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Research Article

One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

Mingyue Cui1,2Christian Wiraja2Lim Wei Qi4Sharon Chew Wan Ting2Deblin Jana4Mengjia Zheng2Xiao Hu1,3Chenjie Xu1,2,5,6( )
Nanyang Environment & Water Research Institute, Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore 637141, Singapore
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
National Dental Centre of Singapore, 5 Second Hospital Ave, Singapore 168938, Singapore
Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China
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Abstract

Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphology and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functionalities. Multiple molecules including fluorophore, folic acid, and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

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Nano Research
Pages 1592-1596

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Cite this article:
Cui M, Wiraja C, Wei Qi L, et al. One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles. Nano Research, 2020, 13(6): 1592-1596. https://doi.org/10.1007/s12274-020-2775-z
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Received: 27 October 2019
Revised: 21 March 2020
Accepted: 24 March 2020
Published: 02 May 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020