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Research Article

Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy

Jialing Hu, Fuan Wang, Feng Liu, Wentong Sun, Qunying Jiang, Yahua Liu, Yun Zhao, Xiaoqing Liu( )
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
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Abstract

Metastasis remains the primary cause for mortality of breast cancer. Despite advances in current therapeutic agents, patients with metastatic breast cancer still have poor prognoses. Tumor hypoxia, a key microenvironment factor, is emerging as an attractive target to prevent metastasis and is also involved with resistance to phototherapy. Here, we show an effective nanotherapeutic approach based on manganese dioxide-coated polydopamine nanocarriers to trigger robust anti-tumor and anti-metastasis responses against metastatic breast cancer by supplemental oxygenation and multimodal imaging-guided phototherapies. In cancer cells, the produced oxygen by the developed nanoplatform decreases the expression of hypoxia-inducible factors 1α to inhibit tumor metastasis, and enhances the efficacy of photodynamic therapy. This nanotherapeutic approach enables the combined photodynamic/ photothermal treatments with great inhibition on cell migration and invasion in vitro. Moreover, the nanotherapeutics effectively suppresses primary tumor progress and inhibits lung metastasis in vivo in a breast cancer mouse model with satisfying biosafety. This study suggests that the tumor hypoxia-targeting nanotherapeutics have great potential for preventing and treating metastatic cancers.

Keywords

nanomedicinehypoxiabreast cancer metastasissupplemental oxygenationphototherapy

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Nano Research
Volume 13 Issue 4,
April 2020
Pages 1111-1121
DOI: 10.1007/s12274-020-2753-5
Cite this article:
Hu J, Wang F, Liu F, et al. Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy. Nano Research, 2020, 13(4): 1111-1121. https://doi.org/10.1007/s12274-020-2753-5
Topics:
DiagnosisDiseasesManganese oxidePathologyTumors

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Received: 24 December 2019
Revised: 08 March 2020
Accepted: 09 March 2020
Published: 30 March 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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