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Research Article

Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration

Chun Xu1,2,3, Lan Xiao4, Yuxue Cao1, Yan He1,5,6, Chang Lei7, Yin Xiao4, Wujin Sun2,3, Samad Ahadian2,3, Xueting Zhou8, Ali Khademhosseini2,3,9,10,11( ), Qingsong Ye5,6,†( )
School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia
Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, 4006, Australia
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325035, China
Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Department of Radiological Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90095, USA

† Present address: Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China

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Abstract

Biomaterials with suitable osteoimmunomodulation properties and ability to deliver osteoinductive biomolecules, such as bone morphogenetic proteins, are desired for bone regeneration. Herein, we report the development of mesoporous silica rods with large cone-shaped pores (MSR-CP) to load and deliver large protein drugs. It is noted that those cone-shaped pores on the surface modulated the immune response and reduced the pro-inflammatory reaction of stimulated macrophage. Furthermore, bone morphogenetic proteins 2 (BMP-2) loaded MSR-CP facilitated osteogenic differentiation and promoted osteogenesis of bone marrow stromal cells. In vivo tests confirmed BMP-2 loaded MSR-CP improved the bone regeneration performance. This study provides a potential strategy for the design of drug delivery systems for bone regeneration.

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Keywords

mesoporous silica rodbone regenerationcone shaped poresmorphogenetic proteins 2 (BMP-2) deliveryosteoimmunomodulation

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Nano Research
Volume 13 Issue 9,
September 2020
Pages 2323-2331
DOI: 10.1007/s12274-020-2783-z

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Cite this article:
Xu C, Xiao L, Cao Y, et al. Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration. Nano Research, 2020, 13(9): 2323-2331. https://doi.org/10.1007/s12274-020-2783-z
Topics:
Controlled drug deliverySilicaTargeted drug delivery

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Received: 22 January 2020
Revised: 28 March 2020
Accepted: 30 March 2020
Published: 23 April 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020