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Nano Research 2020, 13(4): 1013-1019 https://doi.org/10.1007/s12274-020-2736-6
Research Article | Issue | Published: 11 April 2020

Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy

Show Author's Information Bo Yang1,  Shan Zhou1,  Jie Zeng1,  Liping Zhang1,  Runhao Zhang1,  Kang Liang2,  Lei Xie1,  Bing Shao3,  Shaoli Song4,  Gang Huang5,6,  Dongyuan Zhao1,  Pu Chen7,  Biao Kong1( )
Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai 200032, China
School of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South Wales, NSW 2052, Australia
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China
Department of Nuclear Medicine, Shanghai Cancer Center, Fudan University, Shanghai 200032, China
Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
Institute of Clinical Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
Keywords:
pH-responsive, photothermal therapy, synergistic therapy, metal-polyphenol complex
Topics:
BiocompatibilityCardiovascular system Chemotherapy DiseasesInfrared devices Metal nanoparticlesSilicaSilica nanoparticlesTumors
Cite this article:
Yang B, Zhou S, Zeng J, et al. Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy. Nano Research, 2020, 13(4): 1013-1019. https://doi.org/10.1007/s12274-020-2736-6
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Abstract Full text Electronic supplementary material About this article

Multimodal combinatorial therapy merges different modes of therapies in one platform, which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency. Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy. By super-assembly of mesoporous silica nanoparticles (MSN) with metal-phenolic networks (MPN), anti-cancer drugs can be loaded in the MSN matrix, while the outer MPN coating allows dual photothermal and pH-responsive properties. Upon near-infrared light irradiation, the MSN@MPN nanoplatform exhibits excellent photothermal effect, and demonstrates outstanding pH-triggered drug release property. In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs. Consequently, the MSN@MPN system shows promising prospects in clinical application for tumor therapy.


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Electronic supplementary material
About this article

Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy

Show Author's information Bo Yang1, Shan Zhou1, Jie Zeng1, Liping Zhang1, Runhao Zhang1, Kang Liang2, Lei Xie1, Bing Shao3, Shaoli Song4, Gang Huang5,6, Dongyuan Zhao1, Pu Chen7, Biao Kong1( )
Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai 200032, China
School of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South Wales, NSW 2052, Australia
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China
Department of Nuclear Medicine, Shanghai Cancer Center, Fudan University, Shanghai 200032, China
Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
Institute of Clinical Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada

Abstract

Multimodal combinatorial therapy merges different modes of therapies in one platform, which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency. Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy. By super-assembly of mesoporous silica nanoparticles (MSN) with metal-phenolic networks (MPN), anti-cancer drugs can be loaded in the MSN matrix, while the outer MPN coating allows dual photothermal and pH-responsive properties. Upon near-infrared light irradiation, the MSN@MPN nanoplatform exhibits excellent photothermal effect, and demonstrates outstanding pH-triggered drug release property. In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs. Consequently, the MSN@MPN system shows promising prospects in clinical application for tumor therapy.

Keywords: pH-responsive, photothermal therapy, synergistic therapy, metal-polyphenol complex

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Publication history
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Acknowledgements

Publication history

Received: 10 November 2019
Revised: 23 February 2020
Accepted: 25 February 2020
Published: 11 April 2020
Issue date: April 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was supported by the National Key Research and Development Program of China (Nos. 2019YFC1604600, 2017YFA0206901, 2017YFA0206900), the National Natural Science Foundation of China (Nos. 21705027, 21974029, and 81830052), the Construction project of Shanghai Key Laboratory of Molecular Imaging (No. 18DZ2260400), the Shanghai Municipal Education Commission (Class II Plateau Disciplinary Construction Program of Medical Technology of SUMHS, 2018-2020), the Australia National Health and Medical Research Council (NHMRC) (No. APP1163786), the Scientia Fellowship program at UNSW, the MCTL Visiting Fellowship Program, Shanghai Key Laboratory of Molecular Imaging (No. 18DZ2260400), the Natural Science Foundation of Shanghai, and the Recruitment Program of Global Experts of China and Shanghai.

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