-ethylene glycol (PEG)-folic acid (FA)-doxorubicin (DOX) nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting. Moreover, excellent photoacoustic (PA) imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’ targeting effect. The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.


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About this article

Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer

Show Author's information Yanpeng Jia1,§, Yang Song3,§, Ying Qu1, Jinrong Peng1, Kun Shi1, Dan Du3, He Li2( ), Yuehe Lin3( ), Zhiyong Qian1( )
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan Universityand Collaborative Innovation Center, Chengdu 610041, China
College of Optoelectronics Technology, Chengdu University of Information Technology, Chengdu 610225, China
School of Mechanical and Material Engineering, Washington State University, Pullman, WA 99163, USA

§ Yanpeng Jia and Yang Song contributed equally to this work.

Abstract

The synergistic therapy of chemotherapy and photothermal therapy (PTT) has been reported as a promising antitumor strategy. To achieve effective combination therapy, developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary. Herein, a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin (DOX) loading. We further designed PtPd-ethylene glycol (PEG)-folic acid (FA)-doxorubicin (DOX) nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting. Moreover, excellent photoacoustic (PA) imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’ targeting effect. The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.

Keywords: porous structure, inorganic nanoparticles, photoacoustic imaging, photothermal therapy, chemotherapy

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Publication history
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Acknowledgements

Publication history

Received: 12 February 2020
Revised: 06 April 2020
Accepted: 11 April 2020
Published: 19 May 2020
Issue date: June 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

The authors greatly appreciate the help of Dr. Shanling Wang from Analytical & Testing Center in Sichuan University for TEM analysis of our nanoparticles. This work was financially supported by the National Natural Science Foundation of China (Nos. 31930067, 31525009, 31800797, and 31771096), the National Key Research and Development Program of China (Nos. 2017YFC1103502 and 2016YFA0201402), the China Postdoctoral Science Foundation funded project (No. 2018M631094), the Postdoctoral Innovation Talents Support Program (No. BX20180207), and 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University (No. ZYGD18002).

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