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Research Article

In situ assembly of magnetic nanocrystals/graphene oxide nanosheets on tumor cells enables efficient cancer therapy

Mingyang Liu1,2, Yang Lu3, Qilin Yu1,2( ), Shu-Hong Yu2 ( )
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China
Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Nanoscience, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China
Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China
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Abstract

Owing to the stimulus-responsive and dynamic properties, magnetism-driven assembly of building blocks to form ordered structures is always a marvelous topic. While abundant magnetic assemblies have been developed in ideal physical and chemical conditions, it remains a challenge to realize magnetic assembly in complicated biological systems. Herein, we report a kind of biomacromolecule-modified magnetic nanosheets, which are mainly composed of superparamagnetic graphene oxide (γ-Fe2O3@GO), the tumor-targeting protein transferrin (TF), and the mitochondrion-targeting peptide (MitP). Such large-size nanosheets (0.5-1 μm), noted as L-Fe2O3@GO-MitP-TF, can successfully in situ assemble on the surface of tumor cells in a size-dependent and tumor cell-specific way, leading to severe inhibition of nutrient uptake for the tumor cells. More significantly, the nanostructures could efficiently confine the tumor cells, preventing both invasion and metastasis of tumor cells both in vitro and in vivo. Moreover, the 2D assemblies could remarkably disrupt the mitochondria and induce apoptosis, remarkably eradicating tumors under near-infrared (NIR) irradiation. This study sheds light on the development of new nano-systems for efficient cancer therapy and other biomedical applications.

Keywords

magnetic assemblygraphene oxidetransferrinmitochondrion-targeting peptidemetastasiscancer therapy

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Nano Research
Volume 13 Issue 4,
April 2020
Pages 1133-1140
DOI: 10.1007/s12274-020-2759-z
Cite this article:
Liu M, Lu Y, Yu Q, et al. In situ assembly of magnetic nanocrystals/graphene oxide nanosheets on tumor cells enables efficient cancer therapy. Nano Research, 2020, 13(4): 1133-1140. https://doi.org/10.1007/s12274-020-2759-z
Topics:
Cell death DiseasesGrapheneInfrared devices Magnetism Medical applicationsNanosheetsNutrientsOncology

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Received: 20 February 2020
Revised: 15 March 2020
Accepted: 16 March 2020
Published: 14 April 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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